口腔鳞状细胞癌肿瘤相关成纤维细胞的研究进展

doi:10.13701/j.cnki.kqyxyj.2020.04.001

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (4): 309-313.DOI: 10.13701/j.cnki.kqyxyj.2020.04.001

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口腔鳞状细胞癌肿瘤相关成纤维细胞的研究进展

胡勤刚^*, 赵星星

南京大学医学院附属口腔医院口腔颌面外科江苏南京 210008

收稿日期:2020-04-15 出版日期:2020-05-28 发布日期:2020-05-28
通讯作者: 胡勤刚,E-mail:qghu@nju.edu.cn
作者简介:胡勤刚,主任医师,教授,专业技术二级,南京大学博士生导师,南京大学医学院附属口腔医院暨南京市口腔医院名誉院长,国家临床重点专科口腔颌面外科学科带头人。现任中华口腔医学会常务理事,江苏省医学会常务理事,江苏省整形美容协会会长,江苏省口腔质控中心主任,享受国务院特殊津贴。从事口腔颌面部肿瘤、颌面畸形缺损及创伤等疾病的诊疗和研究工作。发表论文130余篇、其中SCI收录论文70余篇,主编专著5部、参编专著3部。先后获国家科技发明四等奖1项、卫生部科技进步三等奖1项、江苏省科学技术二等奖3项,江苏省教学成果(高等教育类)二等奖1项以及发明专利3项。获全国卫生计生系统先进工作者等荣誉称号。现为《口腔医学研究》副主编,《中华口腔医学杂志》、《华西口腔医学杂志》、《实用口腔医学杂志》、《上海口腔医学杂志》、《口腔颌面外科杂志》、《中国口腔颌面外科杂志》编委。

Advancement of Cancer-associated Fibroblasts in Oral Squamous Cell Carcinoma

HU Qingang^*, ZHAO Xingxing

Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University. Nanjing 210008, China

Received:2020-04-15 Online:2020-05-28 Published:2020-05-28

摘要/Abstract

摘要： 口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)是头颈部最常见的恶性肿瘤,与其他恶性肿瘤相似,其肿瘤相关成纤维细胞(cancer-associated fibroblasts,CAFs)是肿瘤微环境中最重要的间质细胞,在肿瘤的增殖、转移、免疫耐受及治疗抵抗等方面发挥重要的调控作用。本文就OSCC中CAFs研究进展及其对临床治疗的启发,建立CAFs作为干预靶点,打破肿瘤细胞赖以生存的微环境,干扰肿瘤细胞的生长和侵袭,有效阻断肿瘤新生血管的形成,激活机体免疫功能,为OSCC辅助治疗提供新的思路和策略。

关键词: 口腔鳞状细胞癌, 肿瘤相关成纤维细胞, 靶向治疗

Abstract: Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck, and cancer-associated fibroblasts (CAFs) are the most important stromal cells in the tumor microenvironment as similar with other malignancies. CAFs were critically involved in the proliferation, metastasis, immune tolerance, and treatment resistance of tumor cells. This paper aims to summarize the recent progress of CAFs in OSCC and its enlightenment for clinical treatment. Targeting CAFs for therapeutic intervention and breaking the essential microenvironment barrier to suppress the growth and migration of tumor cells, effectively block angiogenesis,and enhance immune responses may provide a novel insight and strategies for the adjuvant therapy of OSCC.

Key words: oral squamous cell carcinoma, cancer-associated fibroblasts, targeted therapy

胡勤刚, 赵星星. 口腔鳞状细胞癌肿瘤相关成纤维细胞的研究进展[J]. 口腔医学研究, 2020, 36(4): 309-313.

HU Qingang, ZHAO Xingxing. Advancement of Cancer-associated Fibroblasts in Oral Squamous Cell Carcinoma[J]. Journal of Oral Science Research, 2020, 36(4): 309-313.

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口腔鳞状细胞癌肿瘤相关成纤维细胞的研究进展

Advancement of Cancer-associated Fibroblasts in Oral Squamous Cell Carcinoma

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