口腔医学研究

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (5): 439-442.DOI: 10.13701/j.cnki.kqyxyj.2019.05.007

• 口腔肿瘤学研究 • 上一篇    下一篇

SOX-9在口腔鳞状细胞癌组织中的表达及其临床意义

刘艳玲1, 赵曦1, 余丽2, 聂敏海2*   

  1. 1. 四川省德阳市人民医院口腔科 四川 德阳 618000;
    2. 西南医科大学附属口腔医院 四川 泸州 646000
  • 收稿日期:2018-08-18 出版日期:2019-05-28 发布日期:2019-05-21
  • 通讯作者: 聂敏海,E-mail:nieminhai@126.com
  • 作者简介:刘艳玲(1983~ ),女,硕士,主要从事口腔黏膜病的病因及防治研究。

Expression and Clinical Significance of SOX-9 in Human Oral Squamous Cell Carcinoma.

LIU Yan-ling1, ZHAO Xi1, YU Li2, NIE Min-hai2*   

  1. 1. Department of Stomatology, Deyang People's Hospital, Deyang 618000, China;
    2. Stomatology Hospital, Southwest Medical University, Luzhou 646000, China.;
  • Received:2018-08-18 Online:2019-05-28 Published:2019-05-21

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摘要： 目的: 探讨SOX-9在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)中的表达及其临床意义。方法: 采用免疫组化检测正常口腔黏膜、口腔上皮不典型增生及口腔鳞癌组织中SOX-9蛋白的表达情况,分析SOX-9蛋白与临床病理因素的相关性。结果: SOX-9在正常口腔黏膜组织、口腔上皮不典型增生及口腔鳞癌组织中的阳性表达率分别为10%(2/20)、32.1%(9/28)及79.4%(27/34),SOX-9在3种组织依次增加,在肿瘤发生发展过程中,SOX-9表达增加,各组表达差异有统计意义(P<0.001)。SOX-9表达和患者肿瘤体积、淋巴结转移、临床分期有关。单因素分析显示,肿瘤体积、淋巴结转移、临床分期、SOX-9阳性表达与存活时间有关(P<0.05); Cox多因素分析显示淋巴结转移、临床分期、SOX-9阳性表达是OSCC患者存活时间的独立因素(P<0.05)。结论: SOX-9在口腔鳞癌中异常高表达,SOX-9 表达与口腔鳞癌患者存活率相关。

关键词: SOX-9, 口腔鳞状细胞癌, 口腔黏膜上皮不典型增生

Abstract: Objective: To investigate the expression and clinical significance of SOX-9 in oral squamous cell carcinoma (OSCC). Methods: The expression of SOX-9 protein in normal oral mucosa, atypical hyperplasia of oral epithelium, and oral squamous cell carcinoma was detected by immunohistochemistry, and the correlation between SOX-9 protein and clinicopathological factors was analyzed. Results: The positive expression rates of SOX-9 in normal oral mucosa, atypical epithelial hyperplasia, and oral squamous cell carcinoma were 10% (2/20), 32.1% (9/28), and 79.4% (27/34), respectively. SOX-9 increased in three tissues in turn. The expression of SOX-9 increased in the process of tumor development, and the difference of expression in each group was statistically significant (P<0.001). The expression of SOX-9 was related to tumor volume, lymph node metastasis, and tumor stage. Single factor analysis showed that tumor volume, lymph node metastasis , tumor staging, and SOX-9 positive expression were related to survival time (P<0.05). After Cox multivariate analysis, only lymph node metastasis, tumor stage, and SOX-9 positive expression were independent factors affecting survival time (P<0.05). Conclusions: SOX-9 is highly expressed in oral squamous cell carcinoma. SOX-9 expression is associated with survival rate in patients with oral squamous cell carcinoma.

Key words: SOX-9, Oral squamous cell carcinoma, Atypical hyperplasia of oral mucosa