程序性坏死在颞下颌关节骨关节炎软骨退变中的研究进展

doi:10.13701/j.cnki.kqyxyj.2021.01.004

口腔医学研究 ›› 2021, Vol. 37 ›› Issue (1): 15-18.DOI: 10.13701/j.cnki.kqyxyj.2021.01.004

程序性坏死在颞下颌关节骨关节炎软骨退变中的研究进展

何峰, 于世宾^*

军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔疾病国际联合研究中心,第四军医大学口腔医院口腔解剖生理学教研室陕西西安 710032

收稿日期:2020-01-22 出版日期:2021-01-28 发布日期:2021-01-22
通讯作者: *于世宾,E-mail: yushibin@fmmu.edu.cn
作者简介:何峰(1991~ ),男,安徽安庆人,硕士在读,研究方向:口腔基础医学。
基金资助:
国家自然科学基金(编号:81970953); 陕西省重点研发计划一般项目(编号:2019SF-102)

Research Progress of Necroptosis on Cartilage Degeneration in TMJOA

HE Feng, YU Shibin^*

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Department of Oral Anatomy and Physiology and TMD, School of Stomatology, the Fourth Military Medical University, Xi'an 710032, China

Received:2020-01-22 Online:2021-01-28 Published:2021-01-22

摘要/Abstract

摘要： 颞下颌关节骨关节炎(temporomandibular joint osteoarthritis, TMJOA)是颞下颌关节紊乱病(temporomandibular diseases, TMD)的重症形式。关节软骨退变是TMJOA早期最典型的病理学特征之一,软骨细胞死亡是软骨退变中的核心事件。相比较于凋亡和自噬,新型细胞死亡模式——程序性坏死(necroptosis)发生后所释放的损伤相关分子模式(damage associated molecular patterns, DAMPs)能够对周围细胞、软骨基质造成进一步损害,并且可能形成肿瘤坏死因子-α(tumor necrosis factor α, TNF-α)-necroptosis-DAMPs-TNF-α恶性环路,对软骨造成更大的破坏。因此,本文试对Necroptosis在OA软骨退变中的研究作一综述,以期为揭示TMJOA病变机制提供新的认识。

关键词: 颞下颌关节, 骨关节炎, 软骨退变, 程序性坏死, 损伤相关分子模式

Abstract: Temporomandibular osteoarthritis (TMJOA) is a severe form of temporomandibular disorder (TMD). Articular cartilage degeneration is one of the most typical pathological features in primary TMJOA, and chondrocyte death is the core event in cartilage degeneration. Compared with apoptosis and autophagy, the release of damage associated molecular patterns (DAMPs) after the occurrence of necroptosis, which is a new type of cell death, do further harm to chondrocytes and cartilage extracellular matrix. The TNF-α-Necroptosis-DAMPs-TNF-α vicious circle may result in extensive destruction to cartilage. Therefore, this article briefly reviews related researches on necroptosis in cartilage degeneration of OA in order to provide new understanding concerning the pathogenesis of TMJOA.

Key words: TMJ, OA, cartilage degeneration, Necroptosis, DAMPs

何峰, 于世宾. 程序性坏死在颞下颌关节骨关节炎软骨退变中的研究进展[J]. 口腔医学研究, 2021, 37(1): 15-18.

HE Feng, YU Shibin. Research Progress of Necroptosis on Cartilage Degeneration in TMJOA[J]. Journal of Oral Science Research, 2021, 37(1): 15-18.

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程序性坏死在颞下颌关节骨关节炎软骨退变中的研究进展

Research Progress of Necroptosis on Cartilage Degeneration in TMJOA

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