口腔医学研究

口腔医学研究 ›› 2021, Vol. 37 ›› Issue (10): 924-926.DOI: 10.13701/j.cnki.kqyxyj.2021.10.013

• 口腔颌面外科学研究 • 上一篇    下一篇

致密性成骨不全继发颌骨骨髓炎临床分析及治疗探讨

刘华联   

  1. 常州市第一人民医院口腔颌面外科 江苏 常州 213004
  • 收稿日期:2021-02-22 出版日期:2021-10-28 发布日期:2021-10-18
  • 作者简介:刘华联(1983~ ),男,安徽阜阳人,硕士,副主任医师,研究方向:口腔颌面部肿瘤的基础及临床研究,E-mail:565263166@qq.com。
  • 基金资助:
    常州市卫生局指导性课题(项目编号:WZ201206)

Clinical Analysis and Treatment Exploration of Mandibular Pycnodysostosis Complicated with Osteomyelitis

LIU Hualian   

  1. Department of Oral and Maxillofacial Surgery, The First People's Hospital of Changzhou, Changzhou 213004, China
  • Received:2021-02-22 Online:2021-10-28 Published:2021-10-18

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摘要： 目的:通过对致密性成骨不全(pycnodysostosis)继发颌骨骨髓炎病例回顾性分析及手术方式探讨,提高此类疾病的临床诊疗水平。方法:对2013年6月~2015年6月桑给巴尔Nnazi Mmoja医院收治的致密性成骨不全继发颌骨骨髓炎患者进行回顾性分析,总结患者的临床病史、影像学资料、治疗方法及随访资料。结果:共有5例患者诊断为致密性成骨不全继发颌骨骨髓炎,经过合理的抗生素治疗及颌骨病灶死骨搔刮或切除后,患者红细胞沉降率、C反应蛋白及血常规均恢复正常,随访12~24个月,临床治愈率80%(4/5),复发1例。结论:致密性成骨不全病例较为罕见,口腔颅颌面表征可作为该疾病与其他遗传性骨病鉴别诊断的要点。抗生素治疗和病灶颌骨部分切除术可作为致密性成骨不全继发颌骨骨髓炎患者的首选方法。

关键词: 致密性成骨不全, 颌骨, 骨髓炎, 手术治疗, 回顾性分析

Abstract: Objective: To improve the level of clinical diagnosis and treatment by retrospective analyzing the case of osteomyelitis secondary to pycnodysostosis. Methods: A retrospective analysis was conducted on osteomyelitis secondary to pycnodysostosis in Nnazi Mmoja Hospital of Zanzibar from June 2013 to June 2015. The clinical data, imaging data, treatment methods, and follow-up data of patients were analyzed. Results: After treatment by antibiotics and sequestrum scraping or resection of dead bone, the normal values of ESR, CRP and blood routine were obtained. Four out of five patients were cured, while 1 patient showed recurrence within 12 to 24 months' follow-up. Conclusion: Pycnodysostosis is rare. Oral craniomaxillofacial characterization can be used as a key point for differential diagnosis of the pycnodysostosis. Antibiotic therapy and resection of dead bone in jaw lesions may be the preferred method for patients with pycnodysostosis secondary to osteomyelitis of jaw.

Key words: pycnodysostosis, mandible, osteomyelitis, surgical procedures, retrospective analysis