PDGF/PDGFRβ信号通路耦合成骨成血管作用的研究进展

doi:10.13701/j.cnki.kqyxyj.2022.02.004

口腔医学研究 ›› 2022, Vol. 38 ›› Issue (2): 113-115.DOI: 10.13701/j.cnki.kqyxyj.2022.02.004

PDGF/PDGFRβ信号通路耦合成骨成血管作用的研究进展

苏晗, 唐国华^*

上海交通大学医学院附属第九人民医院口腔正畸科;上海交通大学口腔医学院;国家口腔医学中心;国家口腔疾病临床医学研究中心;上海市口腔医学重点实验室上海 200011

收稿日期:2020-11-18 出版日期:2022-02-28 发布日期:2022-02-23
通讯作者: *唐国华,E-mail:drtanggh@163.com
作者简介:苏晗(1996~ ),男,四川人,硕士在读,研究方向:口腔正畸学。
基金资助:
上海市自然科学基金(编号:19ZR1429600)

Research Progress on PDGF/PDGFRβ Pathway Coupling with Osteogenesis and Angiogenesis

SU Han, TANG Guohua^*

Department of Orthodontics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Institute of Stomatology, Shanghai 200011, China

Received:2020-11-18 Online:2022-02-28 Published:2022-02-23

摘要/Abstract

摘要： 骨的生长发育和修复重建过程中,成血管作用与成骨作用不可或缺,二者耦联是骨形成的关键因素。血小板衍生生长因子受体β属于第三类受体酪氨酸激酶,同相应的血小板衍生生长因子相结合后,通过下游信号级联反应,参与多种细胞和组织的生理活动。近年来随着组织工程与再生医学的广泛研究,不同学者发现该通路可以参与微血管系统和成骨细胞系的活动调节,表明该通路对于成骨成血管的耦合具有重要作用。

关键词: 血小板衍生生长因子, 血小板衍生生长因子受体β, 成骨, 成血管

Abstract: Osteogenesis and angiogenesis are indispensable to development and regeneration of bone, and their coupling is a crucial factor in bone formation. Platelet-derived growth factor receptor beta (PDGFRβ) belongs to the class Ⅲ receptor tyrosine kinase, which participates in a variety of physiological activities in cells and tissues through the downstream signal cascade, after the combination with corresponding platelet-derived growth factors (PDGFs). With broader studies on tissue engineering and regenerative medicine, the participation of such pathway in the regulation of activities of microvascular system and osteoblast lineage has been founded by various scholars, indicating that PDGF/PDGFRβ pathway plays an important role in the coupling of osteogenesis and angiogenesis.

Key words: PDGF, PDGFRβ, osteogenesis, angiogenesis

苏晗, 唐国华. PDGF/PDGFRβ信号通路耦合成骨成血管作用的研究进展[J]. 口腔医学研究, 2022, 38(2): 113-115.

SU Han, TANG Guohua. Research Progress on PDGF/PDGFRβ Pathway Coupling with Osteogenesis and Angiogenesis[J]. Journal of Oral Science Research, 2022, 38(2): 113-115.

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PDGF/PDGFRβ信号通路耦合成骨成血管作用的研究进展

Research Progress on PDGF/PDGFRβ Pathway Coupling with Osteogenesis and Angiogenesis

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