口腔医学研究

口腔医学研究 ›› 2022, Vol. 38 ›› Issue (10): 981-985.DOI: 10.13701/j.cnki.kqyxyj.2022.10.017

• 口腔病理学研究 • 上一篇    下一篇

14例成釉细胞癌临床资料分析

袁壮1,2, 罗号2, 吴开柳3, 贺捷3*, 孟箭1,2*   

  1. 1.徐州医科大学徐州临床学院徐州市中心医院口腔科 江苏 徐州 221004;
    2.徐州医科大学口腔医学院 江苏 徐州 221000;
    3.上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科,上海市口腔医学重点实验室/上海市口腔医学研究所,国家口腔疾病临床研究中心 上海 200011
  • 收稿日期:2021-09-17 出版日期:2022-10-28 发布日期:2022-10-20
  • 通讯作者: *贺捷,E-mail:hejie2310@126.com;孟箭,E-mail: mrocket@126.com
  • 作者简介:袁壮(1995~ ),男,江苏徐州人,硕士在读,住院医师,研究方向:口腔颌面外科。
  • 基金资助:
    国家自然科学基金(编号:31400859);上海市自然科学基金(编号:19ZR1429900);国家口腔疾病临床医学研究中心项目(编号:NCRCO-202101)

Clinical Analysis of 14 Cases of Ameloblastic Carcinoma

YUAN Zhuang1,2, LUO Hao2, WU Kailiu3, HE Jie3*, MENG Jian1,2*   

  1. 1. Department of Stomatology, Xuzhou Clinical College of Xuzhou Medical University, Xuzhou 221004, China;
    2. School of Stomatology, Xuzhou Medical University, Xuzhou 221000, China;
    3. Department of Oral and Maxillofacial-Head and Neck Surgery, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology; National Clinical Research Center of Stomatology, Shanghai 200011, China
  • Received:2021-09-17 Online:2022-10-28 Published:2022-10-20

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摘要： 目的: 通过分析临床病例、查阅文献,探讨成釉细胞癌的临床表现、诊断及治疗。方法: 对上海交通大学医学院附属第九人民医院2010~2018年收治的病理诊断明确为成釉细胞癌的14例患者的临床资料进行分析。结果: 14例中,男10例,女4例,男女比例为2.5∶1;发病年龄15~71岁,平均发病年龄40.9岁;病灶位于上颌骨6例,下颌骨8例,上下颌骨比例为0.75∶1;均行手术治疗,随访0.5~7年,9例复发,其中1例出现颈部淋巴结转移,2例术后出现肺转移。结论: 成釉细胞癌是一种罕见的牙源性恶性肿瘤,继发性成釉细胞癌多由重复手术干预导致。成釉细胞癌复发率与病灶位置、治疗方式密切相关,目前手术扩大根治仍然是成釉细胞癌的首选治疗方法,术后长期随访是必要的。

关键词: 成釉细胞癌, 临床表现, 诊断, 治疗

Abstract: Objective: To explore the clinical characteristics, diagnosis, and treatment of ameloblastic carcinoma (AC) by analyzing clinical cases and reviewing the literature. Methods: The clinical data of 14 patients with AC were retrospectively analyzed. Results: There were 10 male and 4 female patients included in this study, with a male-to-female ratio of 2.5∶1. Their ages ranged from 15 to 71 years and the mean age was 40.9 years. Six patients' lesion location was maxilla and 8 patients' was mandible, and the maxilla-to-mandible ratio was 0.75∶1. All patients were subjected to surgical resection and followed-up for 0.5-7 years to record recurrence. There were 9 recurrences in the case series, of which 1 had cervical lymph node metastasis, and 2 had lung metastasis after surgery. Conclusion: AC is a rare neoplasm of the odontogenic epithelium. Secondary AC is mostly caused by repeated surgical intervention. Recurrence rate of AC is closely related to lesion location and treatment. At present, extended surgical resection is still the preferred treatment and postoperative long-time followed-up is necessary.

Key words: ameloblastic carcinoma, clinical manifestations, diagnosis, treatment