深冻同种异体骨在口腔颌面骨缺损修复中的应用进展

doi:10.13701/j.cnki.kqyxyj.2025.09.003

摘要/Abstract

摘要： 自体骨是口腔颌面骨组织缺损修复的“金标准”,然而自体骨移植需要开辟第二术区且骨量有限。同种异体骨因其良好的骨传导性和成骨作用被认为是替代自体骨的良好选择。深冻同种异体骨是经深低温冷冻、辐照等处理后长期储存于-80 ℃环境中的骨移植材料,具有与自体骨相似的成骨效果与机械性能,近年来在外科及口腔颌面外科等领域应用广泛。本文总结近十年来深冻骨在口腔颌面部骨修复领域的研究进展和临床应用情况,内容涵盖了深冻骨的制备技术、基础研究进展和深冻骨在口腔颌面骨缺损修复中的临床应用及其效果等多个方面。

关键词: 同种异体骨, 牙槽嵴缺损, 骨增量, 上颌窦提升术, 骨移植

Abstract: Autologous bone is the 'gold standard' for the repair of oral and maxillofacial bone defects. However, autogenous bone grafting requires the creation of a second surgical area and has limited bone volume. Allograft bone is considered to be a good alternative to autogenous bone because of its good osteoconductivity and osteogenesis. Deep frozen allogeneic bone is a bone substitute material that stored at -80 ℃ for a long period of time after deep cryogenic freezing and irradiation, which has similar osteogenic effect and mechanical properties as autogenous bone, and has been widely used in the fields of surgery and oral and maxillofacial surgery in recent years. This paper summarizes the research progress and clinical application of deep-frozen allograft in the field of oral and maxillofacial bone repair in the past decade, covering the preparation technology of deep-frozen allograft, the progress of basic research, and the clinical application of deep-frozen bone in the repair of oral and maxillofacial bone defects and its cinical application effect.

Key words: allograft bone, alveolar ridge defect, bone augmentation, maxillary sinus lift, bone grafting

唐卿炜, 杨帆. 深冻同种异体骨在口腔颌面骨缺损修复中的应用进展[J]. 口腔医学研究, 2025, 41(9): 750-754.

TANG Qingwei, YANG Fan. Advances in Use of Deep-frozen Allogeneic Bone in Repair of Oral and Maxillofacial Bone Defects[J]. Journal of Oral Science Research, 2025, 41(9): 750-754.

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