富白细胞和血小板纤维蛋白用于不同难度系数的下颌第三磨牙拔除术的回顾性研究

doi:10.13701/j.cnki.kqyxyj.2026.01.007

摘要/Abstract

摘要： 目的: 探讨富白细胞和血小板纤维蛋白(leukocyte-platelet-rich fibrin,L-PRF)对不同难度下颌第三磨牙拔除术后疼痛、肿胀及软组织愈合的影响。方法: 回顾性收集2021年11月~2022年10月于我院接受下颌第三磨牙拔除术的患者146例,根据手术记录分为PRF组(拔牙窝内放置L-PRF)和常规组(自然愈合),比较两组患者术后疼痛、肿胀、软组织愈合情况。结果: PRF组术后1、2、3 d疼痛、肿胀显著低于常规组(P<0.05),PRF组术后7 d软组织愈合指数显著低于常规组(P<0.01),中难度亚型差异显著(P<0.05)。结论: 研究表明,L-PRF在中难度下颌第三磨牙拔除术中效果最佳,显著减轻术后疼痛、肿胀,改善软组织愈合。

关键词: 富白细胞和血小板纤维蛋白, 第三磨牙, 疼痛, 肿胀, 软组织愈合

Abstract: Objective: To investigate the effects of leukocyte-platelet-rich fibrin (L-PRF) on postoperative pain, swelling, and soft tissue healing following extraction of mandibular third molars with varying difficulty levels. Methods: This retrospective study analyzed 146 consecutive cases of mandibular third molar extraction performed at our institution between November 2021 and October 2022. Patients were stratified into two groups based on surgical records: the PRF group (receiving L-PRF placement in the extraction socket) and the control group (undergoing natural healing without biomaterial intervention). Comparative assessments of postoperative pain, swelling, and soft tissue healing parameters were conducted between the groups. Results: The PRF group exhibited statistically significant reductions in both pain and swelling scores at postoperative days 1, 2, and 3 compared to the control group (P<0.05). Furthermore, the PRF group demonstrated superior soft tissue healing outcomes at day 7 postoperatively, as evidenced by significantly lower healing index scores (P<0.01). These therapeutic advantages were particularly pronounced in cases of moderate surgical difficulty (P<0.05). Conclusion: L-PRF application yields optimal clinical benefits in moderately difficult mandibular third molar extractions, demonstrating significant efficacy in mitigating postoperative pain and swelling while promoting enhanced soft tissue healing.

Key words: leukocyte-and platelet-rich fibrin, third molar, pain, swelling, soft tissue healing

卜柯宇, 胡海莼, 黄煦涵, 欧阳君毅, 邹海啸. 富白细胞和血小板纤维蛋白用于不同难度系数的下颌第三磨牙拔除术的回顾性研究[J]. 口腔医学研究, 2026, 42(1): 35-40.

BU Keyu, HU Haichun, HUANG Xuhan, OUYANG Junyi, ZOU Haixiao. Retrospective Study on Application of L-PRF in Extraction of Mandibular Third Molars with Different Levels of Difficulty[J]. Journal of Oral Science Research, 2026, 42(1): 35-40.

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