口腔医学研究

口腔医学研究 ›› 2015, Vol. 31 ›› Issue (10): 1017-1019.

• 临床研究论著 • 上一篇    下一篇

99Tcm-MIBI SPECT-CT融合显像在腮腺区良恶性肿瘤鉴别的应用价值

刘洪伟1,李宁毅2*   

  1. 1. 济宁市第一人民医院口腔颌面外科 山东 济宁 272000;
    2. 青岛大学医学院附属医院口腔颌面外科 山东 青岛 266003
  • 收稿日期:2015-03-13 出版日期:2015-10-28 发布日期:2016-05-04
  • 通讯作者: 李宁毅,电话:(0532)2911341
  • 作者简介:刘洪伟(1975~ ),男,山东省汶上人,副主任医师,硕士,主要从事口腔科的临床治疗工作。
  • 基金资助:
    山东省济宁市科技发展计划项目(编号:200956220)

Application of 99Tcm-MIBI SPECT-CT for Differential Diagnosis of Benign and Malignant Parotid Tumors

LIU Hong-wei1, LI Ning-yi2*   

  1. 1. Department of Oral and Maxillofacial Sugery, Jining First People’s Hospital, Jining 272000, China;
    2. Department of Nuclear Medicine, Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China
  • Received:2015-03-13 Online:2015-10-28 Published:2016-05-04

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摘要： 目的:探讨锝(99mTc)甲氧异腈(99mTc-methoxyisobutylisonitrile 99Tcm-MIBI)SPECT-CT在腮腺肿块术前定性诊断的价值。方法:对30例单侧腮腺肿块患者术前行腮腺区SPECT-CT显像,以99Tcm-MIBI为显像剂,所有病例均行融合显像判断肿块性质。定性分析行χ2检验、放射性摄取比值(T/N)行t检验。判断结果分别与临床检查、病理诊断相比较。结果:99Tcm-MIBI SPECT-CT对腮腺区肿块诊断的敏感性、特异性、准确性分别为84.61%、94.12%、90.00%。17例腮腺良性肿块,其中16例阴性(94.11%,16/17),1例显示假阳性(5.89%,1/17)。99Tcm-MIBI SPECT-CT融合显像13例腮腺恶性肿瘤显示12例阳性(92.31%,12/13),1例淋巴瘤出现假阴性(7.69%)。定性分析经χ2检验有统计学意义。计算腮腺区良恶性肿块放射性摄取比值(T/N)(1.42±0.62),(2.32±0.58),经t检验两者差别有统计学意义(P＜0.05)。结论:99Tcm-MIBI SPECT-CT对鉴别腮腺区良恶性肿块有良好的应用价值。

关键词: 腮腺肿瘤, 放射性同位素, 体层摄影术, SPECT-CT

Abstract: Objective: To evaluate the clinical application of 99Tcm-methoxyisobutylis-onitrile (99Tcm-MIBI) SPECT-CT for differential diagnosis of benign and malignant parotid tumors before treatment. Methods: SPECT-CT fusion images of parotid regions were obtained from 30 patients with unilateral parotid gland tumor before surgery. 99mTc-MIBI was used as the imaging agent. The results were compared with their pathological diagnoses and clinical examination. The chi-square test and t-test were used for statistical analysis. Results: The sensitivity, specificity and accuracy of 99Tcm-MIBI SPECT-CT fusion imaging in determining the malignant parotid tumors were 84.61%, 94.12% and 90.00%, respectively. Sixteen of 17 patients with benign tumors showed negative images (94.11%, 16/17), while 1 of 17 patients showed positive images (5.89%, 1/17). In addition, 12 of 13 patients with malignant tumors showed positive images (92.31%, 12/13), while 1 of 13 patients showed negative image (7.69%, 1/13). There were significant differences between two groups by chi-square test. The uptake ratios of benign and malignant parotid tumors were 1.42±0.6 and 2.32±0.58 (P＜0.05), respectively. Conclusion: 99Tcm-MIBI SPECT-CT might be a useful method for differential diagnosis of benign and malignant parotid tumors before treatment.

Key words: Parotid neoplasms, Radioisotopes, Tomography, SPECT-CT

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