口腔医学研究

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (4): 390-395.DOI: 10.13701/j.cnki.kqyxyj.2017.04.011

• 临床研究论著 • 上一篇    下一篇

多联抗生素糊剂与Vitapex治疗乳牙牙髓病及根尖周病疗效的系统评价

房瑞贞, 高磊, 吴礼安*   

  1. 军事口腔医学国家重点实验室,口疾病国家临床医学研究中心,第四军医大学口腔医学院儿童口腔科 陕西 西安 710032
  • 收稿日期:2016-10-16 出版日期:2017-04-20 发布日期:2017-04-24
  • 通讯作者: 吴礼安,电话:029-84776087
  • 作者简介:房瑞贞(1990~ ),女,山东潍坊,硕士,主要从事儿童牙病学研究工作。
  • 基金资助:
    国家自然科学基金(编号:81170929)

Comparison of Curative Effect of Polyantibiotic Paste and Vitapex for Pulp Infection and Periradicular Lesion of Primary Teeth: a Systematic Review.

FANG Rui-zhen, GAO lei, WU Li-an*.   

  1. State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Departmet of Pediatric Dentistry, School of Stomatology, the Fourth Military Medical University, Xi’an, 710032 China.
  • Received:2016-10-16 Online:2017-04-20 Published:2017-04-24

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摘要： 目的:系统评价多联抗生素糊剂与Vitapex用于乳牙牙髓病及根尖周病的疗效。方法:计算机检索Cochrane Library 、EMbase 、PubMed、CBM、CNKI及VIP数据库,检索从建库到2016年6月30日国内外公开发表的关于比较多联抗生素糊剂与Vitapex治疗乳牙牙髓及根尖周病的随机对照试验,由2名研究者根据纳入及排除标准独立筛选文献、提取数据并对纳入文献进行方法学质量评价,最后采用RevMan 5.0软件进行Meta分析,Stata 12.0进行发表偏倚的衡量。结果:最终纳入16个研究3852颗牙齿。Meta分析结果显示,整体成功率[RR=1.02,95%CI(1.00-1.04),Z=1.85,P=0.06]及12个月成功率[RR=1.01,95%CI(0.98-1.03),Z=0.60,P=0.55]比较差异无统计学意义,6个月成功率[RR=1.02,95%CI(1.00-1.04),Z=2.15,P=0.03]及24个月及以上成功率[RR=1.07,95%CI(1.01-1.12),Z=2.42,P=0.02]比较差异有统计学意义。结论:对于乳牙根管治疗,多联抗生素糊剂与Vitapex具有可比性,且随访2年及以上的长期效果较Vitapex更稳定。

Abstract: Objective: To compare the curative effect of polyantibiotic paste and Vitapex for primary teeth of pulp infection and periradicular lesions by systematical review. Methods: The data up to June 30, 2016 were collected by searching in Cochrane Library, EMbase, PubMed, CBM, CNKI and VIP. Two reviewers independently screened the literatures according to the inclusion and exclusion criteria and extracted data from the literatures. The methodological quality of selected studies was assessed. The RevMan 5.0 software was used for Meta-analysis and the Stata 12.0 was for evaluating the publication bias. Results: A total of 16 studies were selected and 3852 teeth were involved. The results of Meta-analysis showed that the total successful rate between two groups [RR=1.02, 95%CI (1.00-1.04), Z=1.85, P=0.06] and the successful rate of 12 months [RR=1.01, 95%CI (0.98-1.03), Z=0.60, P=0.55] were not significantly different; the successful rate of 6 months [RR=1.02, 95%CI (1.00-1.04), Z=2.15, P=0.03] and the successful rate of over 24 months [RR=1.75, 95%CI (1.11-2.76), Z=2.42, P=0.02] were significantly different. Conclusion: Compared with the curative effect of Vitapex for primary teeth of pulp infection and periradicular lesions, the successful rate of polyantibiotic paste was superior, especially for the cases observed over two years.

Key words: Polyantibiotic paste , Vitapex , Primary teeth , Pulp infection , Periradicular lesions , Systematic review, Meta-analysis

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