TP63相互作用蛋白分析

doi:10.13701/j.cnki.kqyxyj.2016.06.009

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (6): 588-591.DOI: 10.13701/j.cnki.kqyxyj.2016.06.009

TP63相互作用蛋白分析

白忠诚¹ ,汪鑫² ,尹伟^2* ,边专²

1. 湖北医药学院附属随州医院·随州市中心医院口腔科湖北随州 441300;
2. 武汉大学口腔医学院,湖北省口腔基础医学重点实验室-省部共建国家重点实验室培育基地湖北武汉 430079

收稿日期:2016-01-26 出版日期:2016-06-26 发布日期:2016-06-22
通讯作者: 尹伟,电话:027-87646337
作者简介:白忠诚(1965~ ),男,湖北人,学士,副主任医师,主要从事牙体牙髓相关疾病研究。
基金资助:
国家自然科学基金(编号:81470727;81501750)
湖北省口腔基础医学重点实验室-省部共建国家重点实验室培育基地开放研究基金(编号:201402)

Bioinformatic Analysis of TP63-related Proteins

BAI Zhong-cheng¹, WANG Xin², YIN Wei^2*, BIAN Zhuan².

1. Suizhou Central Hospital; Affiliated Hospital of Hubei University of Medicine, Suizhou 441300, China;
2. State Key Laboratory Breeding Base of Oral Basic Science, Hospital and School of Stomatology, Wuhan University, Wuhan 430079, China.

Received:2016-01-26 Online:2016-06-26 Published:2016-06-22

摘要/Abstract

摘要： 目的:分析先天缺牙和唇/腭裂综合征相关蛋白--TP63蛋白的相互作用分子,并对其生物学功能进行分析。方法:利用生物信息学数据库(STRING)分析和预测TP63蛋白的相互作用蛋白。在DAVID数据库对相互作用蛋白的生物学功能进行分析。结果:对STRING数据库预测的TP63蛋白50个相互作用蛋白的生物学功能分析显示,TP63相互作用分子主要参与对细胞增殖和凋亡的调节。结论:生物信息学分析初步揭示了TP63蛋白的相互作用网络及其生物学功能。

关键词: TP63, 相互作用, 蛋白质, 生物学功能, 生物信息学

Abstract: Objective: To analyze the interactive molecules of TP63 which is related to hypodontia and cleft lip/palate. Methods: The interactive molecules of TP63 were predicted by the STRING database. The molecular biology function was determined by the DAVID database. Results: The STRING database predicted 50 genes that correlated with TP63. Most of them were involved in the cell proliferation and apoptosis process. Conclusion: Bioinformatic analysis tentatively explored the interactive network of TP63 protein.

中图分类号:

R596

白忠诚 ,汪鑫 ,尹伟 ,边专. TP63相互作用蛋白分析[J]. 口腔医学研究, 2016, 32(6): 588-591.

BAI Zhong-cheng, WANG Xin, YIN Wei, BIAN Zhuan.. Bioinformatic Analysis of TP63-related Proteins[J]. Journal of Oral Science Research, 2016, 32(6): 588-591.

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TP63相互作用蛋白分析

Bioinformatic Analysis of TP63-related Proteins

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