口腔医学研究

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (6): 592-595.DOI: 10.13701/j.cnki.kqyxyj.2016.06.010

• 临床研究论著 • 上一篇    下一篇

冠心病患者牙齿缺失数目与颈动脉病变相关性的临床研究

续彩霞 ,王丙娜 ,陈青 ,石学雪 ,马千惠 ,任秀云*   

  1. 山西医科大学口腔医学系 山西 太原 030001
  • 收稿日期:2015-11-23 出版日期:2016-06-26 发布日期:2016-06-22
  • 通讯作者: 任秀云,电话:0351-4690450
  • 作者简介:续彩霞(1976~ ),女,山西太原人,硕士,主治医师,主要从事牙周病的临床治疗工作。
  • 基金资助:
    国家自然科学基金项目(编号:81271144、31050002)

Correlation between the Number of Teeth Missing and Carotid Artery Lesions in Patients with Coronary Heart Disease

XU cai-xia, WANG bing-na, CHEN qing, SHI xue-xue, MA qian-hui, REN xiu-yun.   

  1. Department of Stomatology, Shanxi Medical University, Taiyuan 030001, China
  • Received:2015-11-23 Online:2016-06-26 Published:2016-06-22

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摘要： 目的:通过对冠心病住院患者进行问卷调查和口腔检查,初步探讨牙周炎与动脉粥样硬化之间的相关性。方法:选择经病史和冠状动脉造影确诊为冠心病的患者,详细记录其人口特征、血压、糖尿病病史、心血管病史、血脂系列结果以及口腔情况。颈动脉超声检测颈动脉内中膜厚度(carotidarteryintima-mediathickness,CIMT)及斑块情况。结果:非条件Logistic回归分析结果显示缺牙数目与斑块发生存在正相关(OR=1.298,95%CI:1.100-1.531,P=0.002);简单线性回归分析结果显示缺牙数目与CIMT存在线性关系,回归系数b=0.041。缺牙数目与斑块直径之间存在相关关系,相关系数rs=0.519,P<0.001。缺牙数目与血脂各项指标之间无统计学意义。结论:对于本研究人群(冠心病住院患者),随着缺牙数目的增加,颈动脉斑块的发生率增加,颈动脉内中膜厚度及斑块的大小也增加,这表明牙周炎导致的牙齿缺失可能是动脉粥样硬化疾病的一个重要的风险指标。

关键词: 牙周炎, 动脉粥样硬化, 缺牙数目, 颈动脉内中膜厚度, 动脉斑块

Abstract: Objective: To explore the correlation between periodontitis and atherosclerosis by taking the questionnaire survey and oral examination in patients with coronary heart disease (CHD). Methods: Demographic characteristics, blood pressure, the history of diabetes and cardiovascular disease, lipid series results and oral situation of patients with coronary heart disease were recorded. The carotid artery intima-media thickness (CIMT) and atheromatous plaques were detected by carotid ultrasound. Results: The number of teeth missing was positively correlated with occurrence rate of plaques (OR=1.298, 95%CI: 1.100-1.531, P=0.002). There was significant linear correlation between the number of teeth missing and CIMT (b=0.041). The correlation between the number of teeth missing and the diameter of the plaque was statistically significant(r=0.519, P<0.001). There was no significant difference between the number of teeth missing and levels of blood lipid (P>0.05). Conclusion: It is suggested that teeth missing caused by periodontitis might be a risk factor for atherosclerosis.

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