口腔医学研究

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (8): 861-864.DOI: 10.13701/j.cnki.kqyxyj.2016.08.021

• 临床研究论著 • 上一篇    下一篇

白芍总苷配伍枸杞治疗口腔扁平苔藓患者的疗效评价

李阳1,刘思佳2,常缨3,王婷婷3,李贞3,王婧娇3,张敬3,王丽3,漆明3*   

  1. 1. 宁夏医科大学研究生学院 宁夏 银川 750004;2. 宁夏医科大学口腔医学院 宁夏 银川 750004;
    3. 宁夏医科大学总医院口腔医院 宁夏 银川 750004
  • 收稿日期:2015-12-14 出版日期:2016-08-26 发布日期:2016-08-26
  • 通讯作者: 漆明,E-mail:qiming61@sina.com
  • 作者简介:李阳(1988~ ),男,宁夏人,硕士在读,主要从事口腔黏膜病学研究,现在宁夏医科大学口腔医学院工作。

Curative Effect of Total Glucosides of Paeony Combined with Wolfberry in the Treatment of Olp

Yang1,LIU Si-jia2,CHANG Ying3,WANG Ting-ting3, LI Zheng3, WANG Jing-jiao3,ZHANG Jing3, WANG Li3, QI Ming3*   

  1. 1. Postgraduate Education College, Ningxia Medical University, Yinchuan 750004, China;
    2. School of Stomatology, Ningxia Medical University, Yinchuan 750004, China;
    3. Hospital of Stomatology, General Hospital of Ningxia Medical University, Yinchuan 750004, China.
  • Received:2015-12-14 Online:2016-08-26 Published:2016-08-26

摘要： 目的:评价白芍总苷配伍枸杞治疗口腔扁平苔藓(OLP)患者临床疗效、不良反应及免疫功能的变化。方法:口腔扁平苔藓患者70例随机分为两组,分别为白芍总苷配伍枸杞治疗组和白芍总苷治疗组,观察、比较两组治疗2个月后的临床疗效、免疫功能的变化及用药期间的不良反应。结果:白芍总苷配伍枸杞治疗组总有效率为88.57%,白芍总苷治疗组总有效率为68.57%,白芍总苷配伍枸杞治疗组疗效显著优于白芍总苷组(P<0.05),不良反应轻(P<0.05);同时白芍总苷配伍枸杞治疗组较白芍总苷治疗组OLP患者的补体C3、C4、CD3+细胞数升高(P<0.05)。结论:白芍总苷配伍枸杞治疗口腔扁平苔藓患者疗效显著,能较好地调节OLP患者的机体免疫状况,不良反应轻微。

关键词: 白芍总苷, 枸杞, 免疫功能, 口腔扁平苔藓

Abstract: Objective: To evaluate the clinical efficacy, the adverse reactions and the changes of the immunity state of OLP patients treated with total glucosides of paeony (TGP) combined with wolfberry. Methods: Seventy OLP patients were randomly divided into two groups: one group with oral TGP capsules and Wolfberry; the other group with oral TGP capsules. The clinical efficacy, the adverse reactions and the changes of the immune function were observed after two months. Results: The total effective rate was 88.57% in the combined group, and the total effective rate was 68.57% in the TGP group. The clinical efficacy was better in the combined group with less adverse reaction (P<0.05). However, the numbers of the C3, C4, CD3+ cells were increased (P<0.05). Conclusion: Per os TGP combined with Wolfberry showed better therapeutic effect, mild adverse reactions, and might regulate the immunity function of OLP patients.

Key words: Total glucosides of paeony, Wolfberry, Immune function, Oral lichen planus

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