口腔医学研究

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (5): 513-516.DOI: 10.13701/j.cnki.kqyxyj.2016.05.022

• 临床研究论著 • 上一篇    下一篇

白细胞相关免疫球蛋白样受体-2和转化生长因子-β在口腔扁平苔藓患者外周血表达及意义

陈冶   

  1. 武汉市汉阳医院口腔科 湖北 武汉 430053
  • 收稿日期:2015-09-02 出版日期:2016-05-26 发布日期:2016-05-26
  • 作者简介:陈冶(1971~ ),男,湖南湘潭人,副主任医师,学士,主要从事口腔科的临床治疗工作,E-mail:1564570864@qq. com。

Expressions and Significances of Leukocyte-associated Immunoglobulin-like Receptor 2 and Transforming Growth Factor-β in Peripheral Blood of Patients with Oral Lichen Planus.

CHEN Ye.   

  1. Department of Stomatology, Hanyang Hospital. Wuhan 430053, China
  • Received:2015-09-02 Online:2016-05-26 Published:2016-05-26

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摘要： 目的:探讨白细胞相关免疫球蛋白样受体-2(LAIR-2)和转化生长因子-β(TGF-β)在口腔扁平苔藓患者外周血表达及意义。方法:选取53例口腔扁平苔藓患者和50例健康者,利用流式细胞仪检测外周血Treg细胞上LAIR-2表达,利用ELISA法对血清中TGF-β水平进行检测。结果:LAIR-2在口腔扁平苔藓患者外周血Treg细胞上阳性表达率为(4.62±0.33)%,显著低于对照组的(6.47±0.28)%,差异有统计学意义(P<0.05);口腔扁平苔藓患者外周血中TGF-β水平显著高于对照组,差异有统计学意义(P<0.05);Pearson相关分析显示,口腔扁平苔藓患者外周血Treg细胞上LAIR-2阳性表达和TGF-β水平呈负相关(r=-0.416,P=0.011)。结论:LAIR-2在口腔扁平苔藓患者外周血Treg细胞中呈低表达,而外周血TGF-β水平升高,二者可能共同参与了T细胞介导免疫抑制作用,与口腔扁平苔藓发生及进展有关。

关键词: 口腔扁平苔藓, 外周血, 白细胞相关免疫球蛋白样受体-2, 转化生长因子-β, 表达

Abstract: Objective: To investigate the expressions and significances of leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) and transforming growth factor-β (TGF-β) in peripheral blood of patients with oral lichen planus. Methods: 53 cases of oral lichen planus patients and 50 healthy people were selected. The expression of LAIR-2 in peripheral regulatory T cells was tested using flow cytometry. The level of TGF-β in plasma was detected by ELISA method. Results: The expression rate of LAIR-2 in peripheral regulatory T cells of oral lichen planus patients was (4.62±0.33)%, which was significantly lower than (6.47±0.28)% of the control group (P<0.05). The level of TGF-β in peripheral blood of oral lichen planus patients was significantly higher than that of the control group (P<0.05). Pearson correlation analysis showed that the positive expression of LAIR-2 in peripheral of oral lichen planus patients was negatively correlated with the levels of TGF-β (r=-0.416, P=0.011). Conclusion: The expression of LAIR-2 in regulatory T cells in peripheral blood of oral lichen planus patients was reduced, but the levels of TGF-β was elevated. This might relate to the inhibition of T cell-mediated immunity and relate to the occurrence and progression of oral lichen planus.

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