变异链球菌葡萄糖基转移酶转录调控因子的研究进展

doi:10.13701/j.cnki.kqyxyj.2017.07.026

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (7): 792-794.DOI: 10.13701/j.cnki.kqyxyj.2017.07.026

变异链球菌葡萄糖基转移酶转录调控因子的研究进展

仇元新^*, 方绍伟, 秦宗长

天津市口腔医院牙体牙髓病科天津 300041

收稿日期:2016-01-18 出版日期:2017-07-20 发布日期:2017-07-27
通讯作者: 仇元新,电话:13752592440
作者简介:仇元新(1982~ ),女,山东泰安人,硕士研究生,副主任医师,主要从事牙体牙髓病的诊治工作。
基金资助:
天津市卫技委科技基金(编号:2015KY24)

Research Progress of Regulator of Streptococcus Mutans Glucosyltransferase.

QIU Yuan-xin^*, FANG Shao-wei, QIN Zong-chang.

Stomatology Hospital of Tianjing Stomatological Hospital. Tianjing 300041, China.

Received:2016-01-18 Online:2017-07-20 Published:2017-07-27

摘要/Abstract

摘要： 葡萄糖基转移酶是变异链球菌自身合成的一种重要的固有酶,是变异链球菌重要的致龋因子,它以蔗糖作为代谢底物,合成生物膜重要的胞外多糖葡聚糖,葡聚糖一方面介导细菌蔗糖依赖的生物膜形成,另一方面当外源性糖源缺乏时,被降解供细菌继续代谢。因此可以通过控制葡萄糖基转移酶而控制龋病的发生发展。本文就变异链球菌葡萄糖基转移酶基因转录的调控因子作一综述。

关键词: 变异链球菌, 葡萄糖基转移酶, 基因转录, 调控因子

Abstract: Glucosyltransferase (GTF) is secreted by streptococcus mutans inhabited in the oral cavity. It synthesizes glucans which provide binding sites for a succession of bacteria on hard surfaces. Therefore, inhibition of formation and accumulation of cariogenic biofilm communities by affecting glucosyltransferase is an attractive route to prevent both dental caries. This article reviews the regulators of gene transcription of glucosyltransferase.

Key words: Streptococcus mutans, Glucosyltransferase, Gene transcription , Regulator

中图分类号:

R780.1

仇元新, 方绍伟, 秦宗长. 变异链球菌葡萄糖基转移酶转录调控因子的研究进展[J]. 口腔医学研究, 2017, 33(7): 792-794.

QIU Yuan-xin, FANG Shao-wei, QIN Zong-chang.. Research Progress of Regulator of Streptococcus Mutans Glucosyltransferase.[J]. Journal of Oral Science Research, 2017, 33(7): 792-794.

参考文献

[1] Yamashita Y, Bowen WH, Burne RA, et al. Role of the Streptococcus mutans gtf gene in caries induction in the Specific-Pathogen-Free rat model [J]. Infect Immun, 1993, 61(9)∶3811-3817
[2] M Matsumoto, S Hamada, T Ooshima. Molecular analysis of the inhibitory effects of oolong tea polyphenols on glucan-binding domain of recombinant glucosyltransferases from Streptococcus mutans MT8148,FEMS Microbiol Lett, 2003 ,228(1)∶73-80
[3] Santosh Pandit, Ga-Ram Kim, Min-Ho Lee, et al. Evaluation of Streptococcus mutans biofilms formed on fluoride releasing and non fluoride releasing resin composites [J]. Journal of Dentistry, 2011, 39(11)∶780-787
[4] Xin Xu, Xue D. Zhou, Christine D. Wu. Tea catechin epigallocatechin gallate inhibits Streptococcus mutans biofilm formation by suppressing gtf genes [J]. Archives of Oral Biology,2012,57(6)∶678-683
[5] Akira Yano, Sayaka Kikuchi, Tohru Takahashi, et al. Inhibitory effects of the phenolic fraction from the pomace of Vitis coignetiae on biofilm formation by Streptococcus mutans [J]. Archives of Oral Biology, 2012,57(6)∶711-719
[6] Ru Zhang, Wanmei Zhang, Tao H. Dextran glucosidase: A potential target of iminosugars in caries prevention [J]. Medical Hypotheses,2011,76(4)∶574-575
[7] Terao Y, Isoda R, Murakami J, et al. Molecular and biological characterization of gtf regulation-associated genes in Streptococcus mutans [J]. Oral Microbiol Immunol, 2009, 24(3)∶211-217
[8] Tsumori H;Kuramitsu H,The role of the Streptococcus mutans glucosyltransferases in the sucrose-dependent attachment to smooth surfaces: essential role of the GtfC enzyme [J]. Oral Microbiol Immunol,1997,12(5)∶274 -280
[9] L.F. Espinosa-Cristbal, G.A. Martínez-Castaón, E.J. Tllez-Dctor et al,Adherence inhibition of Streptococcus mutans on dental enamel surface using silver nanoparticles [J]. Materials Science and Engineering: C, 2013, 33(4)∶2197-2202
[10] Neusa L. Figueiredo, Sara Raquel M.M. de Aguiar, Pedro Luis Falé, Lia Ascenso, Maria Luisa M. Serralheiro, Ana Rosa L. The inhibitory effect of Plectranthus barbatus and Plectranthus ecklonii leaves on the viability, glucosyltransferase activity and biofilm formation of Streptococcus sobrinus and Streptococcus mutans [J]. Food Chemistry, 2010,119(2)∶664-668
[11] Renata O Mattos Graner, Marcelo H Napimoga, Kasuo Fukushima, et al. Comparative analysis of Gtf isozyme production and diversity in isolates of streptococcus mutans with different biofilm growth phenotypes,Journal of Clinical Microbiology, 2004,42(10)∶4586-4592
[12] Suk-Ho Ban, Young-Ran Kwon, Santosh Pandit, et al. Effects of a bio-assay guided fraction from Polygonum cuspidatum root on the viability, acid production and glucosyltranferase of mutans streptococci [J]. Fitoterapia, 2010, 81(1)∶30-34
[13] Zezhang T Wen, Prashanth Suntharaligham, Dennis G Cvitkovitch, et al. Trigger factor in Streptococcus mutans is involved in stress tolerance, competence development and biofilm formation [J]. INFECTION AND IMMUNITY, 2005, 73(1)∶219-225
[14] Stock, A. M., V. L. Robinson, and P. N. Goudreau. 2000. Two-component signal transduction [J]. Annu. Rev. Biochem, 69∶183-215
[15] Miki Matsuo, Hitoshi Komatsuzawa, Role of Two-component System of Streptococcus mutans in the Adaptive Response to the Oral Environment [J]. Journal of Oral Biosciences, 2010, 52(3)∶252-259
[16] M Dilani Senadheera, Bernard Guggenheim, Grace A Spatafora, et al. A VicRK Signal Transduction System in Streptococcus mutans Affects gtfBCD, gbpB and ftf Expression, Biofilm Formation and Genetic Competence Development [J]. Journal of Microbiology, 2005,187(12)∶4064-4076
[17] Zhiyan He, Qian Wang, Yuejian Hu, et al. Use of the quorum sensing inhibitor furanone C-30 to interfere with biofilm formation by Streptococcus mutans and its luxS mutant strain. International Journal of Antimicrobial [J]. Agents, 2012, 40(1)∶30-35
[18] Bing Wang, Howard K, Kuramitsu, A Pleiotropic Regulator, Frp. Affects Exopolysaccharide Synthesis, Biofilm Formation and Competence [J]. Development in Streptococcus mutans, Infection and Immunity, 2006, 74(8)∶4581-4589
[19] Saswati Biswas, Indranil Biswas. Role of HtrA in Surface Protein Expression and Biofilm Formation by Streptococcus mutans [J]. Infection and Immunity,2005,73(10)∶6923-6934
[20] Christopher M Browngardt, Zezhang T Wen, Robert A Burne. RegM is required for optimal fructosyltransferase and glucosyltransferase gene expression in Streptococcus mutans [J]. FEMS Microbiology Letters, 2004, 240(1)∶75-79
[21] N. Taniguchi, K. Nakano, R. Nomura, S. Naka, A. Kojima, M. Matsumoto, T. Ooshima, Defect of glucosyltransferases reduces platelet aggregation activity of Streptococcus mutans: Analysis of clinical strains isolated from oral cavities [J]. Archives of Oral Biology, 2010, 55(6)∶410-416

变异链球菌葡萄糖基转移酶转录调控因子的研究进展

Research Progress of Regulator of Streptococcus Mutans Glucosyltransferase.

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