基于实时荧光定量聚合酶链反应技术预测龋病发生的研究进展

doi:10.13701/j.cnki.kqyxyj.2019.01.003

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (1): 13-15.DOI: 10.13701/j.cnki.kqyxyj.2019.01.003

基于实时荧光定量聚合酶链反应技术预测龋病发生的研究进展

孙同正^1,2, 杨芳^2*

1. 青岛市第九人民医院口腔科青岛市市立医院西院区口腔科山东青岛 266002;
2. 青岛大学附属青岛市市立医院口腔科山东青岛 266071

收稿日期:2018-03-28 出版日期:2019-01-18 发布日期:2019-01-28
通讯作者: 杨芳,E-mail:fancy-yf@163.com
作者简介:孙同正(1991~ ),男,山东沂南人,硕士,主要从事口腔内科的临床治疗工作。
基金资助:
国家自然科学基金(编号:81670979、31600099);青岛市自助创新计划(应用基础研究项目-青年专项)资助项目(编号:16-5-1-67-jch);广东省口腔医学重点实验室开放课题基金资助(编号:KF2016120101)

Research Progress in Prediction of Dental Caries Based on FQ-PCR

SUN Tong-zheng^1,2, YANG Fang^2*

1. Department of Stomatology, The Ninth People's Hospital of Qingdao, Qingdao 266002, China;
2. Department of Stomatology, Affiliated Qingdao City Hospital, Qingdao 266071, China

Received:2018-03-28 Online:2019-01-18 Published:2019-01-28

摘要/Abstract

摘要： 龋病是发生在牙体组织的慢性感染性疾病,呈进行性不可逆进展,最终导致牙体组织缺损或丧失。龋病在人群中发病率极高,严重影响患者的生活质量,因此针对龋病的病因学研究及预防就显得尤其重要。实时荧光定量聚合酶链反应(real-time fluorescent quantitative polymerase chain reaction, FQ-PCR)技术,可对龋病的病因学及发病机制进行定量研究,发现与龋病密切相关的菌群,并为龋病的预防和治疗策略提供新的思路。

关键词: 龋病, 变异链球菌, 白色念珠菌, 乳酸杆菌, 实时荧光定量聚合酶链反应

Abstract: Dental caries is a chronic infectious disease that occurs in dental tissues. It develops in a progressive irreversible manner and eventually leads to the defect or loss of dental tissues. Caries is extremely high incidence in the population, affecting the patient's life quality seriously. It is critical to study the etiology of caries and prevention. FQ-PCR can quantitatively study the etiology and pathogenesis of dental caries and find out the micro-flora closely related to dental caries and provide a new method for the prevention and treatment of dental caries.

Key words: Caries, Streptococcus mutans, Candida albicans, Lactobacillus, FQ-PCR

孙同正, 杨芳. 基于实时荧光定量聚合酶链反应技术预测龋病发生的研究进展[J]. 口腔医学研究, 2019, 35(1): 13-15.

SUN Tong-zheng, YANG Fang. Research Progress in Prediction of Dental Caries Based on FQ-PCR[J]. Journal of Oral Science Research, 2019, 35(1): 13-15.

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基于实时荧光定量聚合酶链反应技术预测龋病发生的研究进展

Research Progress in Prediction of Dental Caries Based on FQ-PCR

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