3D打印多孔钛个性化根形种植体的体内骨愈合研究

doi:10.13701/j.cnki.kqyxyj.2018.12.018

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (12): 1337-1341.DOI: 10.13701/j.cnki.kqyxyj.2018.12.018

3D打印多孔钛个性化根形种植体的体内骨愈合研究

秦风利,王超,刘婷,喻缇,黄元丁^*

重庆医科大学附属口腔医院种植科重庆 400010

收稿日期:2018-04-25 出版日期:2018-12-28 发布日期:2018-12-27
通讯作者: 黄元丁,E-mail:xinyueblue2018@163.com
作者简介:秦风利(1992~ ),女,重庆人,硕士在读,主要从事口腔种植学研究。

Bone Healing of Customized 3D Printed Porous Titanium Root-analogue Implants in Vivo

QIN Feng-li, WANG Chao, LIU Ting, YU Ti, HUANG Yuan-ding^*

Stomatological Hospital, Chongqing Medical University, Chongqing 400010, China.

Received:2018-04-25 Online:2018-12-28 Published:2018-12-27

摘要/Abstract

摘要： 目的: 观察不同设计方式的3D打印多孔钛个性化根形种植体在体内的骨愈合效果,为此新型种植体的研发提供参考依据。方法: 利用CBCT影像技术、逆向工程、计算机辅助设计等技术设计了3组具有不同结构的多孔钛个性化根形种植体。通过3D打印技术制作的多孔钛个性化根形种植体通过手术的方式植入比格犬颌骨内。3个月后,获取比格犬颌骨标本,通过X线片、Micro-CT和硬组织切片染色等方法观察种植体骨结合情况。结果: 动物术后大体观察、影像学和组织学检测均显示此个性化种植体在体内具有良好的生物安全性,骨组织长入多孔结构内部,种植体与周围骨组织均产生骨结合。3组个性化种植体中,A组单根式种植体成骨效果最好,其次为C组分根式,成骨效果最差的是B组多根联合式。结论: 通过比格犬动物体内实验证明此3D打印多孔钛个性化根形种植体在动物体内均能够达到良好的骨结合,其中采用单根式或分根式植入成果效果最好。

关键词: 3D打印, 多孔钛, 根形种植体

Abstract: Objective: To observe the bone healing effect of customized 3D printed porous titanium root-analogue implants with different designs in the body.Methods: By using CBCT imaging, reverse engineering, and computer aided design technology, the porous titanium root analogue implants were personalized designed.Then the porous titanium root analogue implants with appropriate pore diameter, porosity, and connectivity were produced by DMLS technique with high precision.The individualized implants were implanted in the beagle jaw.After three months, the bone healing was observed by X-ray film, micro-CT, and histology slices.Results: Through postoperative gross observation, radiographic and histologic examination, the personalized implants had good biological safety in the body.The bone grew into porous titanium structure and osseointegration was showed around bone and implant.Single root implant in group A had the best result.The effect of radical patterns implant in group C was modest.Root-connected patterns implant in group B had the worst result.Conclusion: The 3D printed porous titanium root-analogue implant can achieve complete osseointegration and good bio-safety in vivo.It might be used in the immediate implantation.

Key words: 3D printing, Porous titanium, Root-analogue implants

秦风利,王超,刘婷,喻缇,黄元丁. 3D打印多孔钛个性化根形种植体的体内骨愈合研究[J]. 口腔医学研究, 2018, 34(12): 1337-1341.

QIN Feng-li, WANG Chao, LIU Ting, YU Ti, HUANG Yuan-ding. Bone Healing of Customized 3D Printed Porous Titanium Root-analogue Implants in Vivo[J]. Journal of Oral Science Research, 2018, 34(12): 1337-1341.

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3D打印多孔钛个性化根形种植体的体内骨愈合研究

Bone Healing of Customized 3D Printed Porous Titanium Root-analogue Implants in Vivo

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