口腔医学研究

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (9): 898-901.DOI: 10.13701/j.cnki.kqyxyj.2019.09.019

• 口腔生物学与口腔材料学研究 • 上一篇    下一篇

核壳状CHX/ACP纳米球改性流体树脂的体外释药研究

徐泽先1,2, 杨彦伟2,3, 邱宜农2, 李志强4, 王学锋1, 王锐1, 郑欣4, 刘斌1*   

  1. 1. 兰州大学口腔医学院 甘肃 兰州 730000;
    2. 中国人民解放军联勤保障部队第940医院口腔科 甘肃 兰州 730050;
    3. 军事口腔医学国家重点实验室,空军军医大学口腔医学院 陕西 西安 710032;
    4. 西北民族大学口腔医学国家民委重点实验室,甘肃省口腔疾病研究重点实验室,口腔医学院 甘肃 兰州 730030
  • 收稿日期:2019-01-25 出版日期:2019-09-28 发布日期:2019-09-25
  • 通讯作者: 刘斌, E-mail: liubkq@lzu.edu
  • 作者简介:徐泽先(1993~ ),男,山东青岛人,硕士,医师,主要从事口腔材料学方面的研究。
  • 基金资助:
    国家自然科学基金(编号:81701029);甘肃省科技计划(编号:17JR5RA335);军事口腔医学国家重点实验室自主研究课题(编号:2016KB02)

In Vitro Drug Release of Dental Flow Resin Modified by Core-shell Shaped CHX/ACP Nanospheres

XU Zexian1,2, YANG Yanwei2,3, QIU Yinong2, LI Zhiqiang4, WANG Xuefeng1, WANG Rui1, ZHENG Xin4, LIU Bin1*   

  1. 1. School of Stomatology, Lanzhou University, Lanzhou 730050, China;
    2. The 940th Hospital of Joint Logistic Support Force of PLA, Lanzhou 730050, China;
    3. State Key Laboratory of Military Stomatology, School of Stomatology, The Air Force Military Medical University, Xi’an 710032, China;
    4. Key Lab of Stomatology of State Ethnic Affairs Commission,Key Lab of Oral Diseases of Gansu Province, School of Stomatology, Northwest Minzu University, Lanzhou 730030, China
  • Received:2019-01-25 Online:2019-09-28 Published:2019-09-25

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摘要： 目的:研究核壳状氯己定/无定形磷酸钙纳米球(CHX/ACP) 改性商品流体树脂的体外释药性能。方法:合成核壳状CHX/ACP纳米球并进行表征。将纳米球以不同质量分数(1%、5%、10%)添加至FiltekTM Z350XT流体树脂中作为实验组,商品流体树脂作为对照组,制备各组试件浸取液,并在不同时间点检测其钙、磷离子和CHX的释放量。结果:3组改性流体树脂在去离子水中均能持续释放钙、磷离子和CHX,且其释放量随纳米球添加比例的增加而显著增大,也随浸泡时间的延长而增大,其释放速率随时间延长而减慢;而对照组的钙、磷离子和CHX的释放量近于0,且不随时间变化。结论:3组CHX/ACP纳米球改性的流体树脂均具有缓释钙、磷离子和CHX的能力,纳米球添加量对药物释放量有显著影响。

关键词: 核壳状纳米球, 氯己定, 无定形磷酸钙, 口腔复合树脂

Abstract: Objective: To investigate the in vitro drug release of dental flow resin (FiltekTM Z350XT Flow Resin) modified by chlorhexidine/amorphous calcium phosphate (CHX/ACP) nanospheres with core-shell structure. Methods: The core-shell CHX/ACP nanospheres was synthesized and characterized. Nanospheres were added to FiltekTM Z350XT flow resin in different mass percentages (1%, 5%, and 10%) as experimental group, but unmodified flow resin as control group. The sample leaching solutions were prepared and the releases of calcium, phosphorus, and CHX at different time points were measured. Results: Three groups of experimental resins continuously released calcium, phosphorus, and CHX in deionized water. The release amounts all significantly increased with the increase of the added proportion of nanospheres, and also increased with the prolongation of soaking time. The release rate decreased with time. The release of the control group was approximately zero and did not change with time. Conclusion: Flow resin with different proportions of core-shell CHX/ACP can continuously release calcium,phosphorus, and CHX slowly. The addition proportion of nanoparticles has a significant effect on drug release.

Key words: anospheres with core-shell structure, chlorhexidine, amorphous calcium phosphate, dental flow resin