牙髓干细胞分化中微小RNA的调控作用及其机制的研究进展

doi:10.13701/j.cnki.kqyxyj.2021.02.005

摘要/Abstract

摘要： 牙髓干细胞(dental pulp stem cells, DPSCs)是一种神经嵴来源的成体干细胞,具有良好的自我更新及多向分化特性,可向多种口腔组织相关细胞分化,且兼具免疫原性低等优势,因此作为种子细胞在组织工程及再生医学领域广泛应用。微小RNA(microRNA, miRNA)是一类通过作用于基因转录后RNA而调控靶基因表达的短链非编码RNA,在细胞生长、增殖、胚胎发育、组织分化和凋亡等多种生命活动中发挥重要调节作用。本文对DPSCs分化过程中微小RNA调节作用及其机制进行综述。

关键词: 微小RNA, 干细胞, 分化

Abstract: Dental pulp stem cells are stem cells derived from neural crest with good self-renewal and multi-directional differentiation characteristics. They can differentiate into a variety of oral tissue related cells with low immunogenicity. It has been widely used as seed cells in tissue engineering and regenerative medicine fields. MicroRNA is a kind of short chain non-coding RNA that regulates the expression of target genes by acting on post-transcriptional RNA, which plays an important role in all aspects of life activities, such as cell growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis. In this paper, we review the regulatory role and mechanism of microRNA in the differentiation of dental pulp stem cells.

Key words: microRNA, stem cells, differentiation

赵云, 米方林. 牙髓干细胞分化中微小RNA的调控作用及其机制的研究进展[J]. 口腔医学研究, 2021, 37(2): 113-117.

ZHAO Yun, MI Fanglin. Research Progress on Regulation and Mechanism of microRNA on Dental Pulp Stem Cell Differentiation[J]. Journal of Oral Science Research, 2021, 37(2): 113-117.

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