卵黄高磷蛋白调控生物玻璃对牙本质的再矿化

doi:10.13701/j.cnki.kqyxyj.2021.02.007

口腔医学研究 ›› 2021, Vol. 37 ›› Issue (2): 122-125.DOI: 10.13701/j.cnki.kqyxyj.2021.02.007

卵黄高磷蛋白调控生物玻璃对牙本质的再矿化

俞少玲, 臧睿觉, 李姮^*

南京大学医学院附属口腔医院,南京市口腔医院儿童口腔科江苏南京 210008

收稿日期:2020-08-24 发布日期:2021-02-11
通讯作者: 李姮,E-mail: lh.7466@163.com
作者简介:俞少玲(1978~ ),女,江苏南京人,硕士,副主任医师,主要从事儿童口腔科工作。
基金资助:
南京市科技发展计划项目(编号:201803034)

Regulation of Phosvitin on Remineralization of Demineralized Dentin by Bioactive Glass

YU Shaoling, ZANG Ruijue, LI Heng^*

Department of Paediatric Dentistry,Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, China

Received:2020-08-24 Published:2021-02-11

摘要/Abstract

摘要： 目的:探讨卵黄高磷蛋白(PV)调控生物活性玻璃对脱矿牙本质再矿化的能力。方法:制备120片牙本质切片,随机分为6组,A组为对照组(SBF模拟体液),B组为100 mg/L PV,C组为500 mg/L PV,D组为SBF+生物活性玻璃(BG),E组为100 mg/L PV+BG组,F组为500 mg/L PV+BG组。模拟口腔温度处理30 d后,扫描电镜(SEM)观察牙本质表面的显微结构并测量表面显微硬度值(SMH)。结果:E组和F组与其余各组SMH值均有统计学差异(P<0.01),但两组间无显著差异(P＞0.05), C组和D组与A组比较有统计学差异(P＜0.05)。SEM观察显示各组均有沉积物形成,E组和F组沉积物更加均匀致密。结论:卵黄高磷蛋白(PV)可以促进牙本质表面矿物质的形成,与BG联合应用可有加强协同作用。

关键词: 卵黄高磷蛋白, 再矿化, 显微硬度, 牙本质

Abstract: Objective: To investigate the regulation of phosvitin (PV) on remineralization of demineralized dentin by bioactive glass (BG). Methods: 120 dentin slices were prepared and randomly divided into 6 groups: Group A was treated with SBF as the control group, Group B was treated with 100 mg/L PV, Group C was treated with 500 mg/L PV, Group D was treated with SBF and BG, Group E was treated with 100 mg/L PV and BG, and Group F was treated with 500 mg/L PV and BG. After simulated oral temperature treatment for 30 days, the microstructure of dentin surface was observed by scanning electron microscope (SEM) and the values of surface microhardness (SMH) was measured. Results: The SMH values of group E and F were significantly different from those of other groups(P＜0.01),but there was no significant difference between two groups(P＞0.05). SMH value of group C or D was significantly different from that of group A(P＜0.05). Remineralization were observed in all groups, and the sediments of group E and F were more uniform and tighter. Conclusion: PV can promote the remineralization on the dentin surface, and the combination of PV and BG achieves the synergistic effect.

Key words: phosvitin, remineralization, microhardness, dentin

俞少玲, 臧睿觉, 李姮. 卵黄高磷蛋白调控生物玻璃对牙本质的再矿化[J]. 口腔医学研究, 2021, 37(2): 122-125.

YU Shaoling, ZANG Ruijue, LI Heng. Regulation of Phosvitin on Remineralization of Demineralized Dentin by Bioactive Glass[J]. Journal of Oral Science Research, 2021, 37(2): 122-125.

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卵黄高磷蛋白调控生物玻璃对牙本质的再矿化

Regulation of Phosvitin on Remineralization of Demineralized Dentin by Bioactive Glass

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