乙醇酸对牙釉质和牙本质进行酸蚀的研究进展

doi:10.13701/j.cnki.kqyxyj.2023.11.002

摘要/Abstract

摘要： 在树脂粘接修复的过程中,牙釉质和牙本质的表面处理是关键步骤。目前,传统酸蚀剂常用的磷酸是一种强酸,容易对牙本质造成侵蚀性脱矿,影响树脂-牙本质粘接界面的长期稳定性。近年来,有研究将乙醇酸作为一种替代酸蚀剂,本文将介绍乙醇酸的应用背景和酸蚀原理,重点针对使用乙醇酸酸蚀牙釉质和牙本质的酸蚀效果及与传统磷酸酸蚀相比的优势做一综述,以期为后续的临床研究提供参考。

关键词: 乙醇酸, 酸蚀剂, 牙釉质, 牙本质, 粘接强度

Abstract: In the process of resin-bonded restoration, the surface treatment of enamel and dentin is a key step. At present, phosphoric acid commonly used in the clinic is a strong acid, which has an aggressive pattern of demineralization of dentin, and affects the long-term stability of the resin-dentin adhesive interface. In recent years, glycolic acid has been used as an alternative etch agent. This paper introduces the application background and the principle of glycolic acid etching, focuses on the effect of glycolic acid etching on enamel and dentin and the comparison between glycolic acid and traditional phosphoric acid, in order to provide reference for further research.

Key words: glycolic acid, etchant, enamel, dentin, bond strength

林令康, 朱松. 乙醇酸对牙釉质和牙本质进行酸蚀的研究进展[J]. 口腔医学研究, 2023, 39(11): 952-955.

LIN Lingkang, ZHU Song. Research Progress of Glycolic Acid for Enamel and Dentin Etching[J]. Journal of Oral Science Research, 2023, 39(11): 952-955.

参考文献

[1] Buonocore MG. A simple method of increasing the adhesion of acrylic filling materials to enamel surfaces[J]. J Dent Res, 1955, 34(6): 849-853.
[2] Sofan E, Sofan A, Palaia G, et al. Classification review of dental adhesive systems: from the Ⅳ generation to the universal type[J]. Ann Stomatol (Roma), 2017, 8(1): 1-17.
[3] Wang Y, Ding N, Zong Z, et al. Etch-mineralizing treatment to improve dentin bonding[J]. J Dent, 2022, 126: 104305.
[4] Somrit P, Tantilertanant Y, Srisawasdi S. Primer application technique and remaining dentin thickness affected microtensile bond strength of contemporary dentin adhesives under simulated pulp pressure[J]. Clin Oral Investig, 2023, 27(1): 139-149.
[5] Godfrey PD, Rodgers FM, Brown RD. Theory versus experiment in jet spectroscopy: Glycolic acid[J]. J Am Chem Soc, 1997, 119(9): 2232-2239.
[6] Green BA, Yu RJ, Van Scott EJ. Clinical and cosmeceutical uses of hydroxyacids[J]. Clin Dermatol, 2009, 27(5): 495-501.
[7] Tang SC, Yang JH. Dual effects of alpha-hydroxy acids on the skin[J]. Molecules, 2018, 23(4): 863.
[8] Lee KC, Wambier CG, Soon SL, et al. Basic chemical peeling: Superficial and medium-depth peels[J]. J Am Acad Dermatol, 2019, 81(2): 313-324.
[9] Bernstein EF, Lee J, Brown DB, et al. Glycolic acid treatment increases type Ⅰ collagen mRNA and hyaluronic acid content of human skin[J]. Dermatol Surg, 2001, 27(5): 429-433.
[10] Narda M, Trullas C, Brown A, et al. Glycolic acid adjusted to pH 4 stimulates collagen production and epidermal renewal without affecting levels of proinflammatory TNF-alpha in human skin explants[J]. J Cosmet Dermatol, 2021, 20(2): 513-521.
[11] Venkataraman KJ, Boominathan SK, Nagappan R, et al. Efficacy of glycolic acid on debris and smear removal as a final rinse solution in curved canals: A scanning electron microscope study[J]. J Pharm Bioallied Sci, 2021, 13(Suppl 2): S1603-S1608.
[12] Barcellos D, Farina AP, Barcellos R, et al. Effect of a new irrigant solution containing glycolic acid on smear layer removal and chemical/mechanical properties of dentin[J]. Sci Rep, 2020, 10(1): 7313.
[13] Cecchin D, Bringhenti IL, Bernardi JB, et al. Alpha-hydroxy glycolic acid for root dentin etching: Morphological analysis and push out bond strength[J]. Int J Adhes Adhes, 2019, 90: 138-143.
[14] Hua X, Cao R, Zhou X, et al. One-step continuous/semi-continuous whole-cell catalysis production of glycolic acid by a combining bioprocess with in-situ cell recycling and electrodialysis[J]. Bioresour Technol, 2019, 273: 515-520.
[15] Xie CZ, Healy T, Russell J. EDTA in the environment: with special reference to the dairy industry[J]. Int J Environ Waste Manag, 2007, 1(4): 351-362.
[16] Yoshida Y, Van Meerbeek B, Nakayama Y, et al. Adhesion to and decalcification of hydroxyapatite by carboxylic acids[J]. J Dent Res, 2001, 80(6): 1565-1569.
[17] Yoshioka M, Yoshida Y, Inoue S, et al. Adhesion/decalcification mechanisms of acid interactions with human hard tissues[J]. J Biomed Mater Res, 2002, 59(1): 56-62.
[18] Janusz W, Skwarek E. Adsorption of the tartrate ions in the hydroxyapatite/aqueous solution of NaCl System[J]. Materials (Basel), 2021, 14(11): 3039.
[19] Chien YC, Burwell AK, Saeki K, et al. Distinct decalcification process of dentin by different cariogenic organic acids: Kinetics, ultrastructure and mechanical properties[J]. Arch Oral Biol, 2016, 63: 93-105.
[20] Vidal CMP, LaRoy C, Chagas Toledo D, et al. Hydroxy acids for adhesion to enamel and dentin: Long-term bonding performance and effect on dentin biostability[J]. J Dent, 2021, 107: 103613.
[21] DeRocher KA, Smeets PJM, Goodge BH, et al. Chemical gradients in human enamel crystallites[J]. Nature, 2020, 583(7814): 66-71.
[22] Trevelin LT, Villanueva J, Zamperini CA, et al. Investigation of five α-hydroxy acids for enamel and dentin etching: Demineralization depth, resin adhesion and dentin enzymatic activity[J]. Dent Mater, 2019, 35(6): 900-908.
[23] Cecchin D, Farina AP, Vidal C, et al. A novel enamel and dentin etching protocol using alpha-hydroxy glycolic acid: Surface property, etching pattern, and bond strength studies[J]. Oper Dent, 2018, 43(1): 101-110.
[24] Barkmeier WW, Erickson RL, Kimmes NS, et al. Effect of enamel etching time on roughness and bond strength[J]. Oper Dent, 2009, 34(2): 217-222.
[25] Aung S, Takagaki T, Ikeda M, et al. Ultra-morphological studies on enamel-universal adhesive interface[J]. J Dent, 2021, 104: 103527.
[26] Han F, Jin X, Yuan X, et al. Interactions of two phosphate ester monomers with hydroxyapatite and collagen fibers and their contributions to dentine bond performance[J]. J Dent, 2022, 122: 104159.
[27] Bello YD, Farina AP, Souza MA, et al. Glycolic acid: Characterization of a new final irrigant and effects on flexural strength and structural integrity of dentin[J]. Mater Sci Eng C Mater Biol Appl, 2020, 106: 110283.
[28] Marafiga FA, Barbosa AFA, Silva E, et al. Effect of glycolic acid and EDTA on dentin mechanical properties[J]. Aust Endod J, 2022, 48(1): 27-31.
[29] Maso PC, Souza MA, Borba M, et al. Influence of photodynamic therapy, different final irrigants, and ultrasonic activation on the bond strength of glass fiber posts to root dentin[J]. Photodiagnosis Photodyn Ther, 2022, 40: 103180.
[30] Souza MA, Trentini BM, Parizotto TF, et al. Influence of a glycolic acid-based final irrigant for photosensitizer removal of photodynamic therapy on the microhardness and colour change of the dentin structure[J]. Photodiagnosis Photodyn Ther, 2021, 33: 102151.
[31] Bello YD, Porsch HF, Farina AP, et al. Glycolic acid as the final irrigant in endodontics: Mechanical and cytotoxic effects[J]. Mater Sci Eng C Mater Biol Appl, 2019, 100: 323-329.
[32] Trevelin LT, Villanueva J, Zamperini CA, et al. Investigation of five alpha-hydroxy acids for enamel and dentin etching: Demineralization depth, resin adhesion and dentin enzymatic activity[J]. Dent Mater, 2019, 35(6): 900-908.
[33] Trevelin LT, Alania Y, Mathew M, et al. Effect of dentin biomodification delivered by experimental acidic and neutral primers on resin adhesion[J]. J Dent, 2020, 99: 103354.
[34] Porto I, Nascimento TG, Oliveira JMS, et al. Use of polyphenols as a strategy to prevent bond degradation in the dentin-resin interface[J]. Eur J Oral Sci, 2018, 126(2): 146-158.
[35] Mazzoni A, Nascimento FD, Carrilho M, et al. MMP activity in the hybrid layer detected with in situ zymography[J]. J Dent Res, 2012, 91(5): 467-472.
[36] Maravic T, Breschi L, Paganelli F, et al. Endogenous enzymatic activity of primary and permanent dentine[J]. Materials (Basel), 2021, 14(14): 4043.
[37] Amaral SFD, Scaffa PMC, Rodrigues RDS, et al. Dynamic influence of pH on metalloproteinase activity in human coronal and radicular dentin[J]. Caries Res, 2018, 52(1-2): 113-118.
[38] DeVito-Moraes AG, Francci C, Vidal CM, et al. Phosphoric acid concentration affects dentinal MMPs activity[J]. J Dent, 2016, 53: 30-37.
[39] Banerjee S, Amin SA, Jha T. A fragment-based structural analysis of MMP-2 inhibitors in search of meaningful structural fragments[J]. Comput Biol Med, 2022, 144: 105360.
[40] Moore KM, Girens RE, Larson SK, et al. A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease[J]. Neurobiol Dis, 2016, 85: 218-224.
[41] Peng M, Yang D, Hou Y, et al. Intracellular citrate accumulation by oxidized ATM-mediated metabolism reprogramming via PFKP and CS enhances hypoxic breast cancer cell invasion and metastasis[J]. Cell Death Dis, 2019, 10(3): 228.
[42] Tang SC, Tang LC, Liu CH, et al. Glycolic acid attenuates UVB-induced aquaporin-3, matrix metalloproteinase-9 expression, and collagen degradation in keratinocytes and mouse skin[J]. Biochem J, 2019, 476(10): 1387-1400.
[43] Hashimoto M, Ohno H, Endo K, et al. The effect of hybrid layer thickness on bond strength: demineralized dentin zone of the hybrid layer[J]. Dent Mater, 2000, 16(6): 406-411.