口腔医学研究

口腔医学研究 ›› 2024, Vol. 40 ›› Issue (4): 371-374.DOI: 10.13701/j.cnki.kqyxyj.2024.04.018

• 研究生病例精粹——口腔黏膜病系列(4) • 上一篇    

脱落细胞DNA定量分析技术动态监测口腔扁平苔藓伴上皮异常增生病情及光动力治疗1例

董冰洁1,2, 刘泽燏1,2, 李婷1,2, 周刚1,2, 卢锐1,2*   

  1. 1.口颌系统重建与再生全国重点实验室,口腔生物医学教育部重点实验室,口腔医学湖北省重点实验室,武汉大学口腔医(学)院 湖北 武汉 430079;
    2.武汉大学口腔医院口腔黏膜科 湖北 武汉 430079
  • 收稿日期:2024-03-06 发布日期:2024-04-22
  • 通讯作者: *卢锐,E-mail:lurui@whu.edu.cn
  • 作者简介:董冰洁(1999~ ), 女, 河南商丘人, 硕士在读, 研究方向:口腔黏膜病学。
  • 基金资助:
    武汉大学护理专项科研培育基金项目(编号:600400018)

Dynamic Monitoring of Oral Lichen Planus with Epithelial Dysplasia and Effect of Photodynamic Therapy Using DNA Content Analysis of Exfoliated Cells: A Case Report

DONG Bingjie1,2, LIU Zeyu1,2, LI Ting1,2, ZHOU Gang1,2, LU Rui1,2*   

  1. 1. State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China;
    2. Department of Oral Medicine, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China
  • Received:2024-03-06 Published:2024-04-22

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摘要： 口腔扁平苔藓是一种临床上常见的慢性炎性口腔黏膜病,具有癌变风险,临床上应积极干预并随访监测。光动力治疗具有微创、有效、选择性好以及可重复性高等优势,在治疗口腔扁平苔藓中已显现出良好疗效,但其疗效评估方法仍然存在局限性。脱落细胞DNA定量分析技术是一种无创辅助检查手段,可用于口腔潜在恶性疾患癌变及口腔癌的早筛早诊。本文报道1例采用脱落细胞DNA定量分析技术动态监测口腔扁平苔藓癌变风险及光动力治疗疗效的诊疗过程,以期为建立口腔扁平苔藓伴上皮异常增生的精准微创诊疗体系提供参考。

关键词: 脱落细胞DNA定量分析, 口腔扁平苔藓, 上皮异常增生, 光动力治疗

Abstract: Oral lichen planus (OLP) is a common chronic inflammatory oral mucosal disease with a risk of malignant transformation, which required active intervention and close follow-up and monitoring. Photodynamic therapy (PDT) has been widely used in the treatment of OLP due to its advantages of minimally invasive, effective, good selectivity, and repeatability. However, there are still limitations in the efficacy evaluation approaches of PDT for OLP. DNA quantitative analysis of exfoliated cells is a non-invasive auxiliary examination method, which can be used for the early screening and diagnosis of the malignancy of oral potentially malignant disorders and oral cancer. Here we reported a case of OLP with epithelial dysplasia using DNA content analysis of exfoliated cells to dynamically monitor the risk of malignancy and the effect of PDT. The aim of this report is to provide a reference for establishing the precise and minimally invasive diagnosis and treatment of OLP with epithelial dysplasia.

Key words: DNA content analysis of exfoliated cells, oral lichen planus, epithelial dysplasia, photodynamic therapy