巨噬细胞介导的骨免疫在种植体植入后骨整合中的作用及其机制研究

doi:10.13701/j.cnki.kqyxyj.2025.03.003

摘要/Abstract

摘要： 种植体治疗成功的关键是种植体与牙槽骨之间形成良好的骨整合。而巨噬细胞的可塑性在成骨及愈合的各个阶段起关键作用,参与种植体植入后骨整合。目前,有关巨噬细胞可塑性的机制尚未明确,需进一步探索免疫细胞之间及其与巨噬细胞之间的相互作用,寻找极化可逆性靶点。本综述通过归纳巨噬细胞的起源、分类、极化可塑性和功能,总结其对种植体植入后的骨免疫调控作用,并从骨免疫层面阐述种植体植入后骨整合的机制,为设计具有良好骨免疫作用的种植体植入物提供理论依据,从而降低种植体植入失败的风险。

关键词: 巨噬细胞, 骨免疫, 骨整合, 种植体, 免疫调节

Abstract: The key to successful implant therapy is the formation of good osseointegration between the implant and the alveolar bone. Macrophage plasticity, however, plays a key role in all stages of osteogenesis and healing, and is involved in osseointegration after implant placement. Currently, the mechanisms behind macrophage plasticity are unclear, and further exploration of the interactions between immune cells and between them and macrophages is needed to search for targets of polarization reversibility. In this review, by summarizing macrophage origin, classification, polarization plasticity, and function, their role in regulating bone immunity after implant placement is concluded and the mechanism of osseointegration after implant placement from the osteoimmune level is elaborated, which will provide a theoretical basis for the design of implants with good osteoimmune effects, thus reducing the risk of implant placement failure.

Key words: macrophages, osteoimmunology, osseointegration, implants, immunomodulation

李丛丛, 赵莉. 巨噬细胞介导的骨免疫在种植体植入后骨整合中的作用及其机制研究[J]. 口腔医学研究, 2025, 41(3): 189-194.

LI Congcong, ZHAO Li. Role and Mechanisms of Macrophage-mediated Osteoimmunity in Osseointegration after Implant Placement[J]. Journal of Oral Science Research, 2025, 41(3): 189-194.

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