垂直距离升高和咬合丧失引起的下颌位置异常对成年大鼠髁突影响的影像学研究

doi:10.13701/j.cnki.kqyxyj.2025.03.004

口腔医学研究 ›› 2025, Vol. 41 ›› Issue (3): 195-199.DOI: 10.13701/j.cnki.kqyxyj.2025.03.004

垂直距离升高和咬合丧失引起的下颌位置异常对成年大鼠髁突影响的影像学研究

王悦^1,2, 耿威^3*

1.西安交通大学口腔医院陕西省颅颌面精准医学研究重点实验室陕西西安 710004;
2.西安交通大学口腔医院口腔修复科陕西西安 710004;
3.首都医科大学附属北京口腔医院种植科北京 100070

出版日期:2025-03-28 发布日期:2025-03-25
通讯作者: *耿威,E-mail:gengwei717@163.com
作者简介:王悦(1998~ ),女,山西临汾人,硕士,医师,研究方向:口腔修复。
基金资助:
国家自然科学基金面上项目(编号:62071313)

Imaging Study on Effect of Abnormal Mandibular Position Caused by Increased Vertical Dimension and Loss of Occlusion on Condyle of Adult Rats

WANG Yue^1,2, GENG Wei^3*

1. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China;
2. Department of Prosthodontics, College of Stomatology, Xi'an Jiaotong University, Xi'an 710004, China;
3. Department of Dental Implant Centre, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing 100070, China

Online:2025-03-28 Published:2025-03-25

摘要/Abstract

摘要： 目的: 研究不同下颌位置改变时,成年大鼠髁突前部及髁突后部在不同时间的影像学变化。方法: 本研究构建了对照组、垂直距离升高组及咬合丧失组3组动物模型,分别于实验1周、2周、4周及8周时在体式显微镜下观察大鼠髁突大体变化,并使用显微CT(mirco computed tomography, Mirco CT)分析大鼠髁突前部及后部软骨下骨形态学变化。结果: 与对照组相比,垂直距离升高组髁突前部骨形态学参数在早期无明显变化,8周时出现骨吸收,咬合丧失组在第2周时逐渐发生代偿;垂直距离升高组髁突后部软骨下骨在早期出现骨代偿,8周时与对照组相比无明显差异;咬合丧失组则在各个时间段均出现骨代偿。结论: 当垂直距离升高和咬合丧失时,大鼠髁突软骨下骨均发生骨改建,但两者的骨改建程度及部位不完全相同。

关键词: 髁突, 软骨下骨, 垂直距离, 咬合丧失

Abstract: Objective: To study the imaging changes of the anterior and posterior condyle at different time and mandibular positions. Methods: Three animal models, i.e.control group, increased vertical dimension group, and loss of occlusion group were constructed. The general changes of condylar process of rats were observed under stereomicroscope at 1 W, 2 W, 4 W, and 8 W respectively, and the subchondral morphological parameters of subchondral bone in the anterior and posterior parts of condylar process of rats were analyzed by Mirco CT. Results: Compared with the control group, there was no significant change in the subchondral morphological parameters of the anterior condylar bone in the increased vertical dimension group in the early stage, and bone resorption occurred at 8 W; however, bone was graduallycompensated since 2 W in the loss ofocclusion group.The condylar posterior subchondral bone in the increased vertical dimension group showed bone compensation in the early stage, and there was no significant difference compared with the control group at 8 W. In the loss of occlusion group, bone compensation occurred at all time periods. Conclusion: When the vertical distance increases or decreases, the subchondral bone of the rat condylar cartilage undergoes bone remodeling, but the degree and location of bone remodeling are not exactly the same.

Key words: condyle, subchondral bone, vertical distance, loss of occlusion

王悦, 耿威. 垂直距离升高和咬合丧失引起的下颌位置异常对成年大鼠髁突影响的影像学研究[J]. 口腔医学研究, 2025, 41(3): 195-199.

WANG Yue, GENG Wei. Imaging Study on Effect of Abnormal Mandibular Position Caused by Increased Vertical Dimension and Loss of Occlusion on Condyle of Adult Rats[J]. Journal of Oral Science Research, 2025, 41(3): 195-199.

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垂直距离升高和咬合丧失引起的下颌位置异常对成年大鼠髁突影响的影像学研究

Imaging Study on Effect of Abnormal Mandibular Position Caused by Increased Vertical Dimension and Loss of Occlusion on Condyle of Adult Rats

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