甲状旁腺激素相关蛋白在下颌骨髁突软骨生长发育中的作用机制

doi:10.13701/j.cnki.kqyxyj.2021.09.005

口腔医学研究 ›› 2021, Vol. 37 ›› Issue (9): 791-793.DOI: 10.13701/j.cnki.kqyxyj.2021.09.005

甲状旁腺激素相关蛋白在下颌骨髁突软骨生长发育中的作用机制

庄欠志, 武秀萍^*

山西医科大学口腔医学院·口腔医院,口腔疾病防治与新材料山西省重点实验室山西太原 030001

收稿日期:2020-06-28 出版日期:2021-09-28 发布日期:2021-09-16
通讯作者: *武秀萍,E-mail:77wxp@163.com
作者简介:庄欠志(1990~ ),男,山东潍坊人,硕士在读,研究方向:颞下颌关节、口腔正畸学。
基金资助:
山西省重点研发计划项目(编号:201803D31065)山西省回国留学人员科研资助项目(编号:HGKY2019055)

Mechanisms of Parathyroid Hormone Related Protein in Growth and Development of Mandibular Condylar Cartilage:A Review

ZHUANG Qianzhi, WU Xiuping^*

School and Hospital of Stomatology, Shanxi Medical University＆Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan 030001,China

Received:2020-06-28 Online:2021-09-28 Published:2021-09-16

摘要/Abstract

摘要： 下颌骨髁突软骨是一种继发性纤维性软骨,其生长发育的调控过程可能更加复杂。近十几年来,国内外才渐有针对髁突软骨生长发育研究的相关报道。甲状旁腺激素相关蛋白(parathyroid hormone related protein ,PTHrP)是软骨代谢的关键调控因子,广泛参与软骨生长改建、形态发生及软骨内成骨的过程。同四肢软骨类似,PTHrP在下颌骨髁突软骨生长发育过程中亦发挥关键作用。深入了解PTHrP信号及相关因子在髁突软骨发育过程中的调节机制,可进一步明确PTHrP对颞下颌关节生长发育的影响,这对临床诊疗有重要指导意义。本文就PTHrP在下颌骨髁突软骨生长发育过程中的作用机制作一综述。

关键词: 甲状旁腺激素相关蛋白, 颞下颌关节, 髁突软骨, 机制

Abstract: Mandibular condylar cartilage is a secondary fibrocartilage, the regulation of which may be more complex. Only in the last decade or so has there been a growing body of research on the growth and development of condylar cartilage, both in China and abroad. Parathyroid hormone related protein (PTHrP) is a key regulator of cartilage metabolism and is widely involved in the process of cartilage growth and remodeling, morphogenesis, and osteogenesis within the cartilage. Similar to limb cartilages, PTHrP plays a key role in the growth and development of mandibular condylar cartilage. Deeply understanding the regulatory mechanism of PTHrP signaling and related factors during the development of condylar cartilage can further clarify the effect of PTHrP on the growth and development of temporomandibular joint, which has important guiding significance for clinical diagnosis and treatment. This article reviews the mechanism of PTHrP in the growth and development of mandibular condylar cartilage.

Key words: parathyroid hormone related protein, temporomandibular joint, condylar cartilage, mechanism

庄欠志, 武秀萍. 甲状旁腺激素相关蛋白在下颌骨髁突软骨生长发育中的作用机制[J]. 口腔医学研究, 2021, 37(9): 791-793.

ZHUANG Qianzhi, WU Xiuping. Mechanisms of Parathyroid Hormone Related Protein in Growth and Development of Mandibular Condylar Cartilage:A Review[J]. Journal of Oral Science Research, 2021, 37(9): 791-793.

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甲状旁腺激素相关蛋白在下颌骨髁突软骨生长发育中的作用机制

Mechanisms of Parathyroid Hormone Related Protein in Growth and Development of Mandibular Condylar Cartilage:A Review

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