β-磷酸三钙骨免疫学特性的研究进展

doi:10.13701/j.cnki.kqyxyj.2021.09.004

口腔医学研究 ›› 2021, Vol. 37 ›› Issue (9): 787-790.DOI: 10.13701/j.cnki.kqyxyj.2021.09.004

β-磷酸三钙骨免疫学特性的研究进展

单宇华, 陈振琦^*

上海交通大学医学院附属第九人民医院·口腔医学院口腔正畸科,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所上海 200011

收稿日期:2020-04-08 出版日期:2021-09-28 发布日期:2021-09-16
通讯作者: *陈振琦,E-mail:orthochen@yeah.net
作者简介:单宇华(1996~ ),女,上海人,硕士在读,研究方向:生物材料在颌面骨缺损的应用及机制。

Research Progress on Osteoimmunology Properties of β-TCP

SHAN Yuhua, CHEN Zhenqi^*

Department of Orthodontics, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Disease; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China

Received:2020-04-08 Online:2021-09-28 Published:2021-09-16

摘要/Abstract

摘要： β-磷酸三钙(β-TCP)作为植骨材料具有优良的生物相容性和骨传导性,免疫反应在决定β-TCP体内转归中起着重要的作用,β-TCP作为异物被免疫系统识别,触发免疫细胞的不同行为模式,从而影响着新骨形成。了解β-TCP植入后诱导的免疫环境和成骨之间的影响,有助于诱导最佳的局部免疫环境,为最终骨整合提供成骨和破骨的最佳平衡,本文将对β-TCP在骨免疫学领域的研究作一综述。

关键词: β-磷酸三钙, 骨免疫学, 骨替代物, 骨再生

Abstract: β-tricalcium phosphate (β-TCP), as bone graft material, has excellent biocompatibility and osteoconductivity. Immune response plays an important role in determining the internal outcome of β-TCP. β-TCP, as a foreign body, is recognized by the immune system and triggers different behavior patterns of immune cells, thus affecting the formation of new bone. It is helpful to understand the influence of immune environment and osteogenesis induced by β-TCP. In order to explore the optimal immune environment that provides balance between osteogenesis and osteoclastogenesis for osseointegration, this paper reviews the research of β-TCP in the field of bone immunology.

Key words: β-tricalcium phosphate, osteoimmunology, bone substitute, bone regeneration

单宇华, 陈振琦. β-磷酸三钙骨免疫学特性的研究进展[J]. 口腔医学研究, 2021, 37(9): 787-790.

SHAN Yuhua, CHEN Zhenqi. Research Progress on Osteoimmunology Properties of β-TCP[J]. Journal of Oral Science Research, 2021, 37(9): 787-790.

参考文献

[1] Chen Z, Yuen J, Crawford R, et al. The effect of osteoimmunomodulation on the osteogenic effects of cobalt incorporated β-tricalciumphosphate [J]. Biomaterials, 2015, 61:126-138.
[2] 史秀娣,马红梅.口腔生物材料对机体巨噬细胞生物学行为影响研究进展[J].中国实用口腔科杂志,2016,9(12):756-760.
[3] Miron RJ, Bosshardt DD. OsteoMacs: Key players around bone biomaterials [J]. Biomaterials, 2016, 82:1-19.
[4] 李明政,肖宇,吴珍珍, 等.巨噬细胞在材料诱导成骨中作用的研究进展[J].口腔医学研究,2017,33(10):1123-1126.
[5] Grotenhuis N, VdToom HF, Kops N, et al. In vitro model to study the biomaterial-dependent reaction of macrophages in an inflammatory environment [J]. Br J Surg, 2014, 101(80):983-992.
[6] Chen Z, Klein T, Murray RZ, et al. Osteoimmunomodulation for the development of advanced bone biomaterials [J]. Materials Today, 2015, 19(6):304-321.
[7] Chen Z, Wu C, Gu W, et al. Osteogenic differentiation of bone marrow MSCs by β-tricalcium phosphate stimulating macrophages via BMP2 signallingpathway [J]. Biomaterials, 2014, 35(5):1507-1518.
[8] Guihard P, Danger Y, Brounais B, et al. Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on oncostatin M signaling [J]. Stem Cells, 2012, 30(4):762-772.
[9] Mokarram N, Bellamkonda RV. A perspective on immunomodulation and tissue repair [J]. Ann Biomed Eng, 2014, 42(2):338-351.
[10] Kucera T, Sponer P, Urban K, et al. Histological assessment of tissue from large human bone defects repaired with β-tricalciumphosphate [J]. Eur J Orthop Surg Traumatol, 2014, 24(8):1357-1365.
[11] Jensen SS, Bosshardt DD, Gruber R, et al. Long-term stability of contour augmentation in the esthetic zone: histologic and histomorphometric evaluation of 12 human biopsies 14 to 80 months after augmentation [J]. J Periodontol, 2014, 85(11):1549-1556.
[12] Croes M, ner FC, van Neerven D, et al. Proinflammatory T cells and IL-17 stimulate osteoblast differentiation [J]. Bone, 2016, 84:262-270.
[13] Weitzmann MN. Bone and the immune system [J]. Toxicol Pathol, 2017, 45(7):911-924.
[14] Lei H, Schmidt-Bleek K, Dienelt A, et al. Regulatory T cell-mediated anti-inflammatory effects promote successful tissue repair in both indirect and direct manners [J]. Front Pharmacol, 2015, 6:184.
[15] Kobayashi Y, Uehara S, Udagawa N, et al. Regulation of bone metabolism by Wntsignals [J]. J Biochem, 2016, 159(4):387-392.
[16] Majidinia M, Sadeghpour A, Yousefi B. The roles of signaling pathways in bone repair and regeneration [J]. J Cell Physiol, 2018, 233(4):2937-2948.
[17] Jia X, Xu H, Miron RJ, et al. EZH1 is associated with TCP-induced bone regeneration through macrophage polarization [J]. Stem Cells Int, 2018, 2018:6310560.
[18] Salazar VS, Gamer LW, Rosen V. BMP signalling in skeletal development, disease and repair [J]. Nat Rev Endocrinol, 2016, 12(4):203-221.
[19] Soltanoff CS, Yang S, Chen W, et al. Signaling networks that control the lineage commitment and differentiation of bone cells [J]. Crit Rev Eukaryot Gene Expr, 2009, 19(1):1-46.
[20] Boudrieau RJ, Mitchell SL, Seeherman H. Mandibular reconstruction of a partial hemimandibulectomy in a dog with severe malocclusion [J]. Vet Surg, 2004, 33(2):119-130.
[21] Bouler JM, Pilet P, Gauthier O, et al. Biphasic calcium phosphate ceramics for bone reconstruction: A review of biological response [J]. Acta Biomater, 2017, 53:1-12.
[22] Silva SN, Pereira MM, Goes AM, et al. Effect of biphasic calcium phosphate on human macrophage functions in vitro [J]. J Biomed Mater Res A, 2003, 65(4):475-481.
[23] Hayrapetyan A, Jansen JA, van den Beucken JJ. Signaling pathways involved in osteogenesis and their application for bone regenerative medicine [J]. Tissue Eng Part B Rev, 2015, 21(1):75-87.
[24] Gamblin AL, Brennan MA, Renaud A, et al. Bone tissue formation with human mesenchymal stem cells and biphasic calcium phosphate ceramics: the local implication of osteoclasts and macrophages [J]. Biomaterials, 2014, 35(36):9660-9667.
[25] Pajarinen J, Lin T, Gibon E, et al. Mesenchymal stem cell-macrophage crosstalk and bone healing [J]. Biomaterials, 2019, 196:80-89.
[26] Wang J, Tang J, Zhang P, et al. Surface modification of magnesium alloys developed for bioabsorbable orthopedic implants: a general review [J]. J Biomed Mater Res B Appl Biomater, 2012, 100(6):1691-1701.
[27] Chen Z, Mao X, Tan L, et al. Osteoimmunomodulatory properties of magnesium scaffolds coated with β-tricalciumphosphate [J]. Biomaterials, 2014, 35(30):8553-8565.
[28] Lai Y, Li Y, Cao H, et al. Osteogenic magnesium incorporated into PLGA/TCP porous scaffold by 3D printing for repairing challenging bone defect [J]. Biomaterials, 2019, 197:207-219.

β-磷酸三钙骨免疫学特性的研究进展

Research Progress on Osteoimmunology Properties of β-TCP

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	黄佳倩, 马国武. 他汀类药物在颌骨缺损再生中的骨代谢及免疫调控研究进展[J]. 口腔医学研究, 2021, 37(7): 592-594.
[2]	王鹏程, 陈春晖, 童熹, 傅新海. β-TCP植入与口腔修复膜覆盖治疗对颌骨囊肿术后骨缺损的修复效果分析[J]. 口腔医学研究, 2021, 37(3): 260-263.
[3]	程璐, 史剑杰. 骨膜减张技术在引导骨再生术中的应用研究进展[J]. 口腔医学研究, 2020, 36(9): 814-816.
[4]	乐柯, 董衡, 陈力, 杨光雯, 陈琳, 刘晖, 周娜, 牟永斌. 应用三维预成型钛网在上颌前牙区骨增量疗效的临床研究[J]. 口腔医学研究, 2020, 36(5): 481-485.
[5]	呙誉东, 周炼. 帐篷螺丝技术在上前牙区连续缺失种植修复中的疗效评价[J]. 口腔医学研究, 2020, 36(3): 298-301.
[6]	薛国平, 刘青梅. 低水平激光治疗应用于颌骨骨再生的研究进展[J]. 口腔医学研究, 2019, 35(9): 830-832.
[7]	陈瑞, 李风兰. 阿司匹林/富血小板纤维蛋白复合物促进大鼠种植体周围骨缺损修复的实验研究[J]. 口腔医学研究, 2019, 35(8): 761-765.
[8]	于文凤, 赵世俊, 吕敏敏, 崔凤林, 康梅珍, 张志媛. 浓缩生长因子在上颌前牙区引导骨再生术中的临床应用[J]. 口腔医学研究, 2019, 35(7): 676-680.
[9]	高筱萌,高海. 生物纳米材料在骨组织工程中的研究进展[J]. 口腔医学研究, 2019, 35(6): 524-526.
[10]	于婉琦, 杨诗卉, 周哲, 周延民, 赵静辉. 老年患者微创上颌窦底提升同期种植的临床研究[J]. 口腔医学研究, 2019, 35(3): 258-261.
[11]	郑钧元, 何俐, 胡图强, 王美钧. 铒激光治疗老年患者前磨牙牙周角型骨缺损的半年疗效观察1例[J]. 口腔医学研究, 2019, 35(3): 307-308.
[12]	梁婷婷, 郭吕华. 骨硬化蛋白抗体的临床研究进展[J]. 口腔医学研究, 2019, 35(12): 1119-1121.
[13]	季平, 杨生. 个性化钛网在口腔种植骨增量中的应用[J]. 口腔医学研究, 2019, 35(11): 1011-1015.
[14]	孙雨虹, 杨柳, 王硕, 夏露露, 郭瓅, 曹正国, 华先明. 牙周-正畸联合治疗上前牙重度牙周炎伴牙移位1例[J]. 口腔医学研究, 2019, 35(11): 1100-1102.
[15]	王超, 夏荣, 刘芮, 肖楠楠. 3D打印个性化钛网重建牙槽嵴骨缺损的实验研究[J]. 口腔医学研究, 2019, 35(1): 80-83.