口腔医学研究

口腔医学研究 ›› 2026, Vol. 42 ›› Issue (5): 433-438.DOI: 10.13701/j.cnki.kqyxyj.2026.05.012

• 口腔黏膜病学研究 • 上一篇    下一篇

α硫辛酸对灼口综合征患者唾液氧化应激及免疫指标的影响与药效学模型分析

王博, 徐小芳, 石佩佩, 张梅华*   

  1. 国药一机医院(内蒙古医科大学第四附属医院)牙周黏膜科 内蒙古 包头 014030
  • 收稿日期:2025-07-04 发布日期:2026-05-25
  • 通讯作者: *张梅华,E-mail:439657351@qq.com
  • 作者简介:王博(1998~ ),女,黑龙江大庆人,本科,医师,研究方向:口腔内科学。
  • 基金资助:
    2024年度国药北方科研基金项目(编号:GYBFGS2024011)

Influence of Alpha-lipoic Acid on Salivary Oxidative Stress and Immune Indicators in Patients with Burning Mouth Syndrome and Pharmacodynamic Model Analysis

WANG Bo, XU Xiaofang, SHI Peipei, ZHANG Meihua*   

  1. Department of Periodontal Mucosa, National Pharmaceutical First Machine Hospital (Fourth Affiliated Hospital of Inner Mongolia Medical University), Baotou 014030, China
  • Received:2025-07-04 Published:2026-05-25

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摘要： 目的:探讨α硫辛酸(alpha-lipoicacid,ALA)对灼口综合征(burning mouth syndrome,BMS)患者唾液氧化应激和免疫指标的影响,并对ALA治疗BMS的疗效特征进行模型化评价。方法:选择2023年10月~2024年7月本院收治的BMS患者104例作为研究对象,随机将患者分为ALA组(n=52)和对照组(n=52),ALA组患者采用硫辛酸胶囊治疗,对照组应用常规治疗(采用谷维素、维生素B2、维生素E进行治疗)。对比两组患者治疗前后视觉模拟评分(visual analogue scale,VAS)评分、唾液中氧化应激及体液免疫水平。采用非线性混合效应模型建立ALA治疗BMS时间进程的药效学模型。结果:治疗后两组患者唾液中丙二醛(malondialdehyde,MDA)、总抗氧化能力(total antioxidant capacity,TAC)、过氧化氢酶(catalase,CAT)、超氧化物歧化酶(superoxide dismutase,SOD)、分泌型免疫球蛋白A(secretory immunoglobulin A,sIgA)、免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白A(immunoglobulin A,IgA)及免疫球蛋白M(immunoglobulin M,IgM)水平均显著改善(P<0.001),且相较于对照组,ALA组患者唾液中氧化应激及体液免疫指标改善效果更佳(P<0.001)。治疗后两组患者疼痛症状均显著改善(P<0.001),且相较于对照组,ALA组患者VAS量表评分更低(P<0.001)。药效学模型分析发现,治疗前VAS与最大效应Emax参数存在显著相关性。模型Emax为5.83分,ET50为2.47周。协变量分析证实基线VAS对Emax具有正向调节作用,其校正因子为1.53(95%CI:1.72~2.14)。结论:ALA可有效改善BMS患者唾液氧化应激及免疫指标,ALA可有效降低BMS患者疼痛症状,其疗效优于常规治疗方法。

关键词: α硫辛酸, 灼口综合征, 氧化应激, 体液免疫, 非线性混合效应模型

Abstract: Objective: To investigate the effects of alpha lipoic acid (ALA) on salivary oxidative stress and immune indexes in patients with burning mouth syndrome (BMS), and to model and evaluate the therapeutic effect of ALA on BMS. Methods: A total of 104 BMS patients admitted to our hospital from October 2023 to July 2024 were selected and randomly divided into ALA group (n=52) and control group (n=52). Patients in the ALA group were treated with lipoic acid capsules, while patients in the control group were treated with conventional treatment. Visual analogue scale (VAS) scores, oxidative stress in saliva, and humoral immunity were compared between the two groups before and after treatment. A pharmacological model for the time course of ALA treatment of BMS using a nonlinear mixed effects model (NONMEM) was established. Results: After treatment, the levels of malondialdehyde (MDA), total antioxidant capacity (TAC), catalase (CAT), superoxide dismutase (SOD), secretory immunoglobulin A (sIgA), immunoglobulin G (IgG), immunoglobulin (IgA), and immunoglobulin M (IgM) in saliva of the two groups were significantly improved (P<0.001). Compared with the control group, the oxidative stress and humoral immunity indexes in saliva of the ALA group were better improved (P<0.001). After treatment, pain symptoms in both groups were significantly improved (P<0.001), and VAS scores in ALA group were lower than those in control group (P<0.001). The interaction effect of VAS score between the two groups was statistically significant (P<0.001). It was found that VAS score before medication had significant influence on model parameter Emax. The final model parameters were Emax 5.83 minutes and ET50 2.47 weeks. The correction factor of baseline value for parameter Emax was 1.53, that is, for every 1 point increase of baseline VAS, the Emax value would increase by 1.53 points. Conclusion: ALA can effectively improve the salivary oxidative stress and immune indexes of BMS patients, and ALA can effectively reduce the pain symptoms of BMS patients, and its curative effect is better than conventional treatment.

Key words: alpha-lipoic acid, burning mouth syndrome, oxidative stress, humoral immunity, nonlinear mixed effects modeling