引导组织再生生物膜应用于拔牙术后牙槽骨缺损修复的临床研究

doi:10.13701/j.cnki.kqyxyj.2017.07.023

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (7): 782-786.DOI: 10.13701/j.cnki.kqyxyj.2017.07.023

引导组织再生生物膜应用于拔牙术后牙槽骨缺损修复的临床研究

罗正文, 刘济远, 李佳, 潘剑^*

口腔疾病研究国家重点实验室,四川大学华西口腔医院口腔外科四川成都 610041

收稿日期:2017-01-14 出版日期:2017-07-20 发布日期:2017-07-27
通讯作者: 潘剑,电话:028-85501440
作者简介:罗正文(1990~ ),男,广东人,硕士在读,主要从事口腔颌面外科的临床治疗工作。

Clinical Trial of Guided Tissue Regeneration Membrane in Repairing Alveolar Bone Defect Secondary to Tooth Extraction.

LUO Zheng-wen, LIU Ji-yuan, LI Jia, PAN Jian^*.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Received:2017-01-14 Online:2017-07-20 Published:2017-07-27

摘要/Abstract

摘要： 目的:观察和评价引导组织再生生物膜应用于牙槽骨缺损修复的有效性和安全性。方法:采用随机、开放、平行、阳性对照(Bio-Gide可吸收生物膜)临床试验设计。主要评价指标为骨缺损部位的影像学检查,次要评价指标为:手术伤口愈合情况、排异反应、骨代谢变化、骨感染征象。安全性评价指标为不良反应发生率。结果:本临床试验共入组40例受试者,完成试验39例,脱落1例。主要有效性评价指标影像学检查有效率:试验组89.47％、对照组95.00％。次要疗效评价2组材料植入后伤口愈合时间均小于12 d,2组均无排异反应、无骨代谢变化、无骨感染征象。不良事件发生率试验组:5.00%,对照组:0.00%。结论:引导组织再生生物膜应用于拔牙术后牙槽骨缺损修复的疗效和安全性非劣效于Bio-Gide可吸收生物膜。

关键词: 拔牙, 牙槽骨缺损, 引导骨再生术, 引导组织再生膜, 临床试验

Abstract: Objective: To explore the efficacy and safety of suided tissue regeneration membrane (GTRM) in repairing alveolar bone defect secondary to tooth extraction. Methods: A randomized, open, parallel, positively controlled (Bio-gide) clinical trial was performed. The major index for evaluating efficacy was imaging examination. The secondary indexes for evaluating efficacy were surgical wound healing, rejection reaction, changes of bone metabolism, and bone infection signs. The incidence of adverse reaction was recorded for safety evaluation. Results: Forty cases were included and 39 cases completed the clinical trial. The effective rates of imaging examination in GTRM and Bio-gide group were 89.47% and 95%, respectively. The wound healing time of both groups was less than 12 days. No rejection reaction, bone metabolic change, and bone infection sign were observed. The incidences of adverse events in ADM group and Bio-gide group were 5.00% and 0.00%, respectively. Conclusion: No significant difference was found as to efficacy and safety in repairing bone defect secondary to tooth extraction between GTRM group and Bio-gide group.

Key words: Tooth extraction , Defect of alveolar bone, Guided bone regeneration, Guided tissue regeneration membrane, Clinical trial

中图分类号:

R782.1

罗正文, 刘济远, 李佳, 潘剑. 引导组织再生生物膜应用于拔牙术后牙槽骨缺损修复的临床研究[J]. 口腔医学研究, 2017, 33(7): 782-786.

LUO Zheng-wen, LIU Ji-yuan, LI Jia, PAN Jian.. Clinical Trial of Guided Tissue Regeneration Membrane in Repairing Alveolar Bone Defect Secondary to Tooth Extraction.[J]. Journal of Oral Science Research, 2017, 33(7): 782-786.

参考文献

[1] Zhang DZ, Xiao WL, Zhou R, et al. Evaluation of bone height and bone mineral density using cone beam computed tomography after secondary bone graft in alveolar cleft [J]. Journal of Craniofacial Surgery, 2015, 26(5)∶1463-1466
[2] Montero J, Mazzaglia G. Effect of Removing an Impacted Mandibular Third Molar on the Periodontal Status of the Mandibular Second Molar [J]. Journal of Oral & Maxillofacial Surgery Official Journal of the American Association of Oral & Maxillofacial Surgeons, 2011, 69(11)∶2691-2697
[3] 马士卿, 张旭, 孙迎春,等.引导骨组织再生膜的研究进展[J].口腔医学研究,2016,32(3)∶308-310
[4] 牟琳.Bio-gide膜与Bio-oss骨代材料在引导骨组织再生术中的应用[J].国际口腔科学杂志,2004(s1)∶156-158
[5] 胡开进, 杨擎天. 微创拔牙理念及技术操作[J].国际口腔科学杂志,2011,38(3)∶249-252
[6] Schropp L, Wenzel A, Kostopoulos L, et al. Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study [J]. International Journal of Periodontics & Restorative Dentistry, 2003, 23(4)∶313-323
[7] Tan W L, Wong T L, Wong M C, et al. A systematic review of post-extractional alveolar hard and soft tissue dimensional changes in humans [J]. Clinical Oral Implants Research, 2012, 23 Suppl 5(supplement)∶1-21
[8] Mardas N, Chadha V, Donos N. Alveolar ridge preservation with guided bone regeneration and a synthetic bone substitute or a bovine-derived xenograft: a randomized, controlled clinical trial [J]. Clinical Oral Implants Research, 2010, 21(7)∶688-698
[9] de Santana R B, de Mattos C M, Francischone C E, et al. Superficial topography and porosity of an absorbable barrier membrane impacts soft tissue response in guided bone regeneration [J]. Journal of Periodontology, 2010, 81(6)∶926-933

[1]	黄巧艳, 胡砚平. 下颌埋伏亲吻磨牙微创拔除1例[J]. 口腔医学研究, 2020, 36(9): 887-888.
[2]	胡涌昕, 张雨慧, 廖婷, 邹瑞, 周丽斌. 阻生齿拔除车针误吞1例[J]. 口腔医学研究, 2020, 36(7): 703-704.
[3]	朱李军, 李俊, 王书琴, 江穂, 王启朋, 冯航. 抗凝患者拔牙采用肝素桥接与维持抗凝两种方法的效果对比[J]. 口腔医学研究, 2020, 36(6): 554-557.
[4]	马璋玉, 张丛笑. 有抗菌能力的牙周引导组织再生膜的制备研究[J]. 口腔医学研究, 2020, 36(2): 126-130.
[5]	耿双双, 王健, 杨莉, 冯欣欣, 路立花. 位点保存对牙周病患者牙周状况影响的临床研究[J]. 口腔医学研究, 2020, 36(11): 1022-1026.
[6]	李娟, 张栋, 康壮飞, 张宁, 谷建琦. 阻生上颌第三磨牙拔除术后上颌第二磨牙远端的牙周变化[J]. 口腔医学研究, 2020, 36(11): 1027-1030.
[7]	王雪涛, 李璁, 李向春, 李芳凝. CBCT对下颌第三磨牙手术术式选择的影响作用[J]. 口腔医学研究, 2020, 36(1): 33-36.
[8]	乔星, 张士珑, 康文静, 刘春艳, 胡骁颖, 卢海燕. 骨性Ⅰ类高角拔牙后上气道变化的研究[J]. 口腔医学研究, 2019, 35(9): 858-862.
[9]	于文凤, 赵世俊, 吕敏敏, 崔凤林, 康梅珍, 张志媛. 浓缩生长因子在上颌前牙区引导骨再生术中的临床应用[J]. 口腔医学研究, 2019, 35(7): 676-680.
[10]	崔庆赢, 陈思宇, 付帅, 张长彬, 马文, 黎明. 鼻底入路拔除上颌中切牙区高位埋伏多生牙[J]. 口腔医学研究, 2019, 35(7): 686-689.
[11]	张玺,王翔,王林,谷妍,吴可,赵春洋. 前牙深覆盖伴单颗下中切牙先天缺失患者不同拔牙模式疗效的研究[J]. 口腔医学研究, 2018, 34(9): 956-959.
[12]	文珊辉,黄兰柱,林梓桐,韩超,王铁梅. CBCT对不同年龄组间下颌第三磨牙拔除风险的评估[J]. 口腔医学研究, 2017, 33(5): 516-519.
[13]	张建云,李贵凤,胡小蓓,雷浪. Tip-Edge Plus与Damon托槽对拔牙病例前牙转矩控制的比较[J]. 口腔医学研究, 2017, 33(5): 546-549.
[14]	李向军,张晓燕,张晓,刘宇,张旭东. 2种微动力系统应用于下颌低位阻生智齿拔除术的比较研究[J]. 口腔医学研究, 2017, 33(5): 554-558.
[15]	张雨，林赳，高巍，胡懿，高一，熊文碧，潘剑. 大豆苷元对骨质疏松模型大鼠拔牙后牙槽窝骨修复的影响[J]. 口腔医学研究, 2017, 33(3): 258-261.

引导组织再生生物膜应用于拔牙术后牙槽骨缺损修复的临床研究

Clinical Trial of Guided Tissue Regeneration Membrane in Repairing Alveolar Bone Defect Secondary to Tooth Extraction.

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics