脂肪干细胞成骨分化机制的研究进展

doi:10.13701/j.cnki.kqyxyj.2019.10.002

口腔医学研究 ›› 2019, Vol. 35 ›› Issue (10): 919-921.DOI: 10.13701/j.cnki.kqyxyj.2019.10.002

脂肪干细胞成骨分化机制的研究进展

刘向东, 宋应亮^*

军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔生物工程技术研究中心,第四军医大学口腔医院种植科陕西西安 710032

收稿日期:2018-11-13 出版日期:2019-10-28 发布日期:2019-10-22
通讯作者: 宋应亮,E-mail:songyingliang@163.com
作者简介:刘向东(1990~ ), 男,河北邯郸人,硕士在读,主要从事口腔种植研究。
基金资助:
国家自然科学基金 (编号:81771107、81470775)

Research Progress in Osteogenic Differentiation Mechanism of Adipose-derived Stem Cells.

LIU Xiangdong, SONG Yingliang^*

State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Implant Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.

Received:2018-11-13 Online:2019-10-28 Published:2019-10-22

摘要/Abstract

摘要： 提高种植体骨结合,尤其是糖尿病患者的种植体骨结合是口腔种植医生正在面对且亟待解决的难题之一,脂肪干细胞为解决上述问题提供了新的思路,然而脂肪干细胞的成骨分化能力有待提高。本文总结促进脂肪干细胞成骨分化的有效手段以及具体机制,重点综述微小RNA (microRNA,miRNA)以及脑信号蛋白3a (Semaphorin3A ,Sema3a)对脂肪干细胞成骨分化的影响及机制,并对未来研究进行展望。

关键词: 脂肪干细胞, 微小RNA, 脑信号蛋白3a

Abstract: Increasing implant osseointegration, especially for diabetic patients, is one of the problems that every oral implant doctor is facing. Adipose derived stem cells (ASCs) provide new ideas for solving above problems. However,its osteogenesis needs improving. This article mainly summarizes the effective methods of osteogenic differentiation of ASCs and its specific mechanism. The focus is on microRNA, Semaphorin3A and these possible mechanisms. Lastly, we look forward to future research findings.

Key words: adipose-derived stem cells, microRNA, Semaphorin3A

刘向东, 宋应亮. 脂肪干细胞成骨分化机制的研究进展[J]. 口腔医学研究, 2019, 35(10): 919-921.

LIU Xiangdong, SONG Yingliang. Research Progress in Osteogenic Differentiation Mechanism of Adipose-derived Stem Cells.[J]. Journal of Oral Science Research, 2019, 35(10): 919-921.

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脂肪干细胞成骨分化机制的研究进展

Research Progress in Osteogenic Differentiation Mechanism of Adipose-derived Stem Cells.

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