医用β钛合金的性能研究现状

doi:10.13701/j.cnki.kqyxyj.2020.06.001

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (6): 501-508.DOI: 10.13701/j.cnki.kqyxyj.2020.06.001

• 特约述评 • 下一篇

医用β钛合金的性能研究现状

刘建国^1,2,3*, 周宏博¹

1.遵义医科大学口腔医学院贵州遵义 563099;
2.贵州省普通高等学校口腔疾病研究特色重点实验室贵州遵义 563006;
3.遵义市口腔疾病研究重点实验室贵州遵义 563006

收稿日期:2020-05-30 出版日期:2020-07-03 发布日期:2020-07-06
通讯作者: ^*刘建国,E-mail: 13087891001@163. com
作者简介:刘建国,教授,主任医师,专业技术二级,博士,上海交通大学、苏州大学兼职博士研究生导师。遵义医科大学党委副书记、校长,贵州省高等学校重点学科口腔医学学科带头人。教育部口腔医学教学指导委员会成员,中华口腔医学会牙体牙髓病学专业委员会常务委员,中华医学会医学科研管理分会委员,贵州省口腔医学会名誉会长。主持或参与国家级科研项目8项,省部级重点项目9项,参编专著与教材4部,发表论文280余篇,申报专利15件,获得授权专利9件,培养研究生78人。获省级科技进步奖一等奖、二等奖、三等奖各1项,贵州省青年科技奖1项,市厅级科技进步奖9项,省级教学成果奖1项。是国务院特殊津贴专家、贵州省省管专家,省五一劳动奖章、五四青年奖章、优秀科技工作者、教学名师和优秀硕士研究生导师等20余个荣誉称号获得者。现为《遵义医科大学学报》主编,《口腔医学研究》副主编,《上海口腔医学》《牙体牙髓牙周病学杂志》等10余家专业期刊编委。
基金资助:
贵州省委组织部第六批人才基地《贵州省医用生物材料研发人才基地》(RCJD2018-9);贵州省教育厅青年科技人才成长项目(黔教合KY字[2016]207);遵义市委组织部首批人才基地《医用生物材料研发人才基地》(遵委[2019]69号)

Development of β-type Medical Titanium Alloys’ Performance

LIU Jianguo^1,2,3*, ZHOU Hongbo¹

1. School of Stomatology, Zunyi Medical University, Zunyi 563099, China;
2. Key Laboratory of Oral Disease Research, Guizhou Institution of Higher Education, Zunyi 63006, China;
3. Key Laboratory of Oral Disease Research of Zunyi City, Zunyi 563006, China

Received:2020-05-30 Online:2020-07-03 Published:2020-07-06

摘要/Abstract

摘要： 与传统医用α钛合金相比,医用β钛合金因其无生物毒性、良好的生物相容性、优异的耐生物腐蚀降解性能,以及与人体骨组织接近的力学性能等,在种植体材料、颌面骨修复植入材料等领域得到广泛关注。本文从医用β钛合金的制备及加工工艺技术、性能特点以及尚待研究的性能等方面,介绍医用β钛合金在口腔医学领域的应用展望。

关键词: 医用β钛合金, 口腔种植, 生物相容性, 弹性模量, 耐腐蚀性

Abstract: Compared with traditional α-type medical titanium alloy, β-type medical titanium alloys have been widely applied as implants and maxillofacial bone repairing implants because of their no biotoxicity, good biocompatibility, excellent degradable behavior, and mechanical properties close to the human natural bone. The present paper summarized the development of β-type medical titanium alloys applied in stomatology based on their preparation and deformation technology, mechanical properties, corrosion resistance, biocompatibility, and so on.

Key words: β-type medical titanium alloys, oral implants, biocompatibility, young’s modulus, corrosion resistance

刘建国, 周宏博. 医用β钛合金的性能研究现状[J]. 口腔医学研究, 2020, 36(6): 501-508.

LIU Jianguo, ZHOU Hongbo. Development of β-type Medical Titanium Alloys’ Performance[J]. Journal of Oral Science Research, 2020, 36(6): 501-508.

参考文献

[1] 于婉琦,周延民,赵静辉.口腔种植体新材料的研究现状[J].国际口腔医学杂志,2019,46(4): 488-496.
[2] 魏芬绒,王海,金旭丹,等.生物医用钛合金材料及其应用 [J].世界有色金属,2018,494(2): 271-273.
[3] 张文毓.低弹性模量钛合金的研究与应用 [J].船舶物资与市场,2019,(12): 11-16.
[4] Leyens C, Peters M. Titanium and titanium alloys: fundamentals and applications [M]. Weinheim: Wiley-VCH, 2003: 4.
[5] Banerjee D, Williams JC. Perspectives on titanium science and technology [J]. Acta Materialia, 2013, 61(3): 844-879.
[6] Li P, Jia Y, Wang Y, et al. Effect of Fe addition on microstructure and mechanical properties of as-cast Ti49Ni51 alloy [J]. Materials (Basel), 2019, 12(19): 3114.
[7] Im YD, Lee YK. Effects of Mo concentration on recrystallization texture, deformation mechanism and mechanical properties of Ti-Mo binary alloys [J]. J Alloy Compd, 2019, 821: 153508.
[8] 赵丹妹.由EBM和SLM制备的钛合金材料的安全性能评价[D]. 中国食品药品检定研究院, 2017.
[9] Weinmann M, Schnitter C, Stenzel M, et al. Development of bio-compatible refractory Ti/Nb(/Ta) alloys for application in patient-specific orthopaedic implants [J]. Int J Refract Metals Hard Mater, 2018, 75: 126-136.
[10] 刘欣,张卫平.基于电子束熔融技术的椎间融合器金属骨小梁结构单元的研究[J]. 生命科学仪器, 2014, 12(6): 16-20.
[11] Surmeneva MA, Koptyug A, Khrapov D, et al. In situ synthesis of a binary Ti-10at% Nb alloy by electron beam melting using a mixture of elemental niobium and titanium powders [J]. Journal of Materials Processing Technology, 2020, 282: 116646.
[12] Rabadia C, Liu Y, Cao GH, et al. High-strength β stabilized Ti-Nb-Fe-Cr alloys with large plasticity [J]. Mater Sci Eng A Struct Mater, 2018, 732: 368-377.
[13] Yemisci I, Mutlu O, Gulsoy N, et al. Experimentation and analysis of powder injection molded Ti10Nb10Zr alloy: a promising candidate for electrochemical and biomedical application [J]. Journal of Materials Research and Technology, 2019, 8(6): 5233-5245.
[14] Zhang YS, Hu JJ, Zhang W, et al. Discontinuous core-shell structured Ti-25Nb-3Mo-3Zr-2Sn alloy with high strength and good plasticity [J]. Materials Characterization, 2019, 147: 127-130.
[15] Zhang L, Tan J, He Z, et al. Effect of calcium pyrophosphate on microstructural evolution and in vitro biocompatibility of Ti-35Nb-7Zr composite by spark plasma sintering [J]. Mater Sci Eng C Mater Biol Appl, 2018, 90: 8-15.
[16] 戴世娟,朱运田,陈锋.新型医用β钛合金研究的发展现状及加工方法 [J]. 重庆理工大学学报(自然科学), 2016, 30(4): 27-34.
[17] Kuczyńska-Zemła D, Kijeńska-Gawrońska E, Chlanda A, et al. Biological properties of a novel β-Ti alloy with a low young’s modulus subjected to cold rolling [J]. Appl Surf Sci, 2020, 511: 145523.
[18] 孙润根,张德闯,林建国.高压固溶处理对β钛合金微观结构与弹性模量的影响 [J]. 湘潭大学自然科学学报, 2018, 40(4): 7-10.
[19] Ozan S, Lin J, Li Y, et al. Deformation mechanism and mechanical properties of a thermomechanically processed β Ti-28Nb-35.4Zr alloy [J]. J Mech Behav Biomed Mater, 2018, 78: 224-234.
[20] 许艳飞,文璟,肖逸锋,等.双级时效对Ti-25Nb-10Ta-1Zr-0.2Fe医用β钛合金显微组织与力学性能的影响 [J]. 中国有色金属学报, 2016, 26(9): 1912-1918.
[21] Kyong MK, Hee YK, Shuichi M. Effect of Zr content on phase stability, deformation behavior, and Young's modulus in Ti-Nb-Zr alloys [J]. Materials, 2020, 13(2): 476.
[22] Chen S, Wu J, Tu J, et al. Enhanced plasticity in a Ti-Ni-Nb-Zr shape memory bulk metallic glass composite with high Nb addition [J]. Mater Sci Eng A Struct Mater, 2017, 704: 192-198.
[23] Jiang B, Wang Q, Wen D, et al. Effects of Nb and Zr on structural stabilities of Ti-Mo-Sn-based alloys with low modulus [J]. Mater Sci Eng A Struct Mater, 2017, 687: 1-7.
[24] Shiraishi T, Yubuta K, Shishido T, et al. Elastic properties of as-solidified Ti-Zr binary alloys for biomedical applications [J]. Materials Transactions, 2016, 57(12): 1986-1992.
[25] Yang K, Wang J, Tang H, et al. Additive manufacturing of in-situ reinforced Ti-35Nb-5Ta-7Zr (TNTZ) alloy by selective electron beam melting (SEBM) [J]. J Alloys Compd, 2020, 826: 154178.
[26] 郭顺,郑琦,张俊松,等.低弹性模量亚稳β型Ti-38Nb合金的微观组织与力学行为 [J].稀有金属,2015,39(9): 769-774.
[27] 沈睿,陈锋,余新泉,等.氧含量对Ti-35Nb-3.7Zr-1.3Mo-xO合金组织与力学性能的影响 [J].东南大学学报:自然科学版,2015,45(3): 478-483.
[28] Nunes AR, Borborema S, Araújo LS, et al. Influence of thermo-mechanical processing on structure and mechanical properties of a new metastable β Ti-29Nb-2Mo-6Zr alloy with low Young’s modulus [J]. J Alloys Compd, 2020, 820: 153078.
[29] Lee T, Lee S, Kim I, et al. Breaking the limit of Young’s modulus in low-cost Ti-Nb-Zr alloy for biomedical implant applications [J]. J Alloys Compd, 2020, 828: 154401.
[30] Fojt J, Joska L, Malek J, et al. Corrosion behavior of Ti-39Nb alloy for dentistry [J]. Mater Sci Eng C Mater Biol Appl, 2015, 56: 532-537.
[31] Jawed SF, Rabadia CD, Liu Y, et al. Strengthening mechanism and corrosion resistance of beta-type Ti-Nb-Zr-Mn alloys [J]. Mater Sci Eng C Mater Biol Appl, 2020, 110: 110728.
[32] Kumar GL, Chinara S, Das S, et al. Studies on Ti-29Nb-13Ta-4.6Zr alloy for use as a prospective biomaterial [J]. Materials Today: Proceedings, 2019, 15: 11-20.
[33] 温科,李风兰.近β钛合金TLM表面双层辉光等离子渗氮及其腐蚀性能研究 [J]. 真空科学与技术学报, 2016, 36(2): 193-198.
[34] Raducanu D, Vasilescu E, Cojocaru VD, et al. Mechanical and corrosion resistance of a new nanostructured Ti-Zr-Ta-Nb alloy [J]. J Mech Behav Biomed Mater, 2011, 4(7): 1421-1430.
[35] Gill P, Munroe N, Pulletikurthi C, et al. Effect of manufacturing process on the biocompatibility and mechanical properties of Ti-30Ta alloy [J]. J Mater Eng Perform, 2011, 20(4): 819-823.
[36] Zhang Y, Chu K, He S, et al. Fabrication of high strength, antibacterial and biocompatible Ti-5Mo-5Ag alloy for medical and surgical implant applications [J]. Mater Sci Eng C Mater Biol Appl, 2020, 106: 110165.
[37] De Andrade DP, De Vasconcellos LM, Carvalho IC, et al. Titanium-35niobium alloy as a potential material for biomedical implants: In vitro study [J]. Mater Sci Eng C Mater Biol Appl, 2015, 56: 538-544.
[38] 段永刚,丁英奇,张龙,等.新型β钛合金Ti35Nb3Zr2Ta在人工关节假体应用中的生物相容性 [J].中国组织工程研究,2015,19(34): 5536-5540.
[39] 孙钰.新型低弹性模量钛合金TiNbZrTaSi生物相容性及骨整合能力实验研究[D].吉林大学, 2016.
[40] Meng X, Wang X, Guo Y, et al. Biocompatibility evaluation of a newly developed Ti-Nb-Zr-Ta-Si alloy implant [J]. J Biomater Tissue Eng, 2016, 6(11): 861-869.
[41] Zhang Y, Guo T, Li Q, et al. Novel ultrafine-grained β-type Ti-28Nb-2Zr-8Sn alloy for biomedical applications [J]. J Biomed Mater Res A, 2019, 107(8): 1628-1639.
[42] Wang Y, Wen C, Hodgson P, et al. Biocompatibility of TiO₂ nanotubes with different topographies [J]. J Biomed Mater Res A, 2014, 102(3): 743-751.
[43] Qadir MB, Lin J, Biesiekierski A, et al. Effect of anodized TiO₂-Nb₂O₅-ZrO₂ nanotubes with different nanoscale dimensions on the biocompatibility of a Ti35Zr28Nb alloy [J]. ACS Appl Mater Interfaces, 2020, 12(5): 6776-6787.
[44] Hu J, Zhong X, Fu X. Enhanced bone remodeling effects of low-modulus Ti-5Zr-3Sn-5Mo-25Nb alloy implanted in the mandible of beagle dogs under delayed loading[J]. ACS Omega, 2019, 4(20): 18653-18662.
[45] Lario J, Amigo A, Segovia F, et al. Surface modification of Ti-35Nb-10Ta-1.5Fe by the double acid-etching process [J]. Materials (Basel), 2018, 11(4): 494.
[46] Gu H, Ding Z, Yang Z, et al. Microstructure evolution and electrochemical properties of TiO₂/Ti-35Nb-2Ta-3Zr micro/nano-composites fabricated by friction stir processing [J]. Mater Des, 2019, 169: 107680.
[47] Wu H, Xie L, He M, et al. A wear-resistant TiO nanoceramic coating on titanium implants for visible-light photocatalytic removal of organic residues [J]. Acta Biomater, 2019, 97: 597-607.
[48] Kheradmandfard M, Kashani-Bozorg SF, Lee JS, et al. Significant improvement in cell adhesion and wear resistance of biomedical β-type titanium alloy through ultrasonic nanocrystal surface modification [J]. J Alloys Compd, 2018, 762: 941-949.

医用β钛合金的性能研究现状

Development of β-type Medical Titanium Alloys’ Performance

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	马国武, 贾崇智. 自体牙骨移植材料在口腔种植领域中的应用[J]. 口腔医学研究, 2020, 36(8): 709-712.
[2]	苏涛, 王星星, 向彪, 吴刚, 邹敏. 不同刚度的无托槽隐形矫治器扩大上颌牙弓的有限元分析[J]. 口腔医学研究, 2020, 36(5): 454-458.
[3]	丁美丽, 秦满, 郑佳佳, 张红梅, 林碧琛, 陈小贤. 新型生物陶瓷材料用于年轻恒牙牙髓切断术的效果评价[J]. 口腔医学研究, 2018, 34(7): 766-770.
[4]	张丽丽, 王远勤, 李镭. 同期永久基台影响种植体周围组织变化的随机对照研究[J]. 口腔医学研究, 2018, 34(5): 522-526.
[5]	赵萤, 陈慧, 张旻. 流体静压力对BMSCs/PRF复合构建的组织工程软骨移植物力学性能的影响[J]. 口腔医学研究, 2018, 34(3): 249-253.
[6]	刘艳丽. 口腔种植修复中附着龈重建的回顾性分析[J]. 口腔医学研究, 2018, 34(10): 1102-1104.
[7]	孙云, 王静. 微创环切术对种植修复效果影响的研究[J]. 口腔医学研究, 2017, 33(6): 671-674.
[8]	王倩倩，陈中中，杨亚茹，张建飞，张朋. 基于FEA的种植体个性化选择及力学性能评价[J]. 口腔医学研究, 2017, 33(3): 307-310.
[9]	李德超 ,何梦乔 ,李慕勤 ,郭晓娟 ,孟祥才. 纯钛微弧氧化-壳聚糖-海藻酸钠涂层的细胞相容性研究[J]. 口腔医学研究, 2016, 32(6): 559-563.
[10]	王怡丹,欧洪波,李婷燕,李帮辉,何吉琼. 种植牙术后全身与局部用药对PCT、CRP的影响及治疗效果研究[J]. 口腔医学研究, 2016, 32(4): 388-390.
[11]	周立伟,陈向深,乔永刚,张美超,魏世成. 纳米羟基磷灰石/聚醚醚酮复合种植体受力的三维有限元分析[J]. 口腔医学研究, 2016, 32(4): 391-394.
[12]	张岩,杨丽丽,张志勇,徐杰. 不同时期口腔种植修复患者血清CRP与尿脱氧吡啶啉含量变化与相关性[J]. 口腔医学研究, 2016, 32(4): 412-415.
[13]	盖立婷,徐高祥,张鲁鲁,高翔,姜秋. 聚乳酸/羟基磷灰石(PLLA/HA)复合物预成乳前牙根管桩的生物相容性研究[J]. 口腔医学研究, 2015, 31(11): 1073-1077.
[14]	李雅静,谢伟丽,刘滋川,孙亚杰,郭彬,陈兰竹,刘一志. β-SiC纳米线增强POSS复合树脂的力学性能研究[J]. 口腔医学研究, 2015, 31(10): 981-983.
[15]	杨磊,张力,张勇,丹金学. 口腔种植手术对绝经期骨质缺乏患者血清BGP、AKP和唾液钙、磷元素的影响[J]. 口腔医学研究, 2015, 31(10): 1004-1007.