季铵盐DMADDM抗菌改性牙科材料的研究进展

doi:10.13701/j.cnki.kqyxyj.2022.05.002

口腔医学研究 ›› 2022, Vol. 38 ›› Issue (5): 396-399.DOI: 10.13701/j.cnki.kqyxyj.2022.05.002

季铵盐DMADDM抗菌改性牙科材料的研究进展

封雪, 程磊^*

口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓病科四川成都 610041

收稿日期:2021-03-02 出版日期:2022-05-28 发布日期:2022-05-20
通讯作者: *程磊,E-mail: chengleidentist@163.com
作者简介:封雪(1996~ ),女,湖南衡阳人,硕士在读,住院医师,研究方向:龋病防治。
基金资助:
国家自然科学基金(编号:81870759)

Research Progress on Quaternary Ammonium Monomer Dimethylaminododecyl Methacrylate-modified Dental Materials

FENG Xue, CHENG Lei^*

Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu 610041, China

Received:2021-03-02 Online:2022-05-28 Published:2022-05-20

摘要/Abstract

摘要： 口腔微生物导致的口腔微生态失衡,可诱发多种口腔感染性疾病:如龋病、牙周病、口腔念珠菌病、种植体周围炎等。因此,牙科材料的抗菌改性有利于口腔菌斑性疾病的防治。甲基丙烯酸十二烷基二甲铵(dimethylaminododecyl methacrylate,DMADDM)是一种季铵盐型抗菌单体,具有广谱抗菌活性。其结构中的甲基丙烯酰基团能够通过聚合反应和材料基质交联,形成非释放型长效抗菌材料。本文将对近年来DMADDM改性牙科材料的抗菌作用、抗菌机制和耐药性研究等方面作一综述。

关键词: 甲基丙烯酸十二烷基二甲铵, 季铵盐, 抗菌材料, 耐药菌

Abstract: The ecological unbalance between oral microbes and host may induce infectious diseases, such as dental caries, periodontal diseases, candidiasis, peri-implantitis, and so on. Therefore, it is beneficial for dental materials with antimicrobial properties to prevent these illnesses. Dimethylaminododecyl methacrylate (DMADDM), a kind of quaternary ammonium salts, presents wide and remarkable antibacterial properties and is able to crosslink with substrate materials. DMADDM-modified dental materials can function as a non-releasing and long-lasting antibiotics. This paper reviews the antibiotic properties, antibacterial mechanism, and study of bacterial resistance of DMADDM-modified dental materials in recent years

Key words: dimethylaminododecyl methacrylate, quaternary ammonium salt, antibacterial material, drug-resistance bacteria

封雪, 程磊. 季铵盐DMADDM抗菌改性牙科材料的研究进展[J]. 口腔医学研究, 2022, 38(5): 396-399.

FENG Xue, CHENG Lei. Research Progress on Quaternary Ammonium Monomer Dimethylaminododecyl Methacrylate-modified Dental Materials[J]. Journal of Oral Science Research, 2022, 38(5): 396-399.

参考文献

[1] Kilian M, Chapple IL, Hannig M, et al. The oral microbiome-an update for oral healthcare professionals [J]. Br Dent J, 2016, 221(10): 657-666.
[2] Wang Z, Shen Y, Haapasalo M. Dental materials with antibiofilm properties [J]. Dent Mater, 2014, 30(2): e1-e16.
[3] Imazato S, Torii M, Tsuchitani Y, et al. Incorporation of bacterial into resin composite [J]. J Dent Res, 1994, 73(8):1437-1443.
[4] Imazato S, Kohno T, Tsuboi R, et al. Cutting-edge filler technologies to release bio-active components for restorative and preventive dentistry [J]. Dent Mater J, 2020, 39(1): 69-79.
[5] Han Q, Li B, Zhou X, et al. Anti-caries effects of dental adhesives containing quaternary ammonium methacrylates with different chain lengths [J]. Materials (Basel), 2017, 10(6):643.
[6] Makvandi P, Jamaledin R, Jabbari M, et al. Antibacterial quaternary ammonium compounds in dental materials: A systematic review [J]. Dent Mater, 2018, 34(6): 851-867.
[7] Jiao Y, Tay FR, Niu LN, et al. Advancing antimicrobial strategies for managing oral biofilm infections [J]. Int J Oral Sci, 2019, 11(3): 28.
[8] Wessels S, Ingmer H. Modes of action of three disinfectant active substances: A review [J]. Regul Toxicol Pharmacol, 2013, 67(3): 456-467.
[9] Murata H, Koepsel RR, Matyjaszewski K, et al. Permanent, non-leaching antibacterial surface--2: How high density cationic surfaces kill bacterial cells [J]. Biomaterials, 2007, 28(32): 4870-4879.
[10] Chen H, Zhou Y, Zhou X, et al. Dimethylaminododecyl methacrylate inhibits candida albicans and oropharyngeal candidiasis in a ph-dependent manner [J]. Appl Microbiol Biotechnol, 2020, 104(8):3585-3595.
[11] 陈智,陈瑞甜.龋病再认识[J].口腔医学研究,2020,36(1):1-6.
[12] Maia AC, Mangabeira A, Vieira R, et al. Experimental composites containing quaternary ammonium methacrylates reduce demineralization at enamel-restoration margins after cariogenic challenge [J]. Dent Mater, 2019, 35(8): e175-e183.
[13] Spencer P, Ye Q, Park J, et al. Adhesive/dentin interface: The weak link in the composite restoration [J]. Ann Biomed Eng, 2010, 38(6): 1989-2003.
[14] Chen C, Cheng L, Weir MD, et al. Primer containing dimethylaminododecyl methacrylate kills bacteria impregnated in human dentin blocks [J]. Int J Oral Sci, 2016, 8(4): 239-245.
[15] Ge Y, Ren B, Zhou X, et al. Novel dental adhesive with biofilm-regulating and remineralization capabilities [J]. Materials (Basel), 2017, 10(1):26.
[16] Wu TM, Li BL, Zhou X, et al. Evaluation of novel anticaries adhesive in a secondary caries animal model [J]. Caries Res, 2018, 52(1-2): 14-21.
[17] Cury JA, de Oliveira BH, dos Santos AP, et al. Are fluoride releasing dental materials clinically effective on caries control? [J]. Dent Mater, 2016, 32(3): 323-333.
[18] Wang SP, Ge Y, Zhou XD, et al. Effect of anti-biofilm glass-ionomer cement on streptococcus mutans biofilms [J]. Int J Oral Sci, 2016, 8(2): 76-83.
[19] Feng J, Cheng L, Zhou X, et al. Effects of water aging on the mechanical and anti-biofilm properties of glass-ionomer cement containing dimethylaminododecyl methacrylate [J]. Dent Mater, 2019, 35(3): 434-443.
[20] Siqueira JF Jr, Rôças IN. Clinical implications and microbiology of bacterial persistence after treatment procedures [J]. J Endod, 2008, 34(11): 1291-1301.e3.
[21] Liu D, Peng X, Wang SP, et al. A novel antibacterial resin-based root canal sealer modified by dimethylaminododecyl methacrylate [J]. Sci Rep, 2019, 9(1): 10632.
[22] Kumar Tiwari S, Guo X, Huang Y, et al. The inhibitory effect of quaternary ammonium salt on bacteria in root canal [J]. Sci Rep, 2019, 9(1): 12463.
[23] Tiwari SK, Wang S, Huang Y, et al. The antibacterial effects of quaternary ammonium salts in the simulated presence of inhibitors in root canals: A preliminary in-vitro study [J]. Coatings, 2020, 10(2):181.
[24] Busscher HJ, Rinastiti M, Siswomihardjo W, et al. Biofilm formation on dental restorative and implant materials [J]. J Dent Res, 2010, 89(7): 657-665.
[25] Bilhan H, Sulun T, Erkose G, et al. The role of candida albicans hyphae and lactobacillus in denture-related stomatitis [J]. Clin Oral Investig, 2009, 13(4): 363-368.
[26] Chen H, Han Q, Zhou X, et al. Heat-polymerized resin containing dimethylaminododecyl methacrylate inhibits candida albicans biofilm [J]. Materials (Basel), 2017, 10(4):431.
[27] Zhang KK, Ren B, Zhou X, et al. Effect of antimicrobial denture base resin on multi-species biofilm formation [J]. Int J Mol Sci, 2016, 17(7):1033.
[28] 李洁,马朝阳,金露,等.钛表面接枝大分子季铵盐抗菌性的研究[J].口腔医学研究,2017,33(8): 845-848.
[29] Li BL, Ge Y, Wu Y, et al. Anti-bacterial and microecosystem-regulating effects of dental implant coated with dimethylaminododecyl methacrylate [J]. Molecules, 2017, 22(11):2013.
[30] Zhou W, Peng X, Ma Y, et al. Two-staged time-dependent materials for the prevention of implant-related infections [J]. Acta Biomater, 2020, 101: 128-140.
[31] Wang S, Wang H, Ren B, et al. Drug resistance of oral bacteria to new antibacterial dental monomer dimethylaminohexadecyl methacrylate [J]. Sci Rep, 2018, 8(1):5509.
[32] Jiang YL, Qiu W, Zhou XD, et al. Quaternary ammonium-induced multidrug tolerant streptococcus mutans persisters elevate cariogenic virulence in vitro [J]. Int J Oral Sci, 2017, 9(12):e7.
[32] Lu J, Cheng L, Huang Y, et al. Resumptive streptococcus mutans persisters induced from dimethylaminododecyl methacrylate elevated the cariogenic virulence by up-regulating the quorum-sensing and vicrk pathway genes [J]. Front Microbiol, 2020, 10: 3102.

季铵盐DMADDM抗菌改性牙科材料的研究进展

Research Progress on Quaternary Ammonium Monomer Dimethylaminododecyl Methacrylate-modified Dental Materials

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