龈沟液内正畸牙移动相关生物标志物的研究进展

doi:10.13701/j.cnki.kqyxyj.2022.05.003

口腔医学研究 ›› 2022, Vol. 38 ›› Issue (5): 400-403.DOI: 10.13701/j.cnki.kqyxyj.2022.05.003

龈沟液内正畸牙移动相关生物标志物的研究进展

管佳妮^1,2,3, 严斌^1,2,3*

1.南京医科大学附属口腔医院正畸科江苏南京 210029;
2.江苏省口腔疾病研究重点实验室江苏南京 210029;
3.江苏省口腔转化医学工程研究中心江苏南京 210029

收稿日期:2021-11-04 出版日期:2022-05-28 发布日期:2022-05-20
通讯作者: *严斌,E-mail:byan@njmu.edu.cn
作者简介:管佳妮(1996~),女,江苏苏州人,硕士在读,研究方向:口腔正畸学。
基金资助:
国家自然科学基金(编号:82071143)

Advances in Biomarkers Related to Orthodontic Tooth Movement in Gingival Crevicular Fluid

GUAN Jiani^1,2,3, YAN Bin^1,2,3*

1. Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing 210029, China;
2. Jiangsu Province Key Laboratory of Oral Diseases, Nanjing 210029, China;
3. Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing 210029, China

Received:2021-11-04 Online:2022-05-28 Published:2022-05-20

摘要/Abstract

摘要： 龈沟液是存在于龈沟和牙周袋内的一种组织渗透液。对牙齿施加正畸力会引起牙周组织改建和龈沟液内生化介质水平的改变。分析正畸牙移动时龈沟液内特异性生物标志物水平的变化有助于医生了解患者牙周组织的改建状态并监测牙齿移动,从而可以为患者制定个性化的矫治方案、缩短治疗周期和避免不良反应。目前龈沟液内与正畸牙移动相关的生物标志物参与的生物学过程可被分为3大类:炎症、骨吸收与形成、组织损伤与修复。本文拟对具有潜在应用前景的龈沟液内正畸牙移动相关生物标志物作一综述。

关键词: 正畸, 牙齿移动, 龈沟液, 生物标志物, 牙周组织改建

Abstract: Gingival crevicular fluid is a kind of tissue permeation fluid in gingival sulcus and periodontal pocket. The application of orthodontic force to teeth will lead to remodeling of periodontal tissue and changes of biochemical mediators in gingival crevicular fluid. Analyzing the changes of specific biomarkers in gingival crevicular fluid during orthodontic tooth movement is helpful for doctors to understand the remodeling status of patients' periodontal tissue and monitor tooth movement, so as to develop personalized orthodontic treatment plan for patients, shorten the treatment period, and avoid adverse reactions. At present, the biological processes of biomarkers related to orthodontic tooth movement in gingival crevicular fluid can be divided into three categories: inflammation, bone resorption and formation, and tissue injury and repair. This article reviews the potential biomarkers related to orthodontic tooth movement in gingival crevicular fluid.

Key words: orthodontics, tooth movement, gingival crevicular fluid, biomarker, periodontium remodeling

管佳妮, 严斌. 龈沟液内正畸牙移动相关生物标志物的研究进展[J]. 口腔医学研究, 2022, 38(5): 400-403.

GUAN Jiani, YAN Bin. Advances in Biomarkers Related to Orthodontic Tooth Movement in Gingival Crevicular Fluid[J]. Journal of Oral Science Research, 2022, 38(5): 400-403.

参考文献

[1] de Aguiar MC, Perinetti G, Capelli JJ. The gingival crevicular fluid as a source of biomarkers to enhance efficiency of orthodontic and functional treatment of growing patients [J]. Biomed Res Int, 2017, 2017: 3257235.
[2] Zhang B, Yang L, Zheng W, et al. MicroRNA-34 expression in gingival crevicular fluid correlated with orthodontic tooth movement [J]. Angle Orthod, 2020, 90(5): 702-706.
[3] Marcantonio CC, Nogueira AVB, Leguizamon NDP, et al. Effects of obesity on periodontal tissue remodeling during orthodontic movement [J]. Am J Orthod Dentofacial Orthop, 2021, 159(4): 480-490.
[4] Afacan B, Öztürk VÖ, Geçgelen Cesur M, et al. Effect of orthodontic force magnitude on cytokine networks in gingival crevicular fluid: a longitudinal randomized split-mouth study [J]. Eur J Orthod, 2019, 41(2): 214-222.
[5] Alikhani M, Chou MY, Khoo E, et al. Age-dependent biologic response to orthodontic forces [J]. Am J Orthod Dentofacial Orthop, 2018, 153(5):632-644.
[6] Coates BA, McKenzie JA, Yoneda S, et al. Interleukin-6 (IL-6) deficiency enhances intramembranous osteogenesis following stress fracture in mice [J]. Bone, 2021, 143: 115737.
[7] An Z, Li J, Yu J, et al. Neutrophil extracellular traps induced by IL-8 aggravate atherosclerosis via activation NF-κB signaling in macrophages [J]. Cell Cycle, 2019, 18(21): 2928-2938.
[8] Kapoor P, Kharbanda OP, Monga N, et al. Effect of orthodontic forces on cytokine and receptor levels in gingival crevicular fluid: a systematic review [J]. Prog Orthod, 2014, 15(1):65.
[9] Garlet TP, Coelho U, Silva JS, et al. Cytokine expression pattern in compression and tension sides of the periodontal ligament during orthodontic tooth movement in humans [J]. Eur J Oral Sci, 2007, 115(5): 355-362.
[10] Noguchi T, Kitaura H, Ogawa S, et al. TNF-α stimulates the expression of RANK during orthodontic tooth movement [J]. Arch Oral Biol, 2020, 117: 104796.
[11] Padisar P, Hashemi R, Naseh M, et al. Assessment of tumor necrosis factor alpha (TNFα) and interleukin 6 level in gingival crevicular fluid during orthodontic tooth movement: a randomized split-mouth clinical trial [J]. Electron Physician, 2018, 10(8): 7146-7154.
[12] Lisowska B, Kosson D, Domaracka K. Lights and shadows of NSAIDs in bone healing: the role of prostaglandins in bone metabolism [J]. Drug Des Devel Ther, 2018, 12: 1753-1758.
[13] Dudic A, Kiliaridis S, Mombelli A, et al. Composition changes in gingival crevicular fluid during orthodontic tooth movement: comparisons between tension and compression sides [J]. Eur J Oral Sci, 2006, 114(5): 416-422.
[14] Topal SÇ, Tuncer BB, Elgun S, et al. Levels of cytokines in gingival crevicular fluid during rapid maxillary expansion and the subsequent retention period [J]. J Clin Pediatr Dent, 2019, 43(2):137-143.
[15] Kaur A, Kharbanda OP, Rajeswari MR, et al. Levels of TGF-beta1 in peri-miniscrew implant crevicular fluid [J]. J Oral Biol Craniofac Res, 2020, 10(2): 93-98.
[16] Castroflorio T, Gamerro EF, Caviglia GP, et al. Biochemical markers of bone metabolism during early orthodontic tooth movement with aligners [J]. Angle Orthod, 2017, 87(1): 74-81.
[17] Yamaguchi M, Fukasawa S. Is inflammation a friend or foe for orthodontic treatment?: Inflammation in orthodontically induced inflammatory root resorption and accelerating tooth movement [J]. Int J Mol Sci, 2021, 22(5) :2388.
[18] Ono T, Hayashi M, Sasaki F, et al. RANKL biology: bone metabolism, the immune system, and beyond [J]. Inflamm Regen, 2020, 40(1): 2.
[19] Farahani M, Safavi SM, Dianat O, et al. Acid and alkaline phosphatase levels in GCF during orthodontic tooth movement [J]. J Dent (Shiraz), 2015, 16(3 Suppl): 237-245.
[20] Kapoor P, Monga N, Kharbanda OP, et al. Effect of orthodontic forces on levels of enzymes in gingival crevicular fluid (GCF): A systematic review [J]. Dental Press J Orthod, 2019, 24(2): 40.e1-40.e22.
[21] Marahleh A, Kitaura H, Ohori F, et al. TNF-alpha directly enhances osteocyte RANKL expression and promotes osteoclast formation [J]. Front Immunol, 2019, 10: 2925.
[22] Kaku M, Motokawa M, Tohma Y, et al. VEGF and M-CSF levels in periodontal tissue during tooth movement [J]. Biomed Res, 2008, 29(4): 181-187.
[23] Zhou Y, He X, Zhang D. Study of bone remodeling in corticotomy-assisted orthodontic tooth movement in rats [J]. J Cell Biochem, 2019, 120(9): 15952-15962.
[24] Chiba FY, Sumida DH, Moimaz SAS, et al. Periodontal condition, changes in salivary biochemical parameters, and oral health-related quality of life in patients with anorexia and bulimia nervosa [J]. J Periodontol, 2019, 90(12): 1423-1430.
[25] Tzannetou S, Efstratiadis S, Nicolay O, et al. Comparison of levels of inflammatory mediators IL-1beta and betaG in gingival crevicular fluid from molars, premolars, and incisors during rapid palatal expansion [J]. Am J Orthod Dentofacial Orthop, 2008, 133(5): 699-707.
[26] Sugiyama Y, Yamaguchi M, Kanekawa M, et al. The level of cathepsin B in gingival crevicular fluid during human orthodontic tooth movement [J]. Eur J Orthod, 2003, 25(1): 71-76.
[27] Rhee SH, Kang J, Nahm DS. Cystatins and cathepsin B during orthodontic tooth movement [J]. Am J Orthod Dentofacial Orthop, 2009, 135(1): 99-105.
[28] Romano F, Del Buono W, Bianco L, et al. Gingival crevicular fluid cytokines in moderate and deep sites of stage Ⅲ periodontitis patients in different rates of clinical progression [J]. Biomedicines, 2020, 8(11) : 515.
[29] Cevik-Aras H, Isik-Altun F, Kilic-Tok H, et al. Monitoring salivary levels of interleukin 1 beta (IL-1β) and vascular endothelial growth factor (VEGF) for two years of orthodontic treatment: A prospective pilot study [J]. Mediators Inflamm, 2021, 2021: 9967311.

龈沟液内正畸牙移动相关生物标志物的研究进展

Advances in Biomarkers Related to Orthodontic Tooth Movement in Gingival Crevicular Fluid

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

[1]	李爽, 胡敏. 关于正畸固定矫治中牙釉质脱矿的研究进展[J]. 口腔医学研究, 2021, 37(8): 685-688.
[2]	丁弘, 王伟, 徐宏, 修霞, 姜春苗. 不同下唇上缘曲线对前牙微笑弧美观性的影响研究[J]. 口腔医学研究, 2021, 37(8): 696-701.
[3]	刘冬晓, 夏连松, 黄川. 软组织移植用于治疗正畸后牙龈退缩的临床疗效分析[J]. 口腔医学研究, 2021, 37(8): 708-711.
[4]	全璐璐, 李雪微, 赵俊杰, 邓文振, 张旭, 董伟, 梁永强. 正畸改性流动树脂的体外研究[J]. 口腔医学研究, 2021, 37(8): 712-716.
[5]	胡敏, 贾一凡. 正畸治疗应如何规避颞下颌关节紊乱病的风险[J]. 口腔医学研究, 2021, 37(7): 583-587.
[6]	骆勤亮, 黄桂林. 唾液细胞外囊泡作为生物标志物诊断口腔疾病的研究进展[J]. 口腔医学研究, 2021, 37(5): 386-388.
[7]	郭飞扬, 花放. 正畸釉质脱矿微创治疗的研究进展[J]. 口腔医学研究, 2021, 37(4): 288-291.
[8]	周颖, 胡敏. 关于外科手术对骨性Ⅱ类错牙合畸形患者上气道及阻塞性睡眠呼吸暂停低通气综合征的影响[J]. 口腔医学研究, 2021, 37(12): 1073-1075.
[9]	张敏杰, 张苗苗, 季开心, 陈思言. 正畸力作用下压力侧牙周组织中RIP1、RIP3和MLKL的表达[J]. 口腔医学研究, 2021, 37(10): 906-909.
[10]	刘晓琳, 郑谦, 李承浩, 石冰, 杨超. PNAM治疗对单侧完全性唇裂术后效果的影响[J]. 口腔医学研究, 2021, 37(10): 919-923.
[11]	杨安迪, 毛慧敏, 雷浪. 成人双颌前突患者正畸前后上颌切牙区唇腭侧牙槽骨的变化[J]. 口腔医学研究, 2021, 37(1): 48-52.
[12]	段光远, 马超. 具有层纹的隐形正畸矫治器制作方法研究[J]. 口腔医学研究, 2020, 36(8): 723-725.
[13]	杨凯成, 杨蕾, 赵建广, 罗风玉, 陈彦平, 崔子峰, 陈赫, 满莎莎. 口腔鳞状细胞癌患者外周血microRNA的表达及预后意义[J]. 口腔医学研究, 2020, 36(5): 428-432.
[14]	任亚敏, 王亚楠, 陈劲宏, 郭人铭, 刘晗哲, 崔淑霞. 正畸对根管治疗牙牙根吸收的影响因素研究[J]. 口腔医学研究, 2020, 36(5): 459-461.
[15]	高睿, 闫伟军, 安晶涛, 宋冰, 邵玶. miR-146a激动剂对正畸复发过程牙周组织中炎症因子和IRAK1、TRAK6表达的影响[J]. 口腔医学研究, 2020, 36(5): 469-472.