唾液细胞外囊泡作为生物标志物诊断口腔疾病的研究进展

doi:10.13701/j.cnki.kqyxyj.2021.05.002

口腔医学研究 ›› 2021, Vol. 37 ›› Issue (5): 386-388.DOI: 10.13701/j.cnki.kqyxyj.2021.05.002

唾液细胞外囊泡作为生物标志物诊断口腔疾病的研究进展

骆勤亮¹, 黄桂林^1,2*

1.遵义医科大学贵州遵义 563000;
2.遵义医科大学附属口腔医院口腔颌面外科贵州遵义 563000

收稿日期:2020-03-13 发布日期:2021-05-17
通讯作者: * 黄桂林,E-mail:chaojiehuanghgl@163.com
作者简介:骆勤亮(1994~ ),男,贵州人,硕士在读,研究方向:唾液腺相关疾病。
基金资助:
国家自然科学基金地区科学基金项目(编号:8196030881)

Research Progress of Saliva Extracellular Vesicles as Biological Markers in Diagnosis of Oral Diseases

LUO Qinliang¹, HUANG Guilin^1,2*

1. Zunyi Medical University, Zunyi 563000, Guizhou;
2. Department of Oral and Maxillofacial Surgery, Stomatological Hospital Affiliated to Zunyi Medical University, Zunyi 563000, Guizhou

Received:2020-03-13 Published:2021-05-17

摘要/Abstract

摘要： 唾液与血液相似,含有大量生物学信息,是进行非侵入性诊断的理想体液。细胞外囊泡(EVs)是存在于大多数体液(包括唾液)内的一组细胞来源的纳米级异质囊泡,主要包括外泌体和微囊泡。细胞外囊泡是真核细胞和原核细胞共有的细胞间信号传递的媒介,可以将信号传递至受体细胞,从而介导细胞间通讯和信号传导;同时它在各种生物学功能中起着重要作用,包括蛋白质、核酸和脂质等生物活性分子的转移以及各种疾病的生理和病理过程的调节。由于这些特性,细胞外囊泡被认为是诊断和预测各种疾病极有价值的生物标志物。本文就唾液细胞外囊泡作为生物标志物诊断口腔疾病的研究进展作一综述。

关键词: 唾液, 细胞外囊泡, 生物标志物, 口腔疾病, 诊断

Abstract: Saliva is similar to blood and contains a large amount of biological information, which is the ideal body fluid for non-invasive diagnosis. Extracellular vesicles (EVs) are a group of cell-derived nanoscale heterogeneous vesicles existing in most body fluids (including saliva), mainly including exosomes and microvesicles. Extracellular vesicles are the common medium of inter-cell signal transmission between eukaryotic cells and prokaryotic cells, which can transmit signals to receptor cells, thus mediating inter-cell communication and signal transmission. At the same time, it plays an important role in various biological functions, including the transfer of biological active molecules such as proteins, nucleic acids and lipids, and the regulation of physiological and pathological processes of various diseases. Due to these characteristics, extracellular vesicles are considered to be valuable biological markers for diagnosis and prediction of various diseases. This article reviews the research progress of saliva extracellular vesicles as biological markers in the diagnosis of oral diseases

Key words: saliva, extracellular vesicles, biological markers, oral diseases, diagnosis

骆勤亮, 黄桂林. 唾液细胞外囊泡作为生物标志物诊断口腔疾病的研究进展[J]. 口腔医学研究, 2021, 37(5): 386-388.

LUO Qinliang, HUANG Guilin. Research Progress of Saliva Extracellular Vesicles as Biological Markers in Diagnosis of Oral Diseases[J]. Journal of Oral Science Research, 2021, 37(5): 386-388.

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唾液细胞外囊泡作为生物标志物诊断口腔疾病的研究进展

Research Progress of Saliva Extracellular Vesicles as Biological Markers in Diagnosis of Oral Diseases

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