口腔医学研究

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (10): 925-929.DOI: 10.13701/j.cnki.kqyxyj.2020.10.009

• 口腔肿瘤学研究 • 上一篇    下一篇

软组织多形性玻璃样变血管扩张性肿瘤的临床病理学分析

孙雅静*, 李宝江   

  1. 天津市第五中心医院病理科 天津 300450
  • 收稿日期:2020-02-15 出版日期:2020-10-28 发布日期:2020-10-19
  • 通讯作者: *孙雅静,E-mail:sunyajing2008@163.com
  • 作者简介:孙雅静(1981~ )女,天津人,主治医师,硕士,研究方向:病理学。

Clinicopathological Analysis of Pleomorphic Hyalinizing Angiectatic Tumor of Soft Tissue

SUN Yajing*, LI Baojiang   

  1. Department of Pathology, Tianjin Fifth Central Hospital, Tianjin 300450, China
  • Received:2020-02-15 Online:2020-10-28 Published:2020-10-19

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摘要： 目的: 探讨软组织多形性玻璃样变血管扩张性肿瘤(PHAT)的临床病理学特征、诊断及鉴别诊断。方法: 对我院收治软组织多形性玻璃样变血管扩张性肿瘤患者的临床和病理学资料进行回顾性分析并复习国内外相关文献。结果: 该例肿瘤呈结节状生长,与周围组织界限较清楚,包膜完整;镜下特征性组织学表现为较多薄壁扩张的血管,管壁见纤维素性物质沉积,并可见腔内血栓;血管间为多形性的核深染的瘤细胞,核分裂象罕见。免疫组化标记示CD34和Vimentin阳性,BCL-2和 CD99部分阳性,EMA、S-100、Desmin、SMA、Bcl-6阴性,Ki-67(约+3%)。AB黏液染色阳性。结论: 软组织多形性玻璃样变血管扩张性肿瘤是少见的软组织肿瘤,预后较好,免疫组化标记可协助诊断。

关键词: 软组织多形性玻璃样变血管扩张性肿瘤, 诊断, 鉴别

Abstract: Objective: To investigate the clinicopathological features, diagnosis, and differential diagnosis of pleomorphic hyalinized angiectatic tumor of soft tissue. Methods: Pleomorphic hyalinized angiectatic tumors of soft tissue were analyzed and reviewed. Results: Tumors were nodular, which had clear boundaries with the surrounding tissue. Tumors' diolame was complete or incomplete. Under the microscope, thin-walled dilated vascular wall were seen, which had fibrinous substance deposition and thrombus. Between vessels pleomorphic tumor cells were seen. The mitotic figure was rare. Immunohistochemical staining showed CD34(+), Vimentin(+), BCL-2 (Partial+),and Ki-67 (+3%). Conclusion: Pleomorphic hyalinized angiectatic tumor of soft tissue is a rare tumor which has good prognosis. However, it needs to be identified with multiple tumors. Immunohistochemical markers may assist the diagnosis.

Key words: pleomorphic hyalinized angiectatic tumor of soft tissue, diagnosis, differential