CYP27B1在口腔鳞状细胞癌中的表达及其与预后的关系

doi:10.13701/j.cnki.kqyxyj.2020.10.010

口腔医学研究 ›› 2020, Vol. 36 ›› Issue (10): 930-933.DOI: 10.13701/j.cnki.kqyxyj.2020.10.010

CYP27B1在口腔鳞状细胞癌中的表达及其与预后的关系

郭俊峰, 张纲, 谭颖徽^*

陆军军医大学(第三军医大学)第二附属医院口腔科重庆 400037

收稿日期:2020-04-08 出版日期:2020-10-28 发布日期:2020-10-19
通讯作者: *谭颖徽,E-mail:tanyhxqkq@163.com
作者简介:郭俊峰(1990~ ),男,重庆人,博士在读,主要从事口腔颌面外科研究。
基金资助:
重庆市教委创新领军人才“重庆英才计划”(2019)

Expression of CYP27B1 in Oral Squamous Cell Carcinoma and Its Relationship with Prognosis

GUO Junfeng, ZHANG Gang, TAN Yinghui^*

Department of Stomatology, Second Affiliated Hospital of Army Military Medical University (Third Military Medical University), Chongqing 400037, China

Received:2020-04-08 Online:2020-10-28 Published:2020-10-19

摘要/Abstract

摘要： 目的: 探讨CYP27B1在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)中的表达及其与预后的关系。方法: 在TCGA(The Cancer Genome Atlas)数据库中下载372例OSCC患者数据作为TCGA数据库研究队列,使用edgR算法计算OSCC患者的癌组织和癌旁组织中CYP27B1表达的差异,并进行分析;在新桥医院(陆军军医大学第二附属医院)口腔科选取146例OSCC患者作为新桥医院研究队列,将OSCC患者的癌组织和癌旁组织的临床石蜡组织切片进行免疫组织化学染色,检测CYP27B1的表达,按照CYP27B1表达结果的中位值将OSCC患者分为CYP27B1高表达组和CYP27B1低表达组,并结合患者临床资料分析CYP27B1表达与预后的关系。结果: TCGA数据库队列与新桥医院队列中CYP27B1在OSCC组织中呈低表达,Kaplan-Meier生存分析显示CYP27B1高表达组总体生存时间(overall survival,OS)显著高于低表达组,且具有统计学差异(P<0.05)。结论: CYP27B1在OSCC患者癌组织中低表达,可能与OSCC的发生、发展相关,并影响预后。

关键词: 口腔鳞状细胞癌, CYP27B1, 预后

Abstract: Objective: To investigate the expression of CYP27B1 in oral squamous cell carcinoma (OSCC) and its correlation with prognosis. Methods: The data of 372 patients with OSCC were downloaded from the TCGA (the cancer genome atlas) database as a TCGA database cohort to extract the CYP27B1 gene expression-related data of the above-mentioned patients. The differences of CYP27B1 expression in cancer and adjacent tissues of OSCC patients were calculated and analyzed using the edgR package. 146 patients with OSCC in the Department of Stomatology, Xinqiao Hospital (Second Affiliated Hospital of Army Military Medical University) were selected as a Xinqiao Hospital cohort. The paraffin sections of the patients were immunohistochemical stained, and the expression of CYP27B1 was detected. According to the CYP27B1 expression results, the median value of OSCC patients was divided into CYP27B1 high expression and CYP27B1 low expression group. Combined with the clinical medical records, the relationship between CYP27B1 expression and prognosis was analyzed. Results: CYP27B1 was expressed in OSCC tissues both in TCGA database cohort and Xinqiao Hospital cohort. Kaplan-meier survival analysis showed that the overall survival time (OS) of the group with high expression of CYP27B1 was significantly higher than that of the group with low expression (P<0.05). Conclusion: CYP27B1 poor expression may relate to the occurrence, development, and prognosis of OSCC.

Key words: oral squamous cell carcinoma, CYP27B1, prognosis

郭俊峰, 张纲, 谭颖徽. CYP27B1在口腔鳞状细胞癌中的表达及其与预后的关系[J]. 口腔医学研究, 2020, 36(10): 930-933.

GUO Junfeng, ZHANG Gang, TAN Yinghui. Expression of CYP27B1 in Oral Squamous Cell Carcinoma and Its Relationship with Prognosis[J]. Journal of Oral Science Research, 2020, 36(10): 930-933.

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CYP27B1在口腔鳞状细胞癌中的表达及其与预后的关系

Expression of CYP27B1 in Oral Squamous Cell Carcinoma and Its Relationship with Prognosis

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