氯己定在口腔细菌中敏感性下降及其相关机制的研究进展

doi:10.13701/j.cnki.kqyxyj.2024.08.002

摘要/Abstract

摘要： 氯己定(chlorhexidine, CHX)被广泛应用于医疗领域的表面消毒,然而其应用缺乏临床限制。其长期广泛应用已导致多种重要的院内感染病原体临床分离菌株出现CHX敏感性下降,并可产生对一系列关键抗生素的交叉耐药。然而,CHX已在口腔领域作为金标准应用超过50年,其在口腔细菌中的耐药风险却未被重视。因此,本文旨在回顾CHX在口腔细菌中敏感性下降的研究进展并对其相关机制进行阐述,引发口腔领域对于CHX应用潜在风险的关注。

关键词: 氯己定, 口腔细菌, 敏感性下降, 主动外排蛋白

Abstract: Chlorhexidine (CHX) is the most widely applicated biocide for clinical surface disinfection, however, there is a lack of regulations on its usage. The long-term and extensive utilization of CHX has led to the reduced susceptibility against CHX and cross-resistance towards an array of critical antibiotics in clinical isolates of multiple essential pathogens related to nosocomial infections. However, the potential resistance risk in oral bacteria has been overlooked even though CHX has been applied as the gold standard in dentistry for over 50 years. Hence, the current review aims to summarize the evidence of the reduced susceptibility to CHX in oral bacteria and elucidate the relative mechanisms to raise the concern about its potential risk in dental practice.

Key words: chlorhexidine, oral bacteria, reduced susceptibility, efflux pump

任静宜, 周文娟. 氯己定在口腔细菌中敏感性下降及其相关机制的研究进展[J]. 口腔医学研究, 2024, 40(8): 670-675.

REN Jingyi, ZHOU Wenjuan. An Update on Research Progress of Chlorhexidine Reduced Susceptibility in Oral Bacteria and Relative Mechanisms[J]. Journal of Oral Science Research, 2024, 40(8): 670-675.

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