口腔医学研究

口腔医学研究 ›› 2026, Vol. 42 ›› Issue (5): 421-425.DOI: 10.13701/j.cnki.kqyxyj.2026.05.010

• 牙周病学研究 • 上一篇    下一篇

含甘草酸二钾护龈牙膏抑制牙菌斑和减轻牙龈炎症的临床研究

李立芬1, 邬凤娟1, 刘继涛1*, 张依娜2, 宋康3, 高峰2*   

  1. 1.广州星际悦动股份有限公司研发部 广东 广州 510610;
    2.陕西中医药大学 陕西 咸阳 712046;
    3.陕西中医药大学第二附属医院口腔科 陕西 咸阳 712046
  • 收稿日期:2025-08-19 发布日期:2026-05-25
  • 通讯作者: *刘继涛,E-mail:liujt@starspulse.com
    高峰,E-mail:7204612@qq.com
  • 作者简介:李立芬(1986~ ),女,湖南人,硕士,工程师,研究方向:口腔护理产品的应用研发与技术攻关。

Clinical Study on Inhibition of Dental Plaque and Reduction of Gingival Inflammation by Toothpaste Containing Dipotassium Glycyrrhetate

LI Lifen1, WU Fengjuan1, LIU Jitao1*, ZHANG Yina2, SONG Kang3, GAO Feng2*   

  1. 1. Guangzhou Stars Pulse Co.,Ltd., Guangzhou 510610, China;
    2. Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China;
    3. Department of Stomatology, Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China
  • Received:2025-08-19 Published:2026-05-25

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摘要： 目的:探讨含甘草酸二钾有效成分的试验牙膏抑制牙菌斑,减轻牙龈炎症的临床效果。方法:本试验采用随机、双盲、对照的临床试验方法,选择符合纳入标准和不符合排除标准的志愿者为受试对象,对受试者先进行龈上洁治,除去牙石。设置对照组和试验组,试验组使用试验牙膏,对照组使用不含甘草酸二钾成分的牙膏,分别在产品使用前、使用后1周对受试者进行Quigley-Hein菌斑指数检查,在使用产品前、使用后1周、2周、6周和12周对Loe-Silness牙龈指数和出血指数进行检查。结果:基线时,对照组与试验组相比,菌斑指数、牙龈指数、出血指数均无显著性差异(P＞0.05),使用产品1周后,试验组菌斑指数为1.51±0.46,对照组菌斑指数为1.77±0.45,二者比较有显著差异(P＜0.01);试验组使用产品1周、2周、6周、12周牙龈指数分别为:1.26±0.26、0.96±0.27、0.51±0.19和0.32±0.25,除第1周外,试验组牙龈指数与对照组在同一访视点比较均有显著差异(P＜0.01);试验组使用产品1周、2周、6周、12周出血指数分别为:1.08±0.19、0.96±0.17、0.31±0.16、0.18±0.25,除第1周外,其余相同访视点下试验组的出血指数与对照组比较均有显著差异(P＜0.01)。结论:含甘草酸二钾有效成分的试验牙膏有抑制牙菌斑和减轻牙龈炎症、改善牙龈出血的作用。

关键词: 甘草酸二钾, 牙膏, 牙菌斑, 牙龈炎

Abstract: Objective: To investigate the clinical effect of toothpaste containing dipotassium glycyrrhizinate on inhibiting dental plaque and reducing gingival inflammation. Methods: This study used a randomized, double-blind, controlled clinical trial method. Volunteers who met the inclusion criteria and did not meet the exclusion criteria were selected as subjects. The subjects were first subjected to supragingival scaling to remove calculus. The control group and the experimental group were set up. The experimental group used the experimental toothpaste, and the control group used the toothpaste without dipotassium glycyrrhizinate. The Quigley-Hein plaque index was examined before and 1 week after the use of the product, and the Loe-Silness gingival index and bleeding index were examined before and 1 week, 2 weeks, 6 weeks, and 12 weeks after the use of the product. Results: At baseline, there was no significant difference in plaque index, gingival index, and bleeding index between the control group and the experimental group (P>0.05). One week after the product was used, the plaque index of the experimental group was 1.51±0.46. The plaque index of the control group was 1.77±0.45, and there was a significant difference between the two groups (P<0.01). The gingival indexes of the experimental group at 1 week, 2 weeks, 6 weeks, and 12 weeks were 1.26±0.26, 0.96±0.27, 0.51±0.19, and 0.32±0.25, respectively. Except for the first week, the gingival index of the experimental group was significantly different from that of the control group at the same visit point (P<0.01). The bleeding indexes of the experimental group at 1 week, 2 weeks, 6 weeks, and 12 weeks were: 1.08±0.19, 0.96±0.17, 0.31±0.16, and 0.18±0.25, respectively. Except for the first week, the bleeding indexes of the experimental group were significantly different from those of the control group (P<0.01). Conclusion: The experimental toothpaste containing dipotassium glycyrrhizinate has the effect of inhibiting dental plaque, reducing gingival inflammation, and improving gingival bleeding.

Key words: dipotassium glycyrrhizinate, toothpaste, dental plaque, gingivitis