口腔医学研究

口腔医学研究 ›› 2026, Vol. 42 ›› Issue (8): 681-687.DOI: 10.13701/j.cnki.kqyxyj.2026.08.008

• 口腔种植学研究 • 上一篇    下一篇

构建PDMS-CHXG涂层愈合基台的临床应用效果

冯宇, 汪建伟, 夏荣*   

  1. 安徽医科大学第二附属医院口腔科 安徽 合肥 230601
  • 收稿日期:2025-11-06 出版日期:2026-08-28 发布日期:2026-08-17
  • 通讯作者: *夏荣,E-mail:xiarongqh@aliyun.com
  • 作者简介:冯宇(1999~ ),女,安徽六安人,硕士,住院医师,研究方向:口腔种植修复。
  • 基金资助:
    2022年安徽省卫生健康科研项目(编号:AHWJ2022b017)

Clinical Application Effect of PDMS-CHXG Coating on Healing Abutments

FENG Yu, WANG Jianwei, XIA Rong*   

  1. Department of Stomatology, Second Affiliated Hospital, Anhui Medical University, Hefei 230601, China
  • Received:2025-11-06 Online:2026-08-28 Published:2026-08-17

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摘要： 目的: 构建聚二甲基硅氧烷-葡萄糖酸氯己定(polydimethylsiloxane-chlorhexidine gluconate,PDMS-CHXG)抗菌涂层的愈合基台,通过高通量测序及碱性品红溶液染色,与常规愈合基台对比,分析种植体周龈沟液菌群多样性及菌斑表面积占比,评价其临床抗菌成效。方法: 20例符合条件的患者(40颗种植体,拟行二期手术),实验组用PDMS-CHXG抗菌涂层愈合基台,对照组用无处理基台,同期放置,负载后第3、7天复诊。用滤纸条采集两种基台周围龈沟液,采用高通量测序技术分析两者不同菌门相对丰度差值。第7天取下愈合基台,经1%碱性品红水溶液染色1 min后,计算两者菌斑面积差值。结果: 与对照组相比,第3天实验组愈合基台周围龈沟液中种植体周围常见菌群(包括厚壁菌门等5类菌门)的检出数量明显减少(P<0.05),第7天,实验组变形菌门、放线菌门数量减小(P<0.05),其他3种菌门无明显差异(P>0.05)。同时,实验组基台表面菌斑面积占比明显减少(P<0.05)。结论: 种植二期手术后,愈合基台表面构建PDMS-CHXG涂层,其氯己定缓释形成短期的抗菌微环境,能降低种植体周围炎相关致病菌的附着量,具有一定的抗菌效果。

关键词: 种植二期手术, 聚二甲基硅氧烷-葡萄糖酸氯己定涂层, 愈合基台, 莫氏锥度, 高通量测序

Abstract: Objective: To construct polydimethylsiloxane-chlorhexidine gluconate (PDMS-CHXG) antibacterial coating on healing abutment, compare it with conventional healing abutments through high-throughput sequencing and basic fuchsin solution staining, analyze the diversity of gingival crevicular fluid flora around implants and the proportion of plaque surface area, and evaluate its clinical antibacterial efficacy. Methods: Twenty eligible patients (40 implants scheduled for secondary surgery) were enrolled. The experimental group used PDMS-CHXG antibacterial coated healing abutments, while the control group used untreated abutments. Both types of abutments were placed simultaneously, and follow-up visits were conducted on the 3rd and 7th days after loading. Gingival crevicular fluid around the two types of abutments was collected with filter paper strips, and high-throughput sequencing technology was used to analyze the difference in relative abundance of different bacterial phyla between them. On the 7th day, the healing abutments were removed, stained with 1% basic fuchsin aqueous solution for 1 minute, and the difference in plaque area percentage between the two groups was calculated. Results: Compared with the control group, the detection quantity of common peri-implant microbiota (including five phyla such as Firmicutes) in the gingival crevicular fluid around the experimental group's healing abutments was significantly reduced on the 3rd day (P<0.05). On the 7th day, the quantities of Proteobacteria and Actinobacteria in the experimental group were decreased (P<0.05), while there were no significant differences in the other three phyla (P>0.05). Meanwhile, the proportion of plaque area on the surface of the experimental group's abutments was significantly reduced (P<0.05). Conclusion: After secondary implant surgery, constructing a PDMS-CHXG coating on the surface of the healing abutment can form a short-term antibacterial microenvironment through the sustained release of chlorhexidine, reduce the adhesion of peri-implantitis-related pathogenic bacteria, and exhibit a certain antibacterial effect.

Key words: secondary implant surgery, polydimethylsiloxane-chlorhexidine gluconate coating, healing abutment, Morse taper, high-throughput sequencing