骨质疏松症及相关治疗药物对正畸治疗影响的研究进展

doi:10.13701/j.cnki.kqyxyj.2022.10.002

摘要/Abstract

摘要： 随着骨质疏松症发病率逐年增高,正畸患者中患有骨质疏松症的比例也在增加,骨质疏松症患者正常骨代谢受到破坏,这也对以牙周组织改建为基础的正畸牙移动产生了影响;由于治疗骨质疏松症的药物对骨改建的影响,同时也会对骨改建活跃的牙槽骨有着不同的作用,如何在保证正畸治疗效率的同时重建牙槽骨的骨改建平衡,应该是未来研究的重点。

关键词: 骨质疏松症, 正畸牙移动, 骨改建, 药物治疗

Abstract: With the increase of osteoporosis year by year, the proportion of orthodontic patients suffering from osteoporosis is also increasing. The normal bone metabolism of osteoporosis patients is destroyed, which also influences the orthodontic tooth movement based on the reconstruction of periodontal tissue. Due to the drugs treating osteoporosis affect bone remodeling, they may affect the alveolar bone. How to rebuild the bone remodeling balance of alveolar bone while ensuring the efficiency of orthodontic treatment should be the focus of future research.

Key words: osteoporosis, orthodontic tooth movement, bone remodeling, drug therapy

刘新煜, 胡敏. 骨质疏松症及相关治疗药物对正畸治疗影响的研究进展[J]. 口腔医学研究, 2022, 38(10): 913-916.

LIU Xinyu, HU Min. Research Advances in Effects of Osteoporosis and Related Therapeutic Agents on Orthodontic Treatment[J]. Journal of Oral Science Research, 2022, 38(10): 913-916.

参考文献

[1] Compston JE, McClung MR, Leslie WD. Osteoporosis[J]. Lancet, 2019, 393(10169):364-376.
[2] 朱洁,李建红,袁婷婷,等.绝经期妇女牙周状况与骨质密度的相关性分析[J].北京大学学报(医学版),2019,51(6):1115-1118.
[3] Xu S, Zhang G, Guo JF, et al. Associations between osteoporosis and risk of periodontitis: A pooled analysis of observational studies[J]. Oral Dis, 2021, 27(2):357-369.
[4] 王晓婷,陈荣敬,房兵.甲状旁腺激素应用于成人正畸治疗的实验研究进展[J].中华老年口腔医学杂志,2019,17(2):113-117+127.
[5] Li H, Xiao Z, Quarles LD, et al. Osteoporosis: mechanism, molecular target and current status on drug development[J]. Curr Med Chem, 2021, 28(8):1489-1507.
[6] Mazur I, Dilbarkhanov B, Kuracha X, et al. Periodontal status and bone metabolism in women in reproductive and postmenopausal periods[J]. Horm Mol Biol Clin Investig, 2020, 41(3).
[7] Molez AM, do Nascimento EHL, Haiter Neto F, et al. Effect of resveratrol on the progression of experimental periodontitis in an ovariectomized rat model of osteoporosis: Morphometric, immune-enzymatic, and gene expression analysis[J]. J Periodontal Res, 2020, 55(6):840-849.
[8] Di Naro E, Loverro M, Converti I, et al. The effect of menopause hypoestrogenism on osteogenic differentiation of periodontal ligament cells (PDLC) and stem cells (PDLCs): A systematic review[J]. Healthcare (Basel), 2021, 9(5):572.
[9] Só BB, Silveira FM, Llantada GS, et al. Effects of osteoporosis on alveolar bone repair after tooth extraction: A systematic review of preclinical studies[J]. Arch Oral Biol, 2021, 125:105054.
[10] Arioka M, Zhang X, Li Z, et al. Osteoporotic changes in the periodontium impair alveolar bone healing[J]. J Dent Res, 2019, 98(4):450-458.
[11] 朱洁,李建红,袁婷婷,等.绝经期女性骨质疏松与牙周重度附着丧失的相关性研究[J].中华口腔医学杂志,2020,55(3):159-164.
[12] Mohammed AO, Kaklamanos EG. Effect of ovariectomy-induced osteoporosis on the amount of orthodontic tooth movement: a systematic review of animal studies[J]. Eur J Orthod, 2021, 43(6):672-681.
[13] Minamoto C, Miyazawa K, Tabuchi M, et al. Alteration of tooth movement by reveromycin A in osteoprotegerin-deficient mice[J]. Am J Orthod Dentofacial Orthop, 2020, 157(5):680-689.
[14] Huang L, Yin X, Chen J, et al. Lithium chloride promotes osteogenesis and suppresses apoptosis during orthodontic tooth movement in osteoporotic model via regulating autophagy[J]. Bioact Mater, 2021, 6(10):3074-3084.
[15] Li T, Zhou Z, Wang H, et al. Effects of estrogen on root repair after orthodontically induced root resorption in ovariectomized rats[J]. Am J Orthod Dentofacial Orthop, 2020, 158(2):247-263.e1.
[16] Amaro ERS, Ortiz FR, Dorneles LS, et al. Estrogen protects dental roots from orthodontic-induced inflammatory resorption[J]. Arch Oral Biol, 2020, 117:104820.
[17] Deng L, Guo Y. Estrogen effects on orthodontic tooth movement and orthodontically-induced root resorption[J]. Arch Oral Biol, 2020, 118:104840.
[18] Omar M, Kaklamanos EG. Does the rate of orthodontic tooth movement change during pregnancy and lactation? A systematic review of the evidence from animal studies[J]. BMC Oral Health, 2020, 20(1):237.
[19] Noh JY, Yang Y, Jung H. Molecular mechanisms and emerging therapeutics for osteoporosis[J]. Int J Mol Sci, 2020, 21(20):7623.
[20] Di Vito A, Chiarella E, Baudi F, et al. Dose-dependent effects of zoledronic acid on human periodontal ligament stem cells: An in vitro pilot study[J]. Cell Transplant, 2020, 29:963689720948497.
[21] Li T, Yan Z, He S, et al. Intermittent parathyroid hormone improves orthodontic retention via insulin-like growth factor-1[J]. Oral Dis, 2021, 27(2):290-300.
[22] Li T, Wang H, Lv C, et al. Intermittent parathyroid hormone promotes cementogenesis via ephrinB2-EPHB4 forward signaling[J]. J Cell Physiol, 2021, 236(3):2070-2086.
[23] Azami N, Chen PJ, Mehta S, et al. Raloxifene administration enhances retention in an orthodontic relapse model[J]. Eur J Orthod, 2020, 42(4):371-377.
[24] Florencio-Silva R, Sasso GRS, Sasso-Cerri E, et al. Effects of estrogen status in osteocyte autophagy and its relation to osteocyte viability in alveolar process of ovariectomized rats[J]. Biomed Pharmacother, 2018, 98:406-415.
[25] Ou Q, Wang X, Wang Y, et al. Oestrogen retains human periodontal ligament stem cells stemness in long-term culture[J]. Cell Prolif, 2018, 51(2):e12396.
[26] Zymperdikas VF, Yavropoulou MP, Kaklamanos EG, et al. Effects of systematic bisphosphonate use in patients under orthodontic treatment: a systematic review[J]. Eur J Orthod, 2020, 42(1):60-71.
[27] Wu D, Meng B, Cheng Y, et al. The effect of risedronate on orthodontic tooth movement in ovariectomized rats[J]. Arch Oral Biol, 2019, 105:59-64.
[28] Li Y, Chen XY, Tang ZL, et al. Differences in accelerated tooth movement promoted by recombinant human parathyroid hormone after mandibular ramus osteotomy[J]. Am J Orthod Dentofacial Orthop, 2019, 155(5):670-680.
[29] Lu W, Li X, Yang Y, et al. PTH/PTHrP in controlled release hydrogel enhances orthodontic tooth movement by regulating periodontal bone remodaling[J]. J Periodontal Res, 2021, 56(5):885-896.
[30] de Oliveira D, de Oliveira Puttini I, Silva Gomes-Ferreira PH, et al. Effect of intermittent teriparatide (PTH 1-34) on the alveolar healing process in orchiectomized rats[J]. Clin Oral Investig, 2019, 23(5):2313-2322.
[31] 胡紫菱,朱光勋.中草药在口腔正畸及牙周炎症治疗中的研究进展[J].临床口腔医学杂志,2019,35(1):51-54.
[32] Zhu Z, Xie W, Li Y, et al. Effect of naringin treatment on postmenopausal osteoporosis in ovariectomized rats: A meta-analysis and systematic review[J]. Evid Based Complement Alternat Med, 2021, 2021:6016874.
[33] Wang W, Mao J, Chen Y, et al. Naringin promotes osteogenesis and ameliorates osteoporosis development by targeting JAK2/STAT3 signaling[J]. Clin Exp Pharmacol Physiol, 2022, 49(1):113-121.
[34] Wang L, Cheng L, Zhang B, et al. Tanshinone prevents alveolar bone loss in ovariectomized osteoporosis rats by up-regulating phosphoglycerate dehydrogenase[J]. Toxicol Appl Pharmacol, 2019, 376:9-16.
[35] Li Y, Hu W, Han G, et al. Involvement of bone morphogenetic protein-related pathways in the effect of aucubin on the promotion of osteoblast differentiation in MG63 cells[J]. Chem Biol Interact, 2018, 283:51-58.