口腔医学研究

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (3): 266-268.DOI: 10.13701/j.cnki.kqyxyj.2017.03.008

• 基础研究论著 • 上一篇    下一篇

正畸牙移动对大鼠血清及局部牙周组织雌激素水平影响的研究

沈兰花，孟玲娜，张瑞*   

  1. 黑龙江省医院南岗院区口腔科 黑龙江 哈尔滨 150001
  • 收稿日期:2016-07-10 出版日期:2017-03-20 发布日期:2017-03-22

Effect of Orthodontic Tooth Movement on Estrogen Levels in Serum and Local Periodontal Tissues of Rats.

SHEN Lan-hua, MENG Ling-na, ZHANG Rui*.   

  1. Department of Stomatology, Nangang Branch of Heilongjiang Provincial Hospital, Harbin 150001, China
  • Received:2016-07-10 Online:2017-03-20 Published:2017-03-22

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摘要： 目的:研究正畸牙移动对大鼠血清及局部牙周组织雌激素水平的影响。方法:选取105只wistar雌性大鼠,建立正畸牙移动实验模型,按照处理方式的不同,随机分为A(假处理组)、B(加力实验组)、C(空白对照组)3组,每组各35只,各组同时分为动情前期、动情期、动情后期、动情间期4个亚组,采用放射免疫法对大鼠血清雌激素水平进行测定,采用免疫组织化学法对大鼠局部牙周组织雌激素水平进行测定。结果:大鼠动情前期及动情期血清及局部牙周组织雌激素水平与动情后期及动情间期相比,均具有统计学差异(P<0.05);正畸牙移动可促使动情前期、动情期、动情后期、动情间期4个阶段中大鼠的血清及局部牙周组织雌激素水平显著增加(P<0.05)。结论:正畸牙移动促使血清雌激素水平增加,与全身应激反应有关;促使局部牙周组织雌激素水平增加,与局部应力作用下的牙周改建有关。

关键词: 雌激素, 正畸牙移动, 动情周期

Abstract: Objective: To study the effect of orthodontic tooth movement on the level of estrogen in serum and local periodontal tissues in rats. Methods: One hundred and five female wistar rats were selected for the orthodontic tooth movement model and randomly divided into A (sham group), B (afterburner experiment group) and C (control group) group. Each group was also divided into four subgroups of proestrus, estrus, metestrus, and diestrus. Rat serum and local dental periodontal tissue estrogen levels were measured by radioimmunoassay and immunohistochemical methods, respectively. Results: Compared with the rats in proestrus and estrus periods, estrogen levels in serum and local periodontal tissue of rats in the late diestrus showed differences with statistical significance (P<0.05). In addition, from proestrus to estrus, metestrus, and then diestrus period, orthodontic tooth movement led to remarkable increase of estrogen levels in serum and local dental periodontal tissue (P<0.05). Conclusion: The increase of estrogen levels caused by orthodontic tooth movement can be attributed to the systemic stress response. The increased estrogen levels in local periodontal tissue resulted from periodontal reconstruction by local stress.

Key words: Estrogen, Orthodontic tooth movements, Estrous cycle

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