口腔鳞状细胞癌组织中Periostin的表达及其在上皮间质转化中的作用

doi:10.13701/j.cnki.kqyxyj.2017.03.007

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (3): 262-265.DOI: 10.13701/j.cnki.kqyxyj.2017.03.007

口腔鳞状细胞癌组织中Periostin的表达及其在上皮间质转化中的作用

张杨安，关为群^*，李群，欧阳奇明

福建医科大学附属协和医院口腔科福建福州 350001

收稿日期:2016-08-30 出版日期:2017-03-20 发布日期:2017-03-22

Expression of Periostin in Oral Squamous Cell Carcinoma and Its Role in Epithehial-mesenchymal Transition.

ZHANG Yang-an, GUAN Wei-qun^*, LI Qun, OU YANG Qi-ming

Department of Stomatology, Fujian Medical University Union Hospital, Fuzhou 350001, China

Received:2016-08-30 Online:2017-03-20 Published:2017-03-22

摘要/Abstract

摘要： 目的:观察Periostin在口腔鳞状细胞癌组织中的表达情况,及其在上皮间质转化(EMT)中的作用。方法:用免疫组化法检测59例口腔鳞状细胞癌组织(实验组)和15例正常口腔黏膜组织(对照组)中Periostin、E-cadherin、Vimentin表达情况,分析Periostin与E-cadherin、Vimentin间相关关系。结果:59例口腔鳞状细胞癌组织中Periostin、E-cadherin、Vimentin阳性表达率分别为71.2%、52.5%、39.0%, Periostin表达与肿瘤TNM分期、分化程度、淋巴结转移密切相关(P＜0.05);且Periostin与E-cadherin表达降低和Vimentin表达上调间均存在相关性(P＜0.01)。结论:Periostin可能通过调控上皮间质转化促进口腔鳞状细胞癌侵袭转移。

关键词: Periostin, 口腔鳞状细胞癌, 上皮间质转化, 侵袭, 转移

Abstract: Objective: To investigate the expression of Periostin in oral squamous cell carcinoma (OSCC) and explore its role in epithehial-mesenchymal transition (EMT). Methods: Immunohistochemistry was used to detect the expression of Periostin, E-cadherin and Vimentin in 59 cases of oral squamous cell carcinoma specimens and 15 cases of normal oral mucosa specimens. The relationship between Periostin expression and EMT was also analyzed. Results: The positive rate of Periostin, E-cadherin and Vimentin in the specimens of OSCC patients was 71.2%, 52.5% and 39.0%, respectively. And the expression of Periostin was significantly correlated with TNM stage, tumor differentiation degree and lymph node metastasis (P＜0.05). Also, Periostin expression was negatively correlated with E-cadherin expression and positively correlated with Vimentin expression (P＜0.01). Conclusion: Periostin may promote the invasion and metastasis of oral squamous cell carcinoma through regulating epithehial-mesenchymal transition.

Key words: Periostin , Oral squamous cell carcinoma, Epithehial-mesenchymal transition , Invasion , Metastasis

中图分类号:

R739.8

张杨安，关为群，李群，欧阳奇明. 口腔鳞状细胞癌组织中Periostin的表达及其在上皮间质转化中的作用[J]. 口腔医学研究, 2017, 33(3): 262-265.

ZHANG Yang-an, GUAN Wei-qun, LI Qun, OU YANG Qi-ming. Expression of Periostin in Oral Squamous Cell Carcinoma and Its Role in Epithehial-mesenchymal Transition.[J]. Journal of Oral Science Research, 2017, 33(3): 262-265.

参考文献

[1] 韩影,苏彤,林璐,等.口腔癌对侧颈淋巴结转移的临床研究[J].口腔医学研究,2016,32(2)∶154-157
[2] Planche A, Bacac M, Provero P, et al. Identification of prognostic molecular features in the reactive stroma of human breast and prostate cancer [J]. PloS One,2011,6(5)∶e-18640
[3] Hong L, Sun H, Lv X, et al. Expression of periostin in the serum of NSCLC and its function on proliferation and migration of human lung adenocarcinoma cell line (A549) in vitro [J]. Mol Biol Rep,2010,37(5)∶2285-2293
[4] Guarino M. Epithelial-mesenchymal transition and tumour invasion [J]. Int J Biochem Cell Biol,2007,39(12)∶2153-2160
[5] Krisanaprakornkit S, Iamaroon A. Epithelial-mesenchymal transition in oral squamous cell carcinoma [J]. ISRN O- ncol,2012,20(12)∶681469
[6] Zhou J, Tao D, Xu Q, et al. Expression of E-cadherin and vimentin in oral squamous cell carcinoma [J]. Int J Clin Exp Pathol,2015,8(3)∶3150-3154
[7] 陈震,郭燕.E-cadherin和Vimentin在OSCC上皮-间质转化中的作用及表达[J].口腔医学研究,2016,32(8)∶857-860
[8] Weng W, Yin J, Zhang Y, et al. Metastasis-associated protein 1 promotes tumor invasion by downregulation of E-cadherin [J]. Int J Oncol,2014,44(3)∶812-818
[9] Banyard J, Bielenberg DR, et al. The role of EMT and MET in cancer dissemination [J]. Connect Tissue Res,2015,56(5)∶403-13
[10] Oskarsson T, Acharyya S, Zhang XH, et al. Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs [J]. Nat Med,2011,17(7)∶867-874
[11] Chiodoni C, Colombo MP, Sangaletti S. Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis [J]. Cancer Metastasis Rev, 2010, 29(2)∶295-307
[12] Ratajczak-Wielgomas K, Dzegiel P. The role of periostin in neoplastic processes [J]. Folia Histochem Cytobiol,2015,53(2)∶120-132
[13] Morra L, Rechsteiner M, Casagrande S, et al. Relevance of periostin splice variants in renal cell carcinoma [J]. The American journal of pathology,2011,179(3)∶1513-1521

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口腔鳞状细胞癌组织中Periostin的表达及其在上皮间质转化中的作用

Expression of Periostin in Oral Squamous Cell Carcinoma and Its Role in Epithehial-mesenchymal Transition.

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