破骨细胞在慢性根尖周炎中作用的研究进展

doi:10.13701/j.cnki.kqyxyj.2025.05.001

摘要/Abstract

摘要： 慢性根尖周炎往往伴随着牙槽骨的吸收,破骨细胞的分化与增长在慢性根尖周炎的发生发展中发挥着重要作用。研究表明,多种相关因子及酶能够促进或抑制破骨细胞的分化,影响慢性根尖周炎的发展。近年来,慢性根尖周炎中的破骨细胞在不同因子作用下的不同反应,及其所展现的未来治疗方向逐渐引起了学界关注。在临床治疗中,人为干预相关通路,如抑制核因子-κB(nuclear factor-κB, NF-κB)途径的激活、激活磷酸肌醇3-激酶(phosphatidylinositide 3-kinase, PI3K)信号通路,也具有一定的治疗潜力。但相关治疗措施仍需进一步临床研究,其临床有效性亦有待评估。本文旨在对目前破骨细胞在慢性根尖周炎中作用的研究进展及可能的治疗方案进行综述。

关键词: 慢性根尖周炎, 口腔疾病, 破骨细胞, 骨吸收

Abstract: Chronic apical periodontitis is frequently characterized by alveolar bone resorption, with osteoclast differentiation and proliferation playing pivotal roles in its development. Research indicates that various factors and enzymes associated with chronic apical periodontitis can either promote or inhibit osteoclast function which influenced the response of osteocytes in the affected areas. Moreover, scholarly attention is increasingly focusing on the treatment of chronic apical periodontitis. Strategies targeting relevant pathways, such as inhibiting NF-κB activation or activating the PI3K signaling pathway, are considered promising. Nevertheless, these therapeutic interventions require further clinical investigation, and their efficacy in clinical settings warrants evaluation. This article aims to provide a comprehensive review of current advancements concerning the role of osteoclasts and potential treatment modalities for chronic apical periodontitis.

Key words: chronic apical periodontitis, oral disease, osteoclasts, bone resorption

卫晓萱, 李博磊. 破骨细胞在慢性根尖周炎中作用的研究进展[J]. 口腔医学研究, 2025, 41(5): 363-368.

WEI Xiaoxuan, LI Bolei. Research Progress on Roles of Osteoclasts in Chronic Apical Periodontitis[J]. Journal of Oral Science Research, 2025, 41(5): 363-368.

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