口腔医学研究

口腔医学研究 ›› 2016, Vol. 32 ›› Issue (4): 388-390.DOI: 10.13701/j.cnki.kqyxyj.2016.04.017

• 临床研究论著 • 上一篇    下一篇

种植牙术后全身与局部用药对PCT、CRP的影响及治疗效果研究

王怡丹*,欧洪波,李婷燕,李帮辉,何吉琼   

  1. 遵义市第一人民医院口腔科,遵义医学院第三附属医院口腔科 贵州 遵义 563002
  • 收稿日期:2016-02-14 出版日期:2016-04-28 发布日期:2016-04-28
  • 通讯作者: 王怡丹,E-mail: wydlyc@163.com
  • 作者简介:王怡丹(1971~ ),女,陕西富平人,硕士,副主任医师,研究方向为免疫防龋和口腔种植修复。
  • 基金资助:
    省市科技合作专项资金项目(编号:省市科合[2014]41)

Effects of Systemic and Topical Medication on PCT and CRP after Dental Implantation Surgery.

WANG Yi-dan*, OU Hong-bo, LI Ting-yan, LI Bang-hui, HE Ji-qiong.   

  1. The First People’s Hosptial of Zunyi, Zunyi 563002, China
  • Received:2016-02-14 Online:2016-04-28 Published:2016-04-28

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摘要： 目的:探讨口腔种植牙术后全身与局部抗感染对降钙素原(PCT)、C-反应蛋白(CRP)的影响及治疗效果,为临床研究提供参考依据。方法:选择2014年1月~2015年11月120例行口腔种植牙的患者作为研究对象,采用随机数字表法分为全身组与局部组各60例,在常规治疗基础上全身组给予奥硝唑治疗,局部组在制备好的种植窝洞内及切口部位给予盐酸米诺环素治疗。于治疗前及治疗后3 d抽取静脉血检测PCT、CRP水平,并比较两组术后疼痛及疗效差异。结果:局部组总有效率95.0%明显高于全身组83.3%,差异有统计学意义(P<0.05)。局部组疼痛发生率41.7%比例明显低于全身组60.0%,差异有统计学意义(P<0.05)。结论:口腔种植牙行局部抗感染治疗疗效及止痛效果明显好于全身治疗患者。

关键词: 口腔种植牙, 降钙素原, C-反应蛋白, 奥硝唑

Abstract: Objective: To compare the effects of systemic and topical medication on PCT and CRP after oral dental implantation surgery. Methods: Totally 120 patients with dentition defect, who undenwent the dental implantation surgery from January 2014 to November 2015, were included and randomly divided into the systemic medication group and the topical medication group. Patients in systemic group were given ornidazole treatment, while patients in local group were given minocycline treatment around the implant or inside the incision. The levels of PCT and CRP before and after treatment and the postoperative pain and curative effects were compared. Results: The total effective rate in local group was 95.0%, which was significantly higher than 83.3% of general group (P<0.05). When compared the incidence of postoperative pain, the topical group (41.7%) was significantly superior to the general group (60.0%). Conclusion: The topical administration of minocycline hydrochloride is superior to the systemic administration on the prevention of infection after the dental implantation surgery.

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