大鼠舌黏膜癌变过程中E-cad、CD44s的表达

doi:10.13701/j.cnki.kqyxyj.2017.02.010

口腔医学研究 ›› 2017, Vol. 33 ›› Issue (2): 158-161.DOI: 10.13701/j.cnki.kqyxyj.2017.02.010

大鼠舌黏膜癌变过程中E-cad、CD44s的表达

刘琼瑶, 廖鹏程, 谭红, 张绪, 王敏, 聂敏海^*

西南医科大学附属口腔医院口颌面修复重建和再生实验室四川泸州 646000

收稿日期:2016-06-14 出版日期:2017-02-20 发布日期:2017-02-22
通讯作者: 聂敏海,E-mail:nieminhai@126.com
作者简介:刘琼瑶(1988~ ),女,硕士在读,主要研究方向:口腔黏膜病的病因及防治研究。
基金资助:
四川省科技厅(编号:2014LY-62)

Expression of E-cad and CD44s in the Rat Tongue Carcinogensis.

LIU Qiong-yao, LIAO Peng-cheng, TAN Hong, ZHANG Xu, WANG Min, NIE Min-hai^*

Stomatology Hospital and Lab of Orofacia Reconstruction and Regeneration, Southwest Medical University, Luzhou 646000, China

Received:2016-06-14 Online:2017-02-20 Published:2017-02-22

摘要/Abstract

摘要： 目的:探索蛋白E-cad、CD44s在大鼠舌黏膜癌变过程中的表达变化。方法:屏障环境下4NQO饮水法诱导SD大鼠舌黏膜癌变,采用免疫组化法检测82例大鼠舌黏膜标本组织中E-cad、CD44s的表达情况。结果:在大鼠舌黏膜癌变过程中,E-cad表达下降、CD44s表达上升,E-cad、CD44s的表达差异有统计学意义(P<0.05)。相关性分析表明E-cad与CD44s表达呈负相关,相关性有统计学意义(r_s=-0.675,P<0.001)。结论:E-cad和CD44s在舌鳞癌的发生、发展中起了一定的作用, 联合检测E-cad和CD44s的表达可能为临床早期诊断提供新的方法。

关键词: 舌鳞状细胞癌, 免疫组化, E-cad, CD44s

Abstract: Objective: To explore the expression of E-cad and CD44s in the rat tongue carcinogensis. Methods: The water drinking method of 4NQO was used in a barrier system to induce tongue carcinogensis of SD rats. Immunohistochemical technique was used to study the expression of E-cad and CD44s in 82 tissue specimens of rat tongue carcinogensis. Results: In the process of rat tongue carcinogensis, the expression of E-cad decreased while that of CD44s increased, and the differences in the expression of E-cad and CD44s were statistically significant for each group (P<0.05). The expression of E-cad had a significantly negative correlation with CD44s expression (r_s=-0.675, P<0.001). Conclusion: E-cad and CD44s were involved in the occurrence and development of tongue squamous cell carcinoma, and combined detection of CD44s and E-cad may provide a new method for early clinical diagnosis.

Key words: Tongue squamous cell carcinoma, E-cad , CD44s

中图分类号:

R739.8

刘琼瑶, 廖鹏程, 谭红, 张绪, 王敏, 聂敏海. 大鼠舌黏膜癌变过程中E-cad、CD44s的表达[J]. 口腔医学研究, 2017, 33(2): 158-161.

LIU Qiong-yao, LIAO Peng-cheng, TAN Hong, ZHANG Xu, WANG Min, NIE Min-hai. Expression of E-cad and CD44s in the Rat Tongue Carcinogensis.[J]. Journal of Oral Science Research, 2017, 33(2): 158-161.

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大鼠舌黏膜癌变过程中E-cad、CD44s的表达

Expression of E-cad and CD44s in the Rat Tongue Carcinogensis.

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