Journal of Oral Science Research ›› 2018, Vol. 34 ›› Issue (11): 1244-1248.DOI: 10.13701/j.cnki.kqyxyj.2018.11.023

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TLR4-MyD88 Signal Pathway in Trigeminal Ganglia Involved in Immunoreactivity Induced by Temporomandibular Joint Inflammation in Rats

LI Wei-jia1,2,LI Lu-jia1, FAN Fan1, JIN Hai-wei1*   

  1. 1. School of Stomatology, Dalian Medical University, Dalian 116044, China;
    2.Department of Oral Medicine, HulunBuir People's Hospital,Hulunbeier 021008,China.
  • Received:2018-06-15 Online:2018-11-28 Published:2018-11-23

Abstract: Objective: To investigate the dynamic expression of TLR4 and its signal pathway in trigeminal ganglia (TG) by using a temporomandibular joint inflammation (TMJI) animal model in rats, and further to explore the role of TLR4 signal pathway involved in the neural immune response during process of TMJI and accompanied pain. Methods: Rats model of TMJI were established by intra-articular injection of Freund's adjuvant complete. Histopathological examination showed the progressive pathological changes in the TMJ were detected by HE staining, and the expression of TLR4 or MyD88 in TG were observed by immunohistochemistry. Results: The expression of TLR4 and MyD88 in TG increased significantly post TMJI. Correlation analysis showed low correlation between TLR4 and MyD88 expression. Conclusion: TLR4-MyD88 signal pathway in TG involved in neural immune response during TMJI. The signal transduction of activation of TLR4 in neurons may be mediated by MyD88 dependent pathway.

Key words: Temporomandibular joint inflammation, TLR4, MyD88, Neural immune response