Impact of Oral Appliance Treatment for Moderate Mandibular Advancement on Obstructive Sleep Apnea Syndrome and Upper Airway Volume

doi:10.13701/j.cnki.kqyxyj.2021.03.011

Abstract

Abstract: Objective: To investigate the impact of moderate mandibular advancement device (MAD) on obstructive sleep apnea syndrome (OSAS) and upper airway volume. Methods: 57 OSAS patients underwent oral appliance therapy with MAD in Henan Province Hospital of TCM from June 2017 to September 2018 were enrolled. Indicators of symptoms and signs were compared between baseline and 6 months after treatment. Nasal resistance, airway volume, and in situ cross-sectional area were recorded. Based on apnea hypopnea index (AHI) reduction, the treatment response was classified as complete, partial, and non-complete. The influencing factors of treatment outcomes 6 months after MAD therapy, and upper pharyngeal airway patency and nasal resistance with and without MAD in situ were analyzed. Furthermore, multivariate analysis was carried out on the predictors. Data were processed by SPSS20.0 software. Results: The average age of male was smaller than that of female. The proportions of married and educational level above college degree were higher in male than in female (P<0.05). Age and post-treatment AHI of complete response group were lower than those of partial/non-complete response group (P<0.05). While the AHIsupine and overbite were higher than those of partial/non-complete response group (P<0.05). The AHI, AHIsupine, and oxygen saturation (SaO₂) were lower than 90%. Snoring, snoring symptoms, sleep quality, and total nasal inspiratory resistance of data after 6 months therapy/MAD in situ were lower than those of data without MAD in situ (P<0.05). The nasopharynx volume, oropharynx volume, hypopharynx volume, minimum cross-sectional area, and total pharyngeal airway volume were higher than those of data without MAD in situ (P<0.05). Convex profile had a positive correlation. Increased lower facial height and laryngopharyngeal reflux were negatively correlated with the increase in total upper airway volume (P<0.05), and there was no significant correlation with other indicators (P>0.05). Conclusion: Excellent MAD therapy outcomes are achieved in most patients. After treatment, the increase in airway volume is positively correlated with convex profile, and negatively associated with increased lower facial height and laryngopharyngeal reflux.

Key words: oral appliance therapy with moderate mandibular advancement, obstructive sleep apnea syndrome, upper airway volume

SUN Bohui, SUN Zhichao, DONG Xiaochen, WANG Mengmeng, SUN Maiqing. Impact of Oral Appliance Treatment for Moderate Mandibular Advancement on Obstructive Sleep Apnea Syndrome and Upper Airway Volume[J]. Journal of Oral Science Research, 2021, 37(3): 232-236.

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