Efficacy of Naproxen Sodium Combined with Codeine Phosphate on Pain and Edema following Extraction of Mandibular Impacted Wisdom Tooth

doi:10.13701/j.cnki.kqyxyj.2021.03.013

Journal of Oral Science Research ›› 2021, Vol. 37 ›› Issue (3): 242-245.DOI: 10.13701/j.cnki.kqyxyj.2021.03.013

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Efficacy of Naproxen Sodium Combined with Codeine Phosphate on Pain and Edema following Extraction of Mandibular Impacted Wisdom Tooth

XIE Hongliang^*, TANG Jianming, LU Lu, LI Bohan, WANG Mengmeng

Department of Oral and Maxillofacial Surgery, Stomatological Medical Center, Shenzhen People's Hospital, The First Affiliated Hospital of South University of Science and Technology, The Second Clinical Medical College of Ji’Nan University, Shenzhen 518020, China

Received:2020-09-21 Published:2021-03-19

Abstract

Abstract: Objective: To compare the clinical efficacies of naproxen sodium combined with codeine phosphate, losoprofen, and ibuprofen in the treatment of pain and edema following mandibular impacted wisdom tooth extraction. Methods: 90 healthy volunteers who asked impacted wisdom tooth extraction were randomly distributed into three groups. 1 hour before and 2 to 7 days after tooth extraction, patients were administrated separatly with naproxen sodium+codeine phosphate tablet, losuprofen, or ibuprofen. The postoperative pain, edema, and trismus were recorded and analyzed. Results: Naproxen sodium combined with codeine phosphate was found to be more effective for pain, edema, and trismus compared to losuprofen and ibuprofen (P<0.05). Losuprofen yielded similar clinical responses to ibuprofen (P>0.05). Conclusion: Naproxen sodium combined with codeine phosphate can be used as a better choice for the treatment of pain, edema, and trismus after mandibular impacted wisdom tooth extraction.

Key words: naproxen sodium, codeine phosphate, impacted wisdom tooth, analgesia

XIE Hongliang, TANG Jianming, LU Lu, LI Bohan, WANG Mengmeng. Efficacy of Naproxen Sodium Combined with Codeine Phosphate on Pain and Edema following Extraction of Mandibular Impacted Wisdom Tooth[J]. Journal of Oral Science Research, 2021, 37(3): 242-245.

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Efficacy of Naproxen Sodium Combined with Codeine Phosphate on Pain and Edema following Extraction of Mandibular Impacted Wisdom Tooth

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