Research Progress on Root Canal Biofilm Models In Vitro

doi:10.13701/j.cnki.kqyxyj.2024.02.003

Abstract

Abstract: Bacterial biofilm is the main cause of pulpal/periapical diseases and endodontic treatment failures. The establishment of in vitro root canal biofilm models is an important part of root canal infection control studies. Whether the selection, design, and construction of the models are scientific and rigorous directly affects the results and significance of the studies. This paper reviews the endodontic biofilm models commonly used in latest in vitro studies, and discusses the various constitutive factors, such as the microbial composition, the selection and pre-treatment of substrates, and the inoculation and growth conditions, hoping to provide a reference for the selection and design of more scientific and sound models and the development of more stable and reproducible standardized models that can better mimic the in vivo conditions for future research.

Key words: root canal biofilm, experimental model, endodontic infection, root canal microbiome

BAO Pingping, DENG Jiayin. Research Progress on Root Canal Biofilm Models In Vitro[J]. Journal of Oral Science Research, 2024, 40(2): 108-112.

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