基因治疗骨关节病的研究进展

doi:10.13701/j.cnki.kqyxyj.2018.03.004

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (3): 229-232.DOI: 10.13701/j.cnki.kqyxyj.2018.03.004

基因治疗骨关节病的研究进展

崔诗曼, 张清彬^*

广州医科大学附属口腔医院·广州口腔疾病研究所·口腔医学重点实验室广东广州 510140

收稿日期:2016-06-27 出版日期:2018-03-30 发布日期:2018-03-27
通讯作者: *张清彬,E-mail:doctorqingbin@hotmail.com
作者简介:崔诗曼(1990~ ),女,河北人,硕士,主要从事口腔颌面外科颞下颌关节方向,口腔组织工程学研究。
基金资助:
广东省科学技术厅项目(编号:2016ZC0147);广州医科大学校级博士基金(编号:2015C43)

Research Progress of Gene Therapy on Osteoarthrosis.

CUI Shi-man, ZHANG Qing-bin^*

Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University. Guangzhou 510140, China

Received:2016-06-27 Online:2018-03-30 Published:2018-03-27

摘要/Abstract

摘要： 骨关节病是常见的以软骨损伤为特征的关节退行性疾病,目前的治疗方法较多,但大多实施困难且效果不佳。颞下颌关节骨关节病作为一种常见的口腔颌面疾病,其修复与治疗对临床和科研工作者具有挑战性。基因治疗是近年发展起来的一项新兴诊疗技术,因其对软骨生物学性能的潜在修复力而逐渐引起人们重视。它主要涉及到靶细胞、目的基因、载体这三方面的问题,本文就此作一综述。

关键词: 骨关节病, 基因治疗, 颞下颌关节

Abstract: Osteoarthrosis is a common degenerative joint disease, which is characterized by cartilage injury. Temporomandibular joint osteoarthrosis is a common oral and maxillofacial disease, its repair and treatment are quite challenging job to clinical and scientific researchers. It is a lot of treatment of this disease, but the effect is not satisfactory. Gene therapy is a new treatment technology developed in recent years, which involves the target cell, gene, carrier and so on. This article summarized the current literature on gene therapy of osteoarthrosis.

Key words: Osteoarthrosis, Gene therapy, Temporomandibular joint

崔诗曼, 张清彬. 基因治疗骨关节病的研究进展[J]. 口腔医学研究, 2018, 34(3): 229-232.

CUI Shi-man, ZHANG Qing-bin. Research Progress of Gene Therapy on Osteoarthrosis.[J]. Journal of Oral Science Research, 2018, 34(3): 229-232.

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基因治疗骨关节病的研究进展

Research Progress of Gene Therapy on Osteoarthrosis.

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