药物性牙龈增生发病机制的研究进展

doi:10.13701/j.cnki.kqyxyj.2018.04.003

口腔医学研究 ›› 2018, Vol. 34 ›› Issue (4): 350-352.DOI: 10.13701/j.cnki.kqyxyj.2018.04.003

药物性牙龈增生发病机制的研究进展

焦晓菊^1,2, 周佳¹, 徐烁¹, 吉秋霞^1*

1. 青岛大学附属医院口腔牙周病科山东青岛 266001;
2. 冀中能源邢台矿业集团有限责任公司总医院口腔科河北邢台 054000

收稿日期:2017-03-03 出版日期:2018-04-28 发布日期:2018-04-25
通讯作者: 吉秋霞,E-mail:jqx_1@163.com
作者简介:焦晓菊(1988~ )女,河北,医师,硕士,主要从事口腔牙周方向。
基金资助:
国家自然科学基金(编号: 81401526)山东省优秀中青年科学家奖励基金(编号:BS2010CL015)

Research Progress on Mechanisms of Drug-induced Gingival Overgrowth

JIAO Xiao-Ju^1,2, ZHOU Jia¹, XU Shuo¹, JI Qiu-xia^1*

1. Department of Periodontics, The Affiliated Hospital of Qingdao University, Qingdao 266001, China;
2. Department of Stomatology, The General Hospital of Xingtai Mining Industry Bloc, Jizhong Enery Group CO, LTD, Xingtai 054000, China.

Received:2017-03-03 Online:2018-04-28 Published:2018-04-25

摘要/Abstract

摘要： 药物性牙龈增生是指服用药物引起的牙龈增生和体积增大,具有共同的病理组织学特点,而其发病机制目前仍无定论。本综述主要从胶原合成降解、炎症和基因三方面对药物性牙龈增生的发病机制做一综述,对指导医疗专业人员有效防治药物性牙龈增生具有一定参考价值。

关键词: 药物性牙龈增生, 胶原, 硝苯地平, 苯妥英钠, 环孢素

Abstract: Drug-induced gingival overgrowth (DGO) is the gingival hyperplasia and volume enlargement, which is a side effect associated with 3 types of drugs: anticonvulsants, calcium channel blockers, and immunosuppressive agents. It is characterized by some common pathological features. However, the mechanisms and clinical treatment of these disorders have not been elucidated. This review provides an overview of the pathogenesis of drug-induced gingival hyperplasia from three aspects, i.e. collagen synthesis and degradation, inflammation, and genetics, with of great importance in guiding the medical professionals to effectively prevent drug-induced gingival hyperplasia.

Key words: Drug-induced, gingival hyperplasia, Collagen, Nifedipine, Phenytoin, Cyclosporine

焦晓菊, 周佳, 徐烁, 吉秋霞. 药物性牙龈增生发病机制的研究进展[J]. 口腔医学研究, 2018, 34(4): 350-352.

JIAO Xiao-Ju, ZHOU Jia, XU Shuo, JI Qiu-xia. Research Progress on Mechanisms of Drug-induced Gingival Overgrowth[J]. Journal of Oral Science Research, 2018, 34(4): 350-352.

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药物性牙龈增生发病机制的研究进展

Research Progress on Mechanisms of Drug-induced Gingival Overgrowth

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